Publication

2023

  • Assessing the external validity of machine learning-based detection of glaucoma Li C, Chua J, Schwarzhans F, Husain R, Girard MJA, Majithia S, Tham YC, Cheng CY, Aung T, Fischer G, Vass C, Bujor I, Kwoh CK, Popa-Cherecheanu A, Schmetterer L, Wong D. Sci Rep, 2023 Jan 11; 13(1): 558.
  • Rare variant analyses across multiethnic cohorts identify novel genes for refractive error Musolf AM, Haarman AEG, Luben RN, Ong JS, Patasova K, Trapero RH, Marsh J, Jain I, Jain R, Wang PZ, Lewis DD, Tedja MS, Iglesias AI, Li H, Cowan CS, Consortium for Refractive Error and Myopia (CREAM), Biino G, Klein AP, Duggal P, Mackey DA, Hayward C, Haller T, Metspalu A, Wedenoja J, Parssinen O, Cheng CY, Saw SM, Stambolian D, Hysi PG, Khawaja AP, Vitart V, Hammond CJ, van Duijn CM, Verhoeven VJM, Klaver CCW, Bailey-Wilson JE. Commun Biol, 2023 Jan 3; 6(1): 6.
  • Validation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank Tseng R, Rim TH, Shantsila E, Yi JK, Park S, Kim SS, Lee CJ, Thakur S, Nusinovici S, Peng Q, Kim H, Lee G, Yu M, Tham YC, Bakhai A, Leeson P, Lip GYH, Wong TY, Cheng CY. BMC Med, 2023 Jan 24; 21(1): 28.
  • Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness Fenner BJ, Li H, Gan ATL, Song YS, Tham YC, Jonas JB, Wang YX, Cheng CY, Wong TY, Teo KYC, Tan ACS, Fan Q, Cheung CMG. Invest Ophthalmol Vis Sci, 2023 Feb 1; 64(2): 10.
  • From 2 dimensions to 3rd dimension: Quantitative prediction of anterior chamber depth from anterior segment photographs via deep-learning Soh ZD, Jiang Y, SS SOG, Zhou M, Nongiur M, Majithia S, Tham YC, Rim TH, Qian C, Koh V, Aung T, Wong TY, Xu X, Liu Y, Cheng CY. PLOS Digit Health, 2023 Feb; 2(2): e0000193.
  • Pattern and Characteristics of Drusen Subtypes in Chinese and Indian Populations in Singapore Takahashi K, Song Y, Cheong KX, Fenner BJ, Teo KYC, Chee ML, Li H, Tham YC, Cheung CMG, Cheng CY, Wong TY, Yanagi Y, Tan ACS. Retina, 2023 Feb 1; 43(2): 303-312.
  • Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Rayner NW, Bocher O, Ana Luiza de SVA, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Alaine Broadaway K, Williamson A, Kamali Z, Cui J, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, Janaka de Silva H, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, Gonzalez-Villalpando C, Gonzalez-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Han S, Hattersley AT, Herder C, Horikoshi M, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jorgensen T, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kronenberg F, Kuusisto J, Lall K, Lange LA, Lee KM, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Lithgart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Metspalu A, Mo H, Morris AD, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schonherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stancakova A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan JM, Yusuf S, Zawistowski M, Zhang L, Zheng W, Va Million Veteran Program Amed Grifin Diabetes Initiative Japan, Project B.J., BioBank P.M., Center R.G., Consortium E, International Consortium for Blood Pressure, Meta-Analyses of Glucose Insulin-Related Traits Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu JY, Geoffrey Hayes M, Ma RCW, Wong TY, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Pare G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, Chen YI, Rich SS, McKean-Cowdin R, Grallert H, Cheng CY, Ghanbari M, Tai ES, Dupuis J, Kato N, Laakso M, Kottgen A, Koh WP, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim BJ, Millwood IY, Walters RG, Stefansson K, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zollner S, Magi R, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang KM, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E. medRxiv, 2023 Mar 31.
  • Relationship between vision impairment and employment Chai YX, Gan ATL, Fenwick EK, Sui AY, Tan BKJ, Quek DQY, Qian C, Wong TY, Cheng CY, Lamoureux EL, Man REK. Br J Ophthalmol, 2023 Mar; 107(3): 361-366.
  • Six-year incidence of age-related macular degeneration and correlation to OCT-derived drusen volume measurements in a Chinese population Tan AC, Chee ML, Fenner BJ, Mitchell P, Tham YC, Rim T, Teo K, Sim SS, Cheng CY, Wong TY, Chakravarthy U, Cheung CMG. Br J Ophthalmol, 2023 Mar; 107(3): 392-398.
  • Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Tregouet DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bulow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Munoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdes Hernandez MC, Vernooij MW, Volker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Charge Consortium, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Nat Med, 2023 Apr; 29(4): 950-962.
  • Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: a CKD Prognosis Consortium study Mark PB, Carrero JJ, Matsushita K, Sang Y, Ballew SH, Grams ME, Coresh J, Surapaneni A, Brunskill NJ, Chalmers J, Chan L, Chang AR, Chinnadurai R, Chodick G, Cirillo M, de Zeeuw D, Evans M, Garg AX, Gutierrez OM, Heerspink HJL, Heine GH, Herrington WG, Ishigami J, Kronenberg F, Lee JY, Levin A, Major RW, Marks A, Nadkarni GN, Naimark DMJ, Nowak C, Rahman M, Sabanayagam C, Sarnak M, Sawhney S, Schneider MP, Shalev V, Shin JI, Siddiqui MK, Stempniewicz N, Sumida K, Valdivielso JM, van den Brand J, Yee-Moon Wang A, Wheeler DC, Zhang L, Visseren FLJ, Stengel B. Eur Heart J, 2023 Apr 1; 44(13): 1157-1166.
  • A five-safes approach to a secure and scalable genomics data repository Shih CC, Chen J, Lee AS, Bertin N, Hebrard M, Khor CC, Li Z, Juan Tan JH, Meah WY, Peh SQ, Mok SQ, Sim KS, Liu J, Wang L, Wong E, Li J, Tin A, Cheng CY, Heng CK, Yuan JM, Koh WP, Saw SM, Friedlander Y, Sim X, Chai JF, Chong YS, Davila S, Goh LL, Lee ES, Wong TY, Karnani N, Leong KP, Yeo KK, Chambers JC, Lim SC, Goh RSM, Tan P, Dorajoo R. iScience, 2023 Apr 21; 26(4): 106546.
  • Mendelian Randomization Implicates Bidirectional Association between Myopia and Primary Open-Angle Glaucoma or Intraocular Pressure Chong RS, Li H, Cheong AJY, Fan Q, Koh V, Raghavan L, Nongpiur ME, Cheng CY. Ophthalmology, 2023 Apr; 130(4): 394-403.
  • Cardiovascular disease risk assessment using a deep-learning-based retinal biomarker: a comparison with existing risk scores Yi JK, Rim TH, Park S, Kim SS, Kim HC, Lee CJ, Kim H, Lee G, Lim JSG, Tan YY, Yu M, Tham YC, Bakhai A, Shantsila E, Leeson P, Lip GYH, Chin CWL, Cheng CY. Eur Heart J Digit Health, 2023 May; 4(3): 236-244.
  • A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia Jiang C, Melles RB, Yin J, Fan Q, Guo X, Cheng CY, He M, Mackey DA, Guggenheim JA, Klaver C, Consortium for Refractive Error and Myopia (CREAM), Nair KS, Jorgenson E, Choquet H. Front Genet, 2023; 14: 1113058.

2022

  • Identification of novel loci influencing refractive error in East Asian populations using an extreme phenotype design Han X, Liu T, Ding X, Liu J, Lin X, Wang D, Riaz M, Baird PN, Xie Z, Cheng Y, Li Y, Mori Y, Miyake M, Li H, Cheng CY, Zeng C, Ohno-Matsui K, Zhou X, Liu F, He M. J Genet Genomics, 2022 Jan; 49(1): 54-62.
  • Prevalence of Polypoidal Choroidal Vasculopathy Using Non-indocyanine green angiography-based Criteria Fenner BJ, Teo KYC, Tham YC, Chakravarthy U, Cheung CMG. Ophthalmol Retina, 2022 Feb; 6(2): 179-181.
  • Machine learning to determine relative contribution of modifiable and non-modifiable risk factors of major eye diseases Nusinovici S, Zhang L, Chai X, Zhou L, Tham YC, Vasseneix C, Majithia S, Sabanayagam C, Wong TY, Cheng CY. Br J Ophthalmol, 2022 Feb; 106(2): 267-274.
  • Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies Sun Q, Graff M, Rowland B, Wen J, Huang L, Miller-Fleming TW, Haessler J, Preuss MH, Chai JF, Lee MP, Avery CL, Cheng CY, Franceschini N, Sim X, Cox NJ, Kooperberg C, North KE, Li Y, Raffield LM. J Hum Genet, 2022 Feb; 67(2): 87-93.
  • Three-dimensional modelling of the choroidal angioarchitecture in a multi-ethnic Asian population Cheong KX, Teo KYC, Tham YC, Sim R, Majithia S, Lee JM, Tan ACS, Cheng CY, Cheung CMG, Agrawal R. Sci Rep, 2022 Mar 9; 12(1): 3831.
  • Normative profiles of neuroretinal rim area in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases study Lim ZW, Chee ML, Lim SH, Thakur S, Majithia S, Soh ZD, Teo ZL, Rim TH, Sabanayagam C, Tham YC, Cheng CY. Br J Ophthalmol, 2022 Mar; 106(3): 381-387.
  • High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma: Metabolomics and Mendelian Randomization Analyses Nusinovici S, Li H, Thakur S, Baskaran M, Tham YC, Zhou L, Sabanayagam C, Aung T, Silver D, Fan Q, Wong TY, Crowston J, Cheng CY. Ophthalmology, 2022 Mar; 129(3): 285-294.
  • Detecting visually significant cataract using retinal photograph-based deep learning Tham YC, Goh JHL, Anees A, Lei X, Rim TH, Chee ML, Wang YX, Jonas JB, Thakur S, Teo ZL, Cheung N, Hamzah H, Tan GSW, Husain R, Sabanayagam C, Wang JJ, Chen Q, Lu Z, Keenan TD, Chew EY, Tan AG, Mitchell P, Goh RSM, Xu X, Liu Y, Wong TY, Cheng CY. Nat Aging, 2022 Mar; 2(3): 264-271.
