Anbu Mozhi

Anbu Mozhi  

 

Personal Particulars
Research Fellow
NUS Environmental Research Institute

1 Create Way, CREATE Tower,

Singapore 138602

Office:Chemical & Biomolecular Engineering (WS2-06-17)
Phone: (65) 83506458
Email: eriamt@nus.edu.sg

Education

2012-2017:      Doctor of Philosophy (Ph.D.) in Nanoscience and Technology, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, P. R. China.

Title: Peptide Conjugated PEG-based Biodegradable Polymeric Nanomicelles for Cancer Drug Delivery.

2007-2010:      M.Sc., M.Tech. in Nanoscience and Nanotechnology, National Center for Nanoscience and Nanotechnology, University of Madras, Chennai, India.

2004-2007:      B.Sc. Advanced Zoology and Biotechnology, University of Madras, Chennai, India.

Research Interests

  • Synthesis and characterization of stimuli responsive biodegradable amphiphilic block copolymers
  • Construction of nanoparticle platforms for effective drug delivery/photodynamic therapy, imaging/diagnosis and nanomaterials-enabled immunotherapy for cancer
  • Design of polymer-drug conjugates for the eradication of bacterial infection
  • Nanocomposites for the inhibition of amyloid causing proteins

Technical Experience

  • Synthesis of block copolymers via ROP, ATRP, RAFT and Michael addition.
  • Synthesis of inorganic nanomaterial like Ceria nanosphere/nanocubes, Au, Fe, GO/Au, GO/IO, GO/IO/CS.
  • Synthesis of prodrug conjugates.
  • Preparation of microbial culture media, sterilization, Mass cultivation of bacteria for the determination of Minimum Inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC), Nanocomposites on Gram (+) and Gram (-) bacterial biofilm eradication.
  • Demonstrated experience in handling MRI imaging, biochemical tools and assays, such as flow cytometry, confocal microscopy, western blots, analysis of immune system stimulation, Immunohistochemistry staining, Cell processing for Bio-TEM imaging and histopathology studies.
  • Experience in cellular and cancer biology (2D and 3D multicellular spheroids) techniques.
  • Prior experience in working with animal model for burn wound treatment (Sprague Dawley Rats) and breast cancer/orthotopic glioblastoma Multiforme (Nude Mice).

Publications

  • Anbu Mozhi, Vishnu Sunil, Wenbo Zhan, Pramila Baban Ghode, Nitish V Thakor and Chi-Hwa Wang*, Enhanced Penetration of Pro-Apoptotic and Anti-Angiogenic Micellar Nanoprobe in 3D Multicellular Spheroids for Chemophototherapy. Journal of Controlled Release (2020), 323, 502-518. IF = 7.940
  • Jia Heng Teoh, Anbu Mozhi, Pooya Davoodi, Srinivas Ramasamy, Sanjairaj, Qiaoyun Yang, Teresa Dicolandrea, Helen Zhao, Jerry Fuh, Yih-Cherng Liou and Chi-Hwa Wang*, Investigation of the application of a taylor-couette bioreactor in the post-processing of bioprinted human dermal tissue, Biochemical Engineering Journal (2019), 151,107317. IF = 3.37
  • Anbu Mozhi, Israr Ahmad, Ruslan G Tuguntaev, Ahmad Shaker Eltahan, Shizhu Chen, Chan Li *, Xing-Jie Liang*, Nrp-1 receptor targeting peptide functionalized TPGS micellar nanosystem to deliver 10-hydroxycampotothecin for cancer chemotherapy. International Journal of Pharmaceutics 2018, 547, 582-592. IF = 4.320; Cited by 7
  • Anbu Mozhi, Israr Ahmad, Okeke C, Chan Li *, and Xing-Jie Liang*, pH-Sensitive Polymeric Micelles for codelivery of Proapoptotic Peptide and anticancer drug for synergistic cancer therapy. RSC Advance 2017, 7, 12886-12896. IF = 3.16; Cited by 19.
  • Israr Ahmad,Anbu Mozhi, Lin Yang, Qiusan Han, Xing-Jie Liang, Chan Li, Rong Yang*, and Chen Wang*, Graphene Oxide/Iron Oxide Nanocomposite as an Inhibitor of β-Amyloid. Colloids and Surfaces B: Biointerfaces 2017, 159, 540-545. IF = 4.040; Cited by 4 
  • Ruslan G. Tuguntaeva, Shizhu Chen, Ahmed Shaker Eltahan, Anbu Mozhi, Shubin Jin, Jinchao Zhang, Chan Li*, and Xing-Jie Liang*, P-gp Inhibition and Mitochondria impairment by Dual-functional Nanostructure Based on Vitamin E Derivatives to Overcome Multidrug Resistance. ACS Applied Materials and Interfaces 2017, 9, 16900-16912. IF = 8.330; Cited by 28.
  • Shizhu Chen, Keni Yang, Ruslan G Tuguntaev, Anbu Mozhi, Jinchao Zhang, Paul C Wang, Xing-Jie Liang*, Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome the chemoresistance. Nanomedicine 2016, 12, 269. IF = 5.620; Cited by 62.
  • Juan Liu, Yurang Huang, Anil Kumar, Aaorn Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang*, pH Sensitive nano-systems for drug delivery in cancer therapy. Biotechnology Advances 2014, 32, 693. IF = 13.220; Cited by 630.
  • Hongmei Liu, Yan li, Anbu Mozhi, Liang Zhang, Yilan Liu, Xia Xu, Jianmin Xing, Xing-Jie Liang*, Guanghui Ma, Jun Yang, Xin Zhang*, SiRNA Phospholipids conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 6519. IF = 10.250; Cited by 57
  • Anil Kumar, Fei Chen, Anbu Mozhi, Xu Zhang, Yuanyuan Zhao, Xiangdong Xue Yanli Hao, Xiaoning Zhang, Paul C Wang, Xing-Jie Liang*, Innovative pharmaceutical development based on unique properties delivery formulation. Nanoscale 2013, 5, 8307. IF = 6.97; Cited by 67

