| Year 2025
(as a corresponding PI*) 271. Cell-Active Irreversible Covalent Inhibitors that Chemoselectively Target Drug-Resistant TRKAG595R and ALKG1202R Kinase Mutants xxxx (2025), in preparation. Zuqun Wang, Xuan Wang, Jiahuan He, Lu Wang, Yan Zhang, Xiaojuan Song, Fang Yang, Shenjie Huang, Yang Zhou, Zhengchao Tu, Liqian Gao, Zhang Zhang,* Zhi-Min Zhang,* Shao Q. Yao,* Xiaoyun Lu* 270. Comparative studies of catalytic lysine-targeting covalent strategies in the human kinome. xxxx. (2025), in preparation. Guanghui Tang,† Xuan Wang,† Fengfei Miao,† Huisi Huang, Manyi Xu, Chong-Jing Zhang, Liqian Gao, Zhi-Min Zhang,* Shao Q. Yao,* Xiaoyun Lu* 269. A Photonic Hydrogel Platform for Intelligent Point-of-care Identification of Cancers xxxx (2025), in preparation Junjie Qin, Xingxing Yang, Jia Guo, Chengrui Hu, Shao Q. Yao,* Chengxi Li* 268. Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals xxxx (2025), submitted Tao Li, Xiaotong Ze, Yiqing Wang, Wenjie zhang, Fengfei Miao, Peng Chen, Guanghui Tang, Jing Xiang, Guangyu Xu, Jiaqian Yan, Miaomiao Wang, Min Liu, Xiaojie Wang, Wei Tao, Fan Yi, Zhi-Min Zhang,* Rui Wang,* Shao Q Yao,* Yusheng Xie* 267. Cell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Non-Kinases and Kinases Angew. Chem. Int. Ed. (2025), in revision. Peng Chen, Lu Wang, Xuan Wang, Jie Sun, Fengfei Miao, Zuqin Wang, Fang Yang, Menghua Xiang, Mingxi Gu, Shengrong Li, Jianzhong Zhang, Peiyan Yuan, Xiaoyun Lu,* Zhi-Min Zhang,* Liqian Gao,* and Shao Q Yao,* 266. Chemical probe-enabled lipid droplet proteomics J. Am. Chem. Soc. (2025), in revision. Jing Xiang, Tao Li, Junzhe Zhang, Wenxian Wu, Guangyu Xu, Hao Wang, Suyuan Chen, Jiaqian Yan, Shao Q. Yao, Miaomiao Wang,* Fan Yi,* Jigang Wang,* Yusheng Xie* 265. PROTAC-Based Degradation of Catechol-O-Methyltransferase for Potential Treatment of Parkinson’s Disease Angew. Chem. Int. Ed. (2025), in revision. Haixiao Fang, Panpan Li, Shubo Du, Jing Gu, Xia Liu, Bo Peng, Cheng-wu Zhang, Hua Bai, Kai Huang, Lin Li,* Shao Q. Yao,* Wei Huang* 264. Tumor Microenvironment-Responsive Self-Assembled Nanomedicine for Reversible Covalent Targeting of BCR-ABL Kinase Chin. Chem. Lett. (2025), in press. Menghua Xiang, Fen Yang, Peng Chen, Jiaoyu Chen, Jianzhong Zhang, Jiayi Yang, Yilin Liu, Qianqian Zhang, Jiang Pi,* Peiyan Yuan,* Shao Q. Yao,* Liqian Gao,* Year 2024 263. A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2-Triggered Targeted Protein Degradation in Cancer Therapy J. Am. Chem. Soc. (2024), in press. Jie Sun, Mingxi Gu, Lvyang Peng, Jing Guo, Peng Chen, Yalei Wen, Fang Feng, Xiaojuan Chen, Tongzheng Liu, Yongheng Chen, Xiaoyun Lu,* Liqian Gao,* Shao Q Yao,* and Peiyan Yuan* 262. Rationally Designed BCR-ABL Kinase Inhibitors for Improved Leukemia Treatment via Covalent and Pro-/Dual-Drug Targeting Strategies J. Adv. Res. (2024), in