  • Cerebral Microbleeds, Cerebral Amyloid Angiopathy, and Their Relationships to Quantitative Markers of Neurodegeneration Beaman C, Kozii K, Hilal S, Liu M, Spagnolo-Allende AJ, Polanco-Serra G, Chen C, Cheng CY, Zambrano D, Arikan B, Del Brutto VJ, Wright C, Flowers XE, Leskinen SP, Rundek T, Mitchell A, Vonsattel JP, Cortes E, Teich AF, Sacco RL, Elkind MSV, Roh D, Gutierrez J, Alzheimer’s Disease Neuroimaging Initiative. Neurology, 2022 Apr 19; 98(16): e1605-e1616.
  • Identification of genetic effects underlying type 2 diabetes in South Asian and European populations Loh M, Zhang W, Ng HK, Schmid K, Lamri A, Tong L, Ahmad M, Lee JJ, Ng MCY, Petty LE, Spracklen CN, Takeuchi F, Islam MT, Jasmine F, Kasturiratne A, Kibriya M, Mohlke KL, Pare G, Prasad G, Shahriar M, Chee ML, de Silva HJ, Engert JC, Gerstein HC, Mani KR, Sabanayagam C, Vujkovic M, Wickremasinghe AR, Wong TY, Yajnik CS, Yusuf S, Ahsan H, Bharadwaj D, Anand SS, Below JE, Boehnke M, Bowden DW, Chandak GR, Cheng CY, Kato N, Mahajan A, Sim X, McCarthy MI, Morris AP, Kooner JS, Saleheen D, Chambers JC. Commun Biol, 2022 Apr 7; 5(1): 329.
  • Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes Wang X, Tun TA, Nongpiur ME, Htoon HM, Tham YC, Strouthidis NG, Aung T, Cheng CY, Girard MJ. Br J Ophthalmol, 2022 Apr; 106(4): 491-496.
  • Predictors of myopic macular degeneration in a 12-year longitudinal study of Singapore adults with myopia Foo LL, Xu L, Sabanayagam C, Htoon HM, Ang M, Zhang J, Ohno-Matsui K, Cheng CY, Hoang QV, Tan CS, Saw SM, Wong CW. Br J Ophthalmol, 2022 May 9.
  • Different impact of early and late stages irreversible eye diseases on vision-specific quality of life domains Gupta P, Fenwick EK, Man REK, Gan ATL, Sabanayagam C, Quek D, Qian C, Cheung CMG, Cheng CY, Lamoureux EL. Sci Rep, 2022 May 19; 12(1): 8465.
  • DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity Keenan TDL, Chen Q, Agron E, Tham YC, Goh JHL, Lei X, Ng YP, Liu Y, Xu X, Cheng CY, Bikbov MM, Jonas JB, Bhandari S, Broadhead GK, Colyer MH, Corsini J, Cousineau-Krieger C, Gensheimer W, Grasic D, Lamba T, Magone MT, Maiberger M, Oshinsky A, Purt B, Shin SY, Thavikulwat AT, Lu Z, Chew EY, Areds Deep Learning Research Group. Ophthalmology, 2022 May; 129(5): 571-584.
  • A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study Lu X, Liu Z, Cui Q, Liu F, Li J, Niu X, Shen C, Hu D, Huang K, Chen J, Xing X, Zhao Y, Lu F, Liu X, Cao J, Chen S, Ma H, Yu L, Wu X, Wu X, Li Y, Zhang H, Mo X, Zhao L, Huang J, Wang L, Wen W, Shu XO, Takeuchi F, Koh WP, Tai ES, Cheng CY, Wong TY, Chang X, Chan MY, Gao W, Zheng H, Chen K, Chen J, He J, Tang CS, Lam KSL, Tse HF, Cheung CYY, Takahashi A, Kubo M, Kato N, Terao C, Kamatani Y, Sham PC, Heng CK, Hu Z, Chen YE, Wu T, Shen H, Willer CJ, Gu D. Eur Heart J, 2022 May 7; 43(18): 1702-1711.
  • Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rueger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, Gonzalez-Villalpando C, Gonzalez-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jorgensen ME, Jorgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Lall K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schonherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stancakova A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, FinnGen e Merge Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Pare G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Kottgen A, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Magi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP. Nat Genet, 2022 May; 54(5): 560-572.
  • Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians: Pooled Analysis from the Asian Eye Epidemiology Consortium Majithia S, Tham YC, Chong CCY, Yu M, Cheung CY, Bikbov MM, Kazakbaeva GM, Wang N, Hao J, Cao K, Wang YX, Sasaki M, Ito Y, Wong IY, Cheuk-Hung Chan J, Khanna RC, Marmamula S, Nakano E, Mori Y, Aung T, Wong TY, Jonas JB, Miyake M, Cheng CY, of the Asian Eye Epidemiology Consortium. Ophthalmology, 2022 May; 129(5): 552-561.