Patents

  • C.M. Babu, Zhiyi Y, T. Anbu Mozhi, C.H. Wang*, 2019, A Cost-effective way of converting low grade carbon to activated for environmental applications. ILO Ref: 2019-377
  • J.H. Teoh, T. Anbu Mozhi, Jerry Y.H. Fuh, S.M. Tay, C.H. Wang*, 2020, Photocrosslinkable, drug-loaded, customizable, on-demand hydrogel wound dressings for the treatment of thermal burns. ILO Ref: 2020-186
  • Xing-Jie Liang*, Anbu Mozhi, Chan Li, Israr Ahmad, Chukwunweike Ikechukwu Okeke, pH-sensitive and angiogenesis targeting polymeric micelles for co-delivery of proapoptotic peptide and docetaxel and their preparation. Patent number: 201710010597.1

Conferences/Invited Speaker

  1. Guest Speaker – Live Webinar conducted by CELLINK Life Science, “3D Bioprinting Pipeline of a Full Thickness Human Skin Model”, National University of Singapore, June 11, Singapore.
  2. Invited Speaker at the workshop NUS-Zhejiang University on “Glutathione modified Pro-Apoptotic and Anti-Angiogenic Micellar Nanoprobe for Chemophototherapy of High-grade Glioma”, National University of Singapore, (July 24-25, 2019), Singapore.
  3. Jia Heng Teoh, Anbu Mozhi and Chi-Hwa Wang, ‘Post-processing of 3D Bioprinted Human Dermal Tissues in the Dynamic Culture Environment of a Taylor-Couette Device’, Poster presentation in the 2019 AIChE Annual meeting, Orlando, USA.
  4. Vishnu Sunil, Anbu Mozhi and Chi-Hwa Wang, “Enhanced tumor delivery of SP1 Protein Inhibitor using DSPE-PEG Micelles for the treatment of recurrent high-grade glioma”. Poster presentation in the Controlled Release Society (CRS), (July 21-24, 2019), Valencia, Spain.
  5. He Li, B. C. Mohan, Anbu Mozhi, Chi-Hwa Wang, “Waste to Resource: Synthesis of electrolyte in vanadium redox flow battery from fly ash”, AIChE Annual Meeting, 10-15 November, 2019; Orlando, Florida, USA.
  6. H. Teoh, Anbu Mozhi, S.M. Tay, C.H. Wang, “Complex Multi-layered Microparticle Laden Fixed Hydrogel Wound Dressing Fabricated via 3D Printing for the Treatment of Thermal Burns”, AIChE Annual Meeting, 10-15 November, 2019; Orlando, Florida, USA.
  7. International Conference on Nanoscience & Technology, China Nano 2013 and 2015 Beijing, China.
  8. Molecular basis of diagnosis, prevention and treatment of infectious diseases, Institute of Biophysics, Chinese Academy of Sciences, October, 2013, Beijing, China
  9. Green Nanotechnology, Institute of Process Engineering, Chinese Academy of Sciences 2013, Beijing, China.

Awards and Achievements

  • President scholarship (2015-2017), National Center for Nanoscience & Technology, Chinese Academy of Sciences, Beijing, China.
  • Director Major Award 2014, National Center for Nanoscience & Technology, Chinese Academy of Sciences, Beijing, China.
  • Director Major Award 2013, National Center for Nanoscience & Technology, Chinese Academy of Sciences, Beijing, China.
  • Awarded Chinese Government Scholarship for International Student. (2012 – 2016).