press. Jie Sun, Liang Lou, Chengjun Zhu, Peng Chen, Guanghui Tang, Mingxi Gu, Shu Xia, Xiao Dong,* Zhi-Min Zhang,* Liqian Gao,* Shao Q. Yao,* Qicai Xiao* PDF (Suppl Info 1) (Suppl Info 2) 261. Small Molecule-Induced Posttranslational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells J. Am. Chem. Soc. (2024), 146, 23978–23988. Guanghui Tang,* Xuan Wang, Huisi Huang, Manyi Xu, Xingyu Ma, Fengfei Miao, Xiaoyun Lu, Chong-Jing Zhang, Liqian Gao, Zhi-Min Zhang,* Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) 260. Reactivity-Tunable Fluorescent Platform for Selective and Biocompatible Modification of Cysteine or Lysine Adv. Sci. (2024), 11, 2402838. Xiaojie Ren, Haokun Li, Hui Peng, Yang Yang, Hang Su, Chen Huang, Xuan Wang, Jie Zhang, Zhiyang Liu, Wenyu Wei, Ke Cheng, Zhenpin Lu, Zhengqiu Li, Qian Zhao, Benzhong Tang, Shao Q. Yao,* Xiangzhi Song,* and Hongyan Sun* PDF (Suppl Info 1) (Suppl Info 2) 259. Kinase Inhibition via Small Molecule-Induced Intramolecular Protein Cross-Linking Angew. Chem. Int. Ed. (2024), 63, e202404195 Xuan Wang, Jie Sun, Huisi Huang, Guanghui Tang, Peng Chen, Menghua Xiang, Lin Li, Zhi-Min Zhang,* Liqian Gao,* Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) 258. Prodrug-Conjugated Tumor-Seeking Commensals for Targeted Cancer Therapy Nat. Commun. (2024), 15, 4343. Haosheng Shen, Changyu Zhang, Kwok Soon Wun, Jing Liu, Saravanan Prabhu Nadarajan, Cheng Weng, Hua Ling, Joshua K Tay, De Yun Wang, Shao Q. Yao, In Young Hwang,* Yung Seng Lee, Matthew Wook Chang* 257. Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies Angew. Chem. Int. Ed. (2024), 63, e202319232. Jinning Shao, Xuefen Lin, Chuhan Zhao, Shao Q. Yao, Jingyan Ge, Su Zeng, Linghui Qian* 256. Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development Angew. Chem. Int. Ed. (2024), 63, e202316394 Guanghui Tang,* Wei Wang, Chengjun Zhu, Huisi Huang, Peng Chen, Xuan Wang, Manyi Xu, Jie Sun, Chong-Jing Zhang, Qicai Xiao, Liqian Gao, Zhi-Min Zhang,* and Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) Year 2023 255. Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy ACS Cent. Sci. (2023), 9, 1864-1893. Xiao Dong,* Shu Xia, Shubo Du, Mao-Hua Zhu, Xing Lai, Shao Q. Yao, Hong-Zhuan Chen, and Chao Fang* 254. Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently Chem. Commun. (2023), 59, 10789-10792. Wei Wang, Xuan Wang, Guanghui Tang,* Chengjun Zhu, Menghua Xiang, Qicai Xiao, Zhi-Min Zhang,* Liqian Gao* and Shao Q Yao* 253. Insulin-Like Growth Factor 2 (IGF2)-fused, Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins J. Am. Chem. Soc. (2023), 145, 24272-24283. Bei Zhang, Rajeev K. Brahma, Liquan Zhu, Jiayi Feng, Shiqi Hu, Linghui Qian, Shubo Du,* Shao Q. Yao,* Jingyan Ge* 252. Cell-Active, Irreversible Covalent Inhibitors that Selectively Target the Catalytic Lysine