  • Machine learning identifying peripheral circulating metabolites associated with intraocular pressure alterations Qian C, Nusinovici S, Thakur S, Soh ZD, Majithia S, Chee ML, Zhong H, Tham YC, Sabanayagam C, Hysi PG, Cheng CY.Br J Ophthalmol, 2022 May 25.
  • The longitudinal association between cognitive impairment and incident visual impairment in a multiethnic Asian population: a prospective cohort study Vu TA, Gupta P, Leow FZY, Fenwick EK, Man REK, Tham YC, Xu X, Quek DQY, Qian C, Sabanayagam C, Chen CLH, Wong TY, Cheng CY, Lamoureux EL. Age Ageing, 2022 May 1; 51(5).
  • Multivariate Normative Comparison, a Novel Method for Improved Use of Retinal Nerve Fiber Layer Thickness to Detect Early Glaucoma Chua J, Schwarzhans F, Wong D, Li C, Husain R, Crowston JG, Perera SA, Sng CCA, Nongpiur ME, Majithia S, Tham YC, Thakur S, Da Soh Z, Cheng CY, Aung T, Fischer G, Vass C, Schmetterer L. Ophthalmol Glaucoma, 2022 May-Jun; 5(3): 359-368.
  • Six-year incidence and systemic associations of retinopathy in a multi-ethnic Asian population without diabetes Gupta P, Lamoureux EL, Sabanayagam C, Tham YC, Tan G, Cheng CY, Wong TY, Cheung N. Br J Ophthalmol, 2022 Jun; 106(6): 845-851.
  • Circulating Metabolic Biomarkers Are Consistently Associated With Type 2 Diabetes Risk in Asian and European Populations Seah JYH, Hong Y, Cichonska A, Sabanayagam C, Nusinovici S, Wong TY, Cheng CY, Jousilahti P, Lundqvist A, Perola M, Salomaa V, Tai ES, Wurtz P, van Dam RM, Sim X. J Clin Endocrinol Metab, 2022 Jun 16; 107(7): e2751-e2761.
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I, Fornage M, Franke A, Franks PW, Freedman BI, Gasparini P, Gieger C, Girotto G, Goddard ME, Golightly YM, Gonzalez-Villalpando C, Gordon-Larsen P, Grallert H, Grant SFA, Grarup N, Griffiths L, Gudnason V, Haiman C, Hakonarson H, Hansen T, Hartman CA, Hattersley AT, Hayward C, Heckbert SR, Heng CK, Hengstenberg C, Hewitt AW, Hishigaki H, Hoyng CB, Huang PL, Huang W, Hunt SC, Hveem K, Hypponen E, Iacono WG, Ichihara S, Ikram MA, Isasi CR, Jackson RD, Jarvelin MR, Jin ZB, Jockel KH, Joshi PK, Jousilahti P, Jukema JW, Kahonen M, Kamatani Y, Kang KD, Kaprio J, Kardia SLR, Karpe F, Kato N, Kee F, Kessler T, Khera AV, Khor CC, Kiemeney L, Kim BJ, Kim EK, Kim HL, Kirchhof P, Kivimaki M, Koh WP, Koistinen HA, Kolovou GD, Kooner JS, Kooperberg C, Kottgen A, Kovacs P, Kraaijeveld A, Kraft P, Krauss RM, Kumari M, Kutalik Z, Laakso M, Lange LA, Langenberg C, Launer LJ, Le Marchand L, Lee H, Lee NR, Lehtimaki T, Li H, Li L, Lieb W, Lin X, Lind L, Linneberg A, Liu CT, Liu J, Loeffler M, London B, 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Singleton AB, Sinner MF, Smith JG, Snieder H, Spector TD, Stampfer MJ, Stark KJ, Strachan DP, t Hart LM, Tabara Y, Tang H, Tardif JC, Thanaraj TA, Timpson NJ, Tonjes A, Tremblay A, Tuomi T, Tuomilehto J, Tusie-Luna MT, Uitterlinden AG, van Dam RM, van der Harst P, Van der Velde N, van Duijn CM, van Schoor NM, Vitart V, Volker U, Vollenweider P, Volzke H, Wacher-Rodarte NH, Walker M, Wang YX, Wareham NJ, Watanabe RM, Watkins H, Weir DR, Werge TM, Widen E, Wilkens LR, Willemsen G, Willett WC, Wilson JF, Wong TY, Woo JT, Wright AF, Wu JY, Xu H, Yajnik CS, Yokota M, Yuan JM, Zeggini E, Zemel BS, Zheng W, Zhu X, Zmuda JM, Zonderman AB, Zwart JA, and Me Research Team, V.A. 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  • Analysis of clinically relevant variants from ancestrally diverse Asian genomes Chan SH, Bylstra Y, Teo JX, Kuan JL, Bertin N, Gonzalez-Porta M, Hebrard M, Tirado-Magallanes R, Tan JHJ, Jeyakani J, Li Z, Chai JF, Chong YS, Davila S, Goh LL, Lee ES, Wong E, Wong TY, S. G10K_Health Consortium, Prabhakar S, Liu J, Cheng CY, Eisenhaber B, Karnani N, Leong KP, Sim X, Yeo KK, Chambers JC, Tai ES, Tan P, Jamuar SS, Ngeow J, Lim WK. Nat Commun, 2022 Nov 5; 13(1): 6694.
