Personal Particulars

Ph.D. Student

Education

B.Sc. (Biological Science), Peking University, China, 2007.

Research Interests

Development and evaluation of biodegradable controlled release devices for synergetic therapy of malignant brain tumors

Microfiber delivering RNAi plasmid for glioma therapy.

Fig. 1: Microfibers encapsulated with RNAi plasmid-PEI complex (shown by the arrows in the locally enlarged diagram).

Surface-coated nanoparticles for paclitaxel delivery through the blood-brain barrier.

Fig. 2: FESEM images of paclitaxel-loaded PLGA nanoparticles with various surface coatings.

Publications

J.Xie, C. Lei, Y. Hu, G.K. Gay, N. H. B. Jamali, C.H. Wang, “Nanoparticulate Formulations for Paclitaxel Delivery across MDCK Cell Monolayer “, Current Pharmaceutical Design, 16, 2331-2340 (2010).

P.C. Chang, L.P. Lim, L.Y. Chong, A..S.M. Dovban, L.Y. Chien, M.C. Chung, C Lei, C.H. Chen, H.C. Chiang, Y.P. Kuo, C.H. Wang, “PDGF-Simvastatin Delivery Stimulates Osteogenesis in Heat-induced Osteonecrosis”, Journal of Dental Research, 91(6) 618-624 (2012).

P.C. Chang, L.P. Lim, L.Y. Chong, A..S.M. Dovban, L.Y. Chien, M.C. Chung, C Lei, C.H. Chen, H.C. Chiang, Y.P. Kuo, C.H. Wang, “PDGF-Simvastatin Delivery Stimulates Osteogenesis in Heat-induced Osteonecrosis”, Journal of Dental Research, 91(6) 618-624 (2012).

C. Lei, Y. Cui , L. Zheng, P.K.H. Chow, C.H. Wang, “Development of a gene/drug dual delivery system for brain tumor therapy: Potent inhibition via RNA interference and synergistic effects”, Biomaterial, 34(30), 7483-7494 (2013).