of EGFR by Using Fluorosulfate-Based SuFEx Chemistry Eur. J. Med. Chem. (2023), 259, 115671. Guanghui Tang, Wei Wang, Xuan Wang, Ke Ding, SoFong Cam Ngan, Jiaoyu Chen, Siu Kwan Sze, Liqian Gao, Peiyan Yuan,* Xiaoyun Lu,* Shao Q. Yao* 251. Orthogonal Strategies for the Global Proteome Profiling of Anandamide and Cannabidiol Chem. Eur. J. (2023), 29, e202300682. Guanghui Tang, Ying-Jie Lim,* Wei Wang, Zi Ye, Chong-Jing Zhang and Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) 250. A Late-Stage Aryl C-H Olefination Strategy and Its Application Towards Global Proteome Profiling of ∆8-Tetrahydrocannabinol Chem. Eur. J. (2023), 29, e202300531. Ying-Jie Lim, Guanghui Tang, Zi Ye, Chong-Jing Zhang, Jie Wu* and Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) 249. Mitochondria-Targeted Gene Silencing Facilitated by Mito-CPDs Chem. Eur. J. (2023), 29, e202204021. Wenjie Lang, Wei Tan, Bizhong Zhou, Yuli Zhuang, Bei Zhang, Linye Jiang, Shao Q. Yao,* Jingyan Ge* 248. The Dawn of a New Era: Targeting the ‘Undruggables’ with Antibody-Based Therapeutics Chem. Rev. (2023), 123, 7782-7853. Linghui Qian,* Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du,* Jingyan Ge, Su Zeng, Shao Q. Yao* 247. 2-Ethynylbenzaldehyde (EBA)-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Non-Kinases J. Am. Chem. Soc. (2023), 145, 3844-3849. Peng Chen, Guanghui Tang,* Chengjun Zhu, Jie Sun, Xuan Wang, Menghua Xiang, Huisi Huang, Wei Wang, Lin Li, Zhi-Min Zhang,* Liqian Gao,* Shao Q Yao* PDF (Suppl Info 1) (Suppl Info 2) 246. Multiplex Identification of Post-translational Modifications by Deep Learning-assisted Photonic Crystal Hydrogel Sensors Angew. Chem. Int. Ed. (2023), 62, e202218412. Junjie Qin, Jia Guo, Guanghui Tang, Lin Li, Shao Q. Yao* 245. De Novo Designed Self-assembling Rhodamine Probe for Real-time, Long-term and Quantitative Live-cell Nanoscopy ACS Nano (2023), 17, 3632-3644. Zhang, Jie; Shi, Heng; Huang, Chen; Mei, Le; Guo, Qiang; Cheng, Ke; Wu, Pingzhou; Su, Dan; Chen, Qingxin; Gan, Shenglong; Shi, Jiahai; Chen, Jianlin; Yao, Shao; Chen, Xian-Kai; Tang, Ben Zhong; He, Jufang; Sun, Hongyan* 244. GPX4 degradation through covalent inhibitor-based PROTACs Bioorg. Chem. (2023), 134, 106461. Liquan Zhu, Shiqi Hu, Xiaoqiao Yan, Qian Zeng, Bei Zhang, Linye Jiang, Shao Q. Yao,* Jingyan Ge* 243. Biodegradable Silica Nanocapsules Enable Efficient Nuclear-Targeted Delivery of Native Proteins for Cancer Therapy Biomaterials (2023), 294, 122000. Wei Du, Shubo Du, Xiao Dong, Hua Bai, Jiamin Jiang, Shiping Hao, Fen Yang, Qicai Xiao, Bei Zhang, Jingyan Ge, Liqian Gao, Lin Li,* Shao Q. Yao,* Wei Huang* Year 2022 242. Bifunctional lipid-derived affinity-based probes (AfBPs) for analysis of lipid-protein interactome Acc. Chem. Res. (2022), 55, 3663-3674. Jingyan Ge, Shubo Du,* Shao Q. Yao* 241. Chemical