  • A deep learning model for detection of Alzheimer’s disease based on retinal photographs: a retrospective, multicentre case-control study Cheung CY, Ran AR, Wang S, Chan VTT, Sham K, Hilal S, Venketasubramanian N, Cheng CY, Sabanayagam C, Tham YC, Schmetterer L, McKay GJ, Williams MA, Wong A, Au LWC, Lu Z, Yam JC, Tham CC, Chen JJ, Dumitrascu OM, Heng PA, Kwok TCY, Mok VCT, Milea D, Chen CL, Wong TY.  Lancet Digit Health, 2022 Nov; 4(11): e806-e815.
  • Normative Data and Associations of OCT Angiography Measurements of the Macula: The Singapore Malay Eye Study Teo ZL, Sun CZ, Chong CCY, Tham YC, Takahashi K, Majithia S, Teo CL, Rim TH, Chua J, Schmetterer L, Cheung CMG, Wong TY, Cheng CY, Tan ACS. Ophthalmol Retina, 2022 Nov; 6(11): 1080-1088.
  • Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans Zhong S, Chevre R, Castano Mayan D, Corliano M, Cochran BJ, Sem KP, van Dijk TH, Peng J, Tan LJ, Hartimath SV, Ramasamy B, Cheng P, Groen AK, Kuipers F, Goggi JL, Drum C, van Dam RM, Tan RS, Rye KA, Hayden MR, Cheng CY, Chacko S, Flannick J, Sim X, Tan HC, Singaraja RR. J Clin Invest, 2022 Nov 1; 132(21).
  • Deep learning algorithms for automatic detection of pterygium using anterior segment photographs from slit-lamp and hand-held cameras Fang X, Deshmukh M, Chee ML, Soh ZD, Teo ZL, Thakur S, Goh JHL, Liu YC, Husain R, Mehta JS, Wong TY, Cheng CY, Rim TH, Tham YC. Br J Ophthalmol, 2022 Dec; 106(12): 1642-1647.
  • Association Between Risk of Obstructive Sleep Apnea and Glaucoma: The Singapore Epidemiology of Eye Diseases Study Mehta A, Man REK, Gan AT, Najjar RP, Nongpiur M, Lamoureux EL, Cheng CY, Fenwick EK. J Glaucoma, 2022 Dec 1; 31(12): 935-940.
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Karhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, Matteo F, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Mollehave LT, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, Lamina C, Forer L, Scholz M, Galesloot TE, Bradfield JP, Ruotsalainen SE, Daw E, Zmuda JM, Mitchell JS, Fuchsberger C, Christensen H, Brody JA, Vazquez-Moreno M, Feitosa MF, Wojczynski MK, Wang Z, Preuss MH, Mangino M, Christofidou P, Verweij N, Benjamins JW, Engmann J, Tsao NL, Verma A, Slieker RC, Lo KS, Zilhao NR, Le P, Kleber ME, Delgado GE, Huo S, Ikeda DD, Iha H, Yang J, Liu J, Demirkan A, Leonard HL, Marten J, Frank M, Schmidt B, Smyth LJ, Canadas-Garre M, Wang C, Nakatochi M, Wong A, Hutri-Kahonen N, Sim X, Xia R, Huerta-Chagoya A, Fernandez-Lopez JC, Lyssenko V, Nongmaithem SS, Bayyana S, Stringham HM, Irvin MR, Oldmeadow C, Kim HN, Ryu S, Timmers P, Arbeeva L, Dorajoo R, Lange LA, Prasad G, Lores-Motta L, Pauper M, Long J, Li X, Theusch E, Takeuchi F, Spracklen CN, Loukola A, Bollepalli S, Warner SC, Wang YX, Wei WB, Nutile T, Ruggiero D, Sung YJ, Chen S, Liu F, Yang J, Kentistou KA, Banas B, Nardone GG, Meidtner K, Bielak LF, Smith JA, Hebbar P, Farmaki AE, Hofer E, Lin M, Concas MP, Vaccargiu S, van der Most PJ, Pitkanen N, Cade BE, van der Laan SW, Chitrala KN, Weiss S, Bentley AR, Doumatey AP, Adeyemo AA, Lee JY, Petersen ERB, Nielsen AA, Choi HS, Nethander M, Freitag-Wolf S, Southam L, Rayner NW, Wang CA, Lin SY, Wang JS, Couture C, Lyytikainen LP, Nikus K, Cuellar-Partida G, Vestergaard H, Hidalgo B, Giannakopoulou O, Cai Q, Obura MO, van Setten J, Li X, Liang J, Tang H, Terzikhan N, Shin JH, Jackson RD, Reiner AP, Martin LW, Chen Z, Li L, Kawaguchi T, Thiery J, Bis JC, Launer LJ, Li H, Nalls MA, Raitakari OT, Ichihara S, Wild SH, Nelson CP, Campbell