SPHS introduction

The Singapore Population Health Studies (SPHS) is a population-based health research initiative of the Saw Swee Hock School of Public Health, National University of Singapore. The goals of SPHS are to discover how lifestyle factors, physiological factors, genetic factors and their interactions impact the development of common health conditions. In addition, we aim to monitor risk factors in the population and gain insight into determinants of health-related behaviours. For this purpose, SPHS involves the participation of 50,000 adult Singaporeans and long-term residents from three major ethnic groups (Chinese, Malay and Indian). SPHS will thus lead to a better understanding of health issues in urban Asian settings, and to the development of improved preventive and therapeutic measures for our local population as well as other Asian populations.

SPHS consists of several cohort studies: the Multi-ethnic Cohort (MEC)¹, the Diabetic Cohort (DC)¹, Singapore Health (SH) studies and the Community Health Study (CHS).

The MEC comprises large numbers of each ethnic group that do not have chronic diseases such as diabetes, cardiovascular disease and cancer at baseline. This allows the comparison of risk factors for such diseases across ethnic groups and the study of their relationship with chronic disease outcomes during follow-up of the cohort.

DC studies the determinants of complications among persons with type 2 diabetes. The participants were recruited from multiple primary and tertiary health care institutions. Medical records data are being gathered from both archived notes and the Electronic Medical Records Exchange shared by the public health care sector.

SH studies are nationally representative cross-sectional surveys with consent obtained from the participants to allow longitudinal follow-up.

CHS is conducted on selected neighbourhoods in Singapore to profile the health status and assess the health needs of the residents. Consent is also obtained from the participants for longitudinal follow-up.

These studies examined lifestyle factors such as diet, alcohol consumption, tobacco use and environmental tobacco exposure, physical activity, sleep habits and sedentary behaviours. These data were collected through face-to-face interviews using validated questionnaires. In addition, participants were all invited for health examinations that included measurement of body fatness and blood pressure, additional physiological parameters depending on the cohort and collection of blood and urine samples. Blood and urine samples were typically collected for immediate tests on blood glucose and lipids and urine protein levels and also stored for future research on cardio-metabolic risk factors and metabolomics profiles. Genome-wide association studies and sequencing have generated extensive genetic information from some of the cohorts and further laboratory investigations are being planned for the stored samples. Disease follow-up for all the cohorts is conducted by active follow-up every 5 years and linkage to national disease and death registries.

The links below will direct you to more detailed information about each cohort including a description of the study population, the collected data, and links to the consent and data collection forms and related references.

MEC
DC
SH
CHS

¹ MEC and DC were formerly cohorts of the Singapore Consortium of Cohort Studies, which later evolved into the present SPHS as its research mandate subsequently extended to other types of population-based studies.

DATA AND SAMPLES AVAILABLE FOR RESEARCH

Data Dictionary Whole blood DNA (*buffy coat) Plasma Citrate plasma Serum PBMC Red blood cells Clot Urine
Multiethnic Cohort (2006-2010) Download (0.3MB)
Multiethnic Cohort (2013-2015) Download (0.1MB) *√
Revisit of the Multiethnic Cohort Download (1.1MB) *√
Diabetic Cohort Download (0.2MB)
Revisit of the Diabetic Cohort Download (0.9MB) *√
Singapore Health 2012 Download (0.2MB)
Singapore Health 2 Download (1.2MB)
Community Health Study Download (0.1MB) *√

Requesting data and/or samples

To enquire about or request for data and/or samples, please refer to this protocol, complete the enclosed form and send it to sphs_data_request@nus.edu.sg.

PARTNERS

Biomedical Research Council
National Healthcare Group Polyclinics
NUH Referral Laboratory
NUH Tissue Repository
• Singapore Breast Cancer Cohort (a study group of the Breast Cancer Association Consortium)
SingHealth Polyclinics

INVESTIGATORS

From Saw Swee Hock School of Public Health:
Professor Chia Kee Seng
Associate Professor Rob Martinus van Dam
Associate Professor Tai E Shyong
Associate Professor Jeannette Lee Jen Mai
Professor Wong Tien Yin
Professor Saw Seang Mei
Assistant Professor Chen I-Cheng Mark
Associate Professor Teo Yik Ying
Assistant Professor Mueller-Riemenschneider Falk

Dr Lim Su Chi (Senior Consultant, Khoo Teck Phuat Hospital)
Dr Tang Wern Ee (Head, Clinical Research Unit, National Healthcare Group Polyclinics)
Dr Richard Chen (National Healthcare Group Polyclinics)
Dr Siew Wei Fong (National Healthcare Group Polyclinics)
Dr Seet Lin Tze (National Healthcare Group Polyclinics)
Dr Darren Seah Ee-Jin (National Healthcare Group Polyclinics)
Dr Tan Ngiap Chuan (Director, Research, Singhealth Polyclinics)
Dr Kon Yin Chian (Senior Consultant, Tan Tock Seng Hospital)
Dr Eric Khoo Yin Hao (Consultant, National University Hospital)
Dr Adeline Tan Yit Ying (Consultant, Alexandra Hospital)
Dr Ronald Lee Chi Hang (Consultant, National University Hospital)
Associate Professor Reshma Merchant (Yong Loo Lin School of Medicine, National University of Singapore)
Dr Lee Chun Tsu (Senior Resident, National University Hospital)

SPHS ADMINISTRATION

Saw Swee Hock School of Public Health
National University of Singapore
Tahir Foundation Building
12 Science Drive 2
#11-03
Singapore 117549

Linda Tan
Operations Manager
E: ephtanl@nus.edu.sg
T: +65 6601 4973

Josephine Lim
Health Screening Operations Manager
E: ephlpk@nus.edu.sg

Last updated on 28 Oct 2016