Biology Tools for of Protein Lysine Acylation Angew. Chem. Int. Ed. (2022), 61, e202200303 Yusheng Xie, Shubo Du, Zhiyang Liu, Min Liu, Zhiqiang Xu, Xiaojie Wang, Jia Xuan Kee, Fan Yi*, Hongyan Sun* and Shao Q. Yao* 240. Cell-active, reversible and irreversible covalent inhibitors that selectively target the catalytic lysine of BCR-ABL kinase Angew. Chem. Int. Ed. (2022), 61, e202203878. Peng Chen, Jie Sun, Chengjun Zhu, Guanghui Tang*, Wei Wang, Manyi Xu, Menghua Xiang, Chong-Jing Zhang, Zhi-Min Zhang*, Liqian Gao*, Shao Q. Yao* PDF (Suppl Info 1) (Suppl Info 2) 239. In Vivo Targeted Delivery of Antibodies into Cancer Cells with pH-Responsive Cell-Penetrating Poly(disulfide) Chem. Commun. (2022), 58, 1314-1317. Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q. Yao, Su Zeng,* Linghui Qian* 238. Two-photon small-molecule fluorogenic probes for visualizing endogenous nitroreductase activities from tumor tissues of a cancer patient Adv. Healthc. Mater. (2022), 11, 2200400. Changmin Yu, Shuangxi Wang, Chenchen Xu, Yang Ding, Gaobing Zhang, Qicai Xiao, Limin Wang, Bin Fang, Chibin Pu, Jingyan Ge, Liqian Gao, Naidi Yang, Qiong Wu, Jie Liu, Chengwu Zhang, Lin Li,* Shao Q. Yao* 237. Stimuli-Responsive Self-Assembled Prodrugs in Cancer Therapy Chem. Sci. (2022), 13, 4239-4269. Xiao Dong*, Rajeev K. Brahma, Chao Fang, Shao Q. Yao* 236.Emerging Biosensing and Transducing Techniques for Potential Applications in Point-of-Care Diagnostics Chem. Sci. (2022), 13, 2857-2876. Junjie Qin*, Wei Wang, Liqian Gao, Shao Q. Yao* 235.CPD-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery Chem. Commun. 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Zi Ye, Ke Wang, Xiaofeng Jin, Lianguo Chen, Hao Chen, Guanghui Tang, Shao Q. Yao, Zhiqiang Feng,* Chong-Jing Zhang* Year 2021 230. Engineered Cell-Penetrating Peptides for Mitochondrion-Targeted Drug Delivery in Cancer Therapy Chem. Eur. J. (2021), 27, 14721-14729. Qicai Xiao,* Xiao Dong, Fen Yang, Shizhe Zhou, Menghua Xiang, Liang Lou, Liqian Gao,* Shao Q. Yao* 229. Broad-Spectrum Polymeric Nanoquencher as An Efficient Fluorescence Sensing Platform for Biomolecular Detection ACS Sens. (2021), 6, 3102-3111. Xiao Dong, Sing Yee Ong, Changyu Zhang, Wenqiang Chen, Shubo Du, Qicai Xiao, Liqian Gao, Shao Q. Yao,* 228. Live-Cell Imaging of Survivin mRNA by Using a Dual-Color Surface-Crosslinked Micellar Nanoquencher Anal. Chem. (2021), 93, 12081-12089. Changyu Zhang, Xiao Dong, Sing Yee Ong, Shao Q. Yao* 227. A Cell-Penetrating Mitochondrion-Targeting Ligand for Universal Delivery of Small Molecules, Proteins and Nanomaterials Chem. Eur. J. (2021), 27, 12207-12214. 