H, Jager S, Nabika T, Al-Mulla F, Niinikoski H, Braund PS, Kolcic I, Kovacs P, Giardoglou T, Katsuya T, de Kleijn D, de Borst GJ, Kim EK, Adams HHH, Ikram MA, Zhu X, Asselbergs FW, Kraaijeveld AO, Beulens JWJ, Shu XO, Rallidis LS, Pedersen O, Hansen T, Mitchell P, Hewitt AW, Kahonen M, Perusse L, Bouchard C, Tonjes A, Chen YI, Pennell CE, Mori TA, Lieb W, Franke A, Ohlsson C, Mellstrom D, Cho YS, Lee H, Yuan JM, Koh WP, Rhee SY, Woo JT, Heid IM, Stark KJ, Zimmermann ME, Volzke H, Homuth G, Evans MK, Zonderman AB, Polasek O, Pasterkamp G, Hoefer IE, Redline S, Pahkala K, Oldehinkel AJ, Snieder H, Biino G, Schmidt R, Schmidt H, Bandinelli S, Dedoussis G, Thanaraj TA, Kardia SLR, Peyser PA, Kato N, Schulze MB, Girotto G, Boger CA, Jung B, Joshi PK, Bennett DA, De Jager PL, Lu X, Mamakou V, Brown M, Caulfield MJ, Munroe PB, Guo X, Ciullo M, Jonas JB, Samani NJ, Kaprio J, Pajukanta P, Tusie-Luna T, Aguilar-Salinas CA, Adair LS, Bechayda SA, de Silva HJ, Wickremasinghe AR, Krauss RM, Wu JY, Zheng W, Hollander AI, Bharadwaj D, Correa A, Wilson JG, Lind L, Heng CK, Nelson AE, Golightly YM, Wilson JF, Penninx B, Kim HL, Attia J, Scott RJ, Rao DC, Arnett DK, Hunt SC, Walker M, Koistinen HA, Chandak GR, Mercader JM, Costanzo MC, Jang D, Burtt NP, Villalpando CG, Orozco L, Fornage M, Tai E, van Dam RM, Lehtimaki T, Chaturvedi N, Yokota M, Liu J, Reilly DF, McKnight AJ, Kee F, Jockel KH, McCarthy MI, Palmer CNA, Vitart V, Hayward C, Simonsick E, van Duijn CM, Jin ZB, Qu J, Hishigaki H, Lin X, Marz W, Gudnason V, Tardif JC, Lettre G, Hart LM, Elders PJM, Damrauer SM, Kumari M, Kivimaki M, van der Harst P, Spector TD, Loos RJF, Province MA, Parra EJ, Cruz M, Psaty BM, Brandslund I, Pramstaller PP, Rotimi CN, Christensen K, Ripatti S, Widen E, Hakonarson H, Grant SFA, Kiemeney L, de Graaf J, Loeffler M, Kronenberg F, Gu D, Erdmann J, Schunkert H, Franks PW, Linneberg A, Jukema JW, Khera AV, Mannikko M, Jarvelin MR, Kutalik Z, Francesco C, Mook-Kanamori DO, van Dijk KW, Watkins H, Strachan DP, Grarup N, Sever P, Poulter N, Chuang LM, Rotter JI, Dantoft TM, Karpe F, Neville MJ, Timpson NJ, Cheng CY, Wong TY, Khor CC, Li H, Sabanayagam C, Peters A, Gieger C, Hattersley AT, Pedersen NL, Magnusson PKE, Boomsma DI, Willemsen AHM, Cupples L, van Meurs JBJ, Ghanbari M, Gordon-Larsen P, Huang W, Kim YJ, Tabara Y, Wareham NJ, Langenberg C, Zeggini E, Kuusisto J, Laakso M, Ingelsson E, Abecasis G, Chambers JC, Kooner JS, de Vries PS, Morrison AC, Hazelhurst S, Ramsay M, North KE, Daviglus M, Kraft P, Martin NG, Whitfield JB, Abbas S, Saleheen D, Walters RG, Holmes MV, Black C, Smith BH, Baras A, Justice AE, Buring JE, Ridker PM, Chasman DI, Kooperberg C, Tamiya G, Yamamoto M, van Heel DA, Trembath RC, Wei WQ, Jarvik GP, Namjou B, Hayes MG, Ritchie MD, Jousilahti P, Salomaa V, Hveem K, Asvold BO, Kubo M, Kamatani Y, Okada Y, Murakami Y, Kim BJ, Thorsteinsdottir U, Stefansson K, Zhang J, Chen Y, Ho YL, Lynch JA, Rader DJ, Tsao PS, Chang KM, Cho K, O’Donnell CJ, Gaziano JM, Wilson PWF, Frayling TM, Hirschhorn JN, Kathiresan S, Mohlke KL, Sun YV, Morris AP, Boehnke M, Brown CD, Natarajan P, Deloukas P, Willer CJ, Assimes TL, Peloso GM. Genome Biol, 2022 Dec 27; 23(1): 268.
  • Predictive, preventive, and personalized management of retinal fluid via computer-aided detection app for optical coherence tomography scans Quek TC, Takahashi K, Kang HG, Thakur S, Deshmukh M, Tseng R, Nguyen H, Tham YC, Rim TH, Kim SS, Yanagi Y, Liew G, Cheng CY. EPMA J, 2022 Dec; 13(4): 547-560.
  • Relationships between Lipid-Related Metabolites and Age-Related Macular Degeneration Vary with Complement Genotype Sim RZH, Tham YC, Betzler BK, Zhou L, Wang X, Sabanayagam C, Cheung GCM, Wong TY, Cheng CY, Nusinovici S. Ophthalmol Sci, 2022 Dec; 2(4): 100211.
  • Artificial Intelligence in Predicting Systemic Parameters and Diseases From Ophthalmic Imaging Betzler BK, Rim TH, Sabanayagam C, Cheng CY. Front Digit Health, 2022a; 4: 889445.
  • Impact of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) GFR Estimating Equations on CKD Prevalence and Classification Among Asians Betzler BK, Sultana R, He F, Tham YC, Lim CC, Wang YX, Nangia V, Tai ES, Rim TH, Bikbov MM, Jonas JB, Kang SW, Park KH, Cheng CY, Sabanayagam C. Front Med (Lausanne), 2022b; 9: 957437.
  • The discriminant validity of single-question assessments of subjective cognitive complaints in an Asian older adult population Pang T, Zhao X, He X, Kan CN, Venketasubramanian N, Cheng CY, Yuan C, Chen C, Xu X. Front Aging Neurosci, 2022; 14: 901592.
  • Three-Dimensional Multi-Task Deep Learning Model to Detect Glaucomatous Optic Neuropathy and Myopic Features From Optical Coherence Tomography Scans: A Retrospective Multi-Centre Study Ran AR, Wang X, Chan PP, Chan NC, Yip W, Young AL, Wong MOM, Yung HW, Chang RT, Mannil SS, Tham YC, Cheng CY, Chen H, Li F, Zhang X, Heng PA, Tham CC, Cheung CY. Front Med (Lausanne), 2022; 9: 860574.

2021

  • Ethnic differences in the incidence of pterygium in a multi-ethnic Asian population: the Singapore Epidemiology of Eye Diseases Study Fang XL, Chong CCY, Thakur S, Da Soh Z, Teo ZL, Majithia S, Lim ZW, Rim TH, Sabanayagam C, Wong TY, Cheng CY, Tham YC. Sci Rep, 2021 Jan 12; 11(1): 501.
  • Referral for disease-related visual impairment using retinal photograph-based deep learning: a proof-of-concept, model development study Tham YC, Anees A, Zhang L, Goh JHL, Rim TH, Nusinovici S, Hamzah H, Chee ML, Tjio G, Li S, Xu X, Goh R, Tang F, Cheung CY, Wang YX, Nangia V, Jonas JB, Gopinath B, Mitchell P, Husain R, Lamoureux E, Sabanayagam C, Wang JJ, Aung T, Liu Y, Wong TY, Cheng CY. Lancet Digit Health, 2021 Jan; 3(1): e29-e40.
  • Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segre AV, Rouhana JM, Hamel AR, Igo RP, Jr., Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens A, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN, Neighborhood Consortium, Anzrag Consortium, Biobank Japan project, FinnGen study, U.K. Biobank Eye Vision Consortium, Giga study group, Me Research Team, Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. Nat Commun, 2021 Feb 24; 12(1): 1258.
  • The Impact of Strategic White Matter Hyperintensity Lesion Location on Language Hilal S, Biesbroek JM, Vrooman H, Chong E, Kuijf HJ, Venketasubramanian N, Cheng CY, Wong TY, Biessels GJ, Chen C. Am J Geriatr Psychiatry, 2021 Feb; 29(2): 156-165.
  • Prevalence of retinitis pigmentosa in Singapore: the Singapore Epidemiology of Eye Diseases Study Teo CL, Cheung N, Poh S, Thakur S, Rim TH, Cheng CY, Tham YC. Acta Ophthalmol, 2021 Feb; 99(1): e134-e135.
  • Association of Antihypertensive Medication with Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Chong RS, Chee ML, Tham YC, Majithia S, Thakur S, Teo ZL, Da Soh Z, Chua J, Tan B, Wong DWK, Schmetterer L, Sabanayagam C, Cheng CY. Ophthalmology, 2021 Mar; 128(3): 393-400.
  • Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci for Estimating Angle Closure Disease Severity Liu C, Nongpiur ME, Cheng CY, Khor CC, Yu M, Husain R, Ho CL, Wong TT, Boey PY, Perera S, Wong TY, Vithana EN, Aung T. Ophthalmology, 2021 Mar; 128(3): 403-409.
  • Role of socio-economic factors in visual impairment and progression of diabetic retinopathy Low JR, Gan ATL, Fenwick EK, Gupta P, Wong TY, Teo ZL, Thakur S, Tham YC, Sabanayagam C, Cheng CY, Lamoureux EL, Man REK. Br J Ophthalmol, 2021 Mar; 105(3): 420-425.
  • A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber with reduced kidney function Lye WK, Paterson E, Patterson CC, Maxwell AP, Binte Mohammed Abdul RB, Tai ES, Cheng CY, Kayama T, Yamashita H, Sarnak M, Shlipak M, Matsushita K, Mutlu U, Ikram MA, Klaver C, Kifley A, Mitchell P, Myers C, Klein BE, Klein R, Wong TY, Sabanayagam C, McKay GJ. Kidney Int, 2021 Mar; 99(3): 696-706.