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(with J. Chmielewski) 9. A pH-tunable peptide ligase. Biopolymer (1999) 51, 370-375. Yao, S., Chmielewski, J. 8. DNA Binding Peptides Comprehensive Natural Products Chemistry (1999) 7, 477-490. Ghosh, I., Yao, S., Chmielewski, J. 7. Selective amplificationbyauto- and cross-catalysis in a replicating peptide system. Nature (1998) 396, 447-450. Yao, S., Ghosh, I., Zutshi, R., Chmielewski, J. See also Chem. & Eng. News (1998) 76, No.49, 40. 6. A Self-replicating peptide under ionic control. Angew. Chem. Int. Ed. Eng. (1998) 37, 478-481. (Angew. Chem. (1998) 110, 489-492.) Yao, S., Ghosh, I., Zutshi, R., Chmielewski, J. 5. Endothiopeptide inhibitors of HIV-1 protease. Bioorg. Med. Chem. Lett. (1998) 8, 699-704. Yao, S., Zutshi, R., Chmielewski, J. 4. Uncoilingc-Jun coiled-coils: inhibitory effects of truncated Fos peptides on Jun dimerization and DNA bindingin vitro. Biopolymer (1998) 47, 277-283. Yao, S., Brickner, M., Pares-Matos, E. & Chmielewski, J. 3. Inhibiting dimerization and DNA binding of c-Jun oncoprotein. Peptides: Frontiers of Peptide Science (1998) 15, 751-752. Yao, S., Chmielewski, J. 2. Natural selection with self-replicating peptides. Peptides: Frontiers of Peptide Science, (1998) 15, 366-368. Yao, S., Ghosh, I., Chmielewski, J. 1. A pH-modulated, self-replicating peptide. J. Am. Chem. Soc. (1997) 119, 10559-10560. Yao, S., Ghosh I., Zutshi, R., Chmielewski, J. See also Chem. & Eng. News 1997, 75, No.44, 21. BOOK CHAPTERS 1. Peptide-Based Microarray in Microarrays: New Development Towards Recognition of Nucleic Acid and Protein Signatures, 2007 (K. Dill, et al ed.), Springer Verlag/Kluwer. Panicker, R.C.; Sun, H.; Chen, G.Y.J.; Yao, S.Q.* 2. Protein Engineering for Surface Attachment in Functional Protein Microarrays: Pathways to Discovery, 2006 (P. Predki, ed.), CRC press. Girish, A.; Chen, G.Y.J.; Yao, S.Q.* 3. Enzyme Assays on Chips. in Enzyme Assays and Enzyme Profiling: Wiley, 2005 (J.L. Reymond Ed). Chattopadhaya, S.; Yao, S.Q.* 4. Novel strategies in protein microarray generation and detection. in Protein Microarray: Jones and Barlett Publishers, 2004. (Schena Ed.) Lue, Y.P.R. Yeo, S.Y.D., Tan, L.P., Uttamchandani, M., Chen, G.Y.J., Yao, S.Q.* 5. Site-specific immobilization of proteins in a microarray. in The Proteomics Protocols Handbook (J.M. Walker, ed), Humana Press (Totowa, NJ), 2005, Chapter 63, pp. 747-756. Lue, Y.P.R., Yeo, S.Y.D., Tan, L.P., Chen, G.Y.J., Yao, S.Q.* PATENTS 1.Site-Specific Labelling of Proteins US Patent No. 7,449,558, granted (on Nov 11, 2008). Yao, S.Q. & Yeo, S.Y.D. 2.Novel strategies for site-specific immobilization of peptides and proteins onto glass slides. US patent, submitted (2003). Lesaicherre, M.L. et al. Yao, S.Q. 3.Novel methods for detecting enzymatic activity on a protein microarray. US patent, submitted (2003). Uttamchandani, M.; Chen, G.Y.J.; Yao, S.Q. 4.Gel electrophoresis of proteins in microchannels. US patent, provisional (2000). Anex, D.S. & Yao S. |