  • Cohort Profile: The Singapore Epidemiology of Eye Diseases study (SEED) Majithia S, Tham YC, Chee ML, Nusinovici S, Teo CL, Chee ML, Thakur S, Soh ZD, Kumari N, Lamoureux E, Sabanayagam C, Wong TY, Cheng CY. Int J Epidemiol, 2021 Mar 3; 50(1): 41-52.
  • The Differential Impact of Age on Vision-Related Quality of Life across the Visual Impairment Spectrum Man REK, Gan ATL, Fenwick EK, Gupta P, Thakur S, Fang XL, Cheng CY, Wong TY, Lamoureux EL. Ophthalmology, 2021 Mar; 128(3): 354-363.
  • Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations Nusinovici S, Sabanayagam C, Lee KE, Zhang L, Cheung CY, Tai ES, Tan GSW, Cheng CY, Klein BEK, Wong TY. Sci Rep, 2021 Mar 1; 11(1): 4898.
  • Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color Simcoe M, Valdes A, Liu F, Furlotte NA, Evans DM, Hemani G, Ring SM, Smith GD, Duffy DL, Zhu G, Gordon SD, Medland SE, Vuckovic D, Girotto G, Sala C, Catamo E, Concas MP, Brumat M, Gasparini P, Toniolo D, Cocca M, Robino A, Yazar S, Hewitt A, Wu W, Kraft P, Hammond CJ, Shi Y, Chen Y, Zeng C, Klaver CCW, Uitterlinden AG, Ikram MA, Hamer MA, van Duijn CM, Nijsten T, Han J, Mackey DA, Martin NG, Cheng CY, and Me Research Team, International Visible Trait Genetics Consortium, Hinds DA, Spector TD, Kayser M, Hysi PG. Sci Adv, 2021 Mar; 7(11).
  • Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study Tun TA, Wang X, Baskaran M, Nongpiur ME, Tham YC, Nguyen DQ, Strouthidis NG, Aung T, Cheng CY, Boote C, Girard MJA. Br J Ophthalmol, 2021 Mar; 105(3): 367-373.
  • Factors affecting the diagnostic performance of circumpapillary retinal nerve fibre layer measurement in glaucoma Wong D, Chua J, Baskaran M, Tan B, Yao X, Chan S, Tham YC, Chong R, Aung T, Lamoureux EL, Vithana EN, Cheng CY, Schmetterer L. Br J Ophthalmol, 2021 Mar; 105(3): 397-402.
  • Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia Zheng F, Wong CW, Sabanayagam C, Cheung YB, Matsumura S, Chua J, Man REK, Ohno-Matsui K, Wong TY, Cheng CY, Tai ES, Lamoureux E, Schmetterer L, Kuo A, Hoang QV, Saw SM. Acta Ophthalmol, 2021 Mar; 99(2): e144-e153.
  • Six-Year Incidence and Risk Factors of Primary Glaucoma in the Singapore Indian Eye Study Koh V, Tham YC, Tan NYQ, Yu M, Thakur S, Teo ZL, Mani B, Wong TY, Aung T, Cheng CY. Ophthalmol Glaucoma, 2021 Mar-Apr; 4(2): 201-208.
  • Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline Gorski M, Jung B, Li Y, Matias-Garcia PR, Wuttke M, Coassin S, Thio CHL, Kleber ME, Winkler TW, Wanner V, Chai JF, Chu AY, Cocca M, Feitosa MF, Ghasemi S, Hoppmann A, Horn K, Li M, Nutile T, Scholz M, Sieber KB, Teumer A, Tin A, Wang J, Tayo BO, Ahluwalia TS, Almgren P, Bakker SJL, Banas B, Bansal N, Biggs ML, Boerwinkle E, Bottinger EP, Brenner H, Carroll RJ, Chalmers J, Chee ML, Chee ML, Cheng CY, Coresh J, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Franke A, Freitag-Wolf S, Gampawar P, Gansevoort RT, Ghanbari M, Gieger C, Hamet P, Ho K, Hofer E, Holleczek B, Xian Foo VH, Hutri-Kahonen N, Hwang SJ, Ikram MA, Josyula NS, Kahonen M, Khor CC, Koenig W, Kramer H, Kramer BK, Kuhnel B, Lange LA, Lehtimaki T, Lieb W, Lifelines Cohort Study, Regeneron Genetics Center, Loos RJF, Lukas MA, Lyytikainen LP, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Mychaleckyj JC, Nadkarni GN, Nauck M, Nikus K, Ning B, Nolte IM, O’Donoghue ML, Orho-Melander M, Pendergrass SA, Penninx B, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rosenkranz AR, Rossing P, Rotter JI, Sabanayagam C, Schmidt H, Schmidt R, Schottker B, Schulz CA, Sedaghat S, Shaffer CM, Strauch K, Szymczak S, Taylor KD, Tremblay J, Chaker L, van der Harst P, van der Most PJ, Verweij N, Volker U, Waldenberger M, Wallentin L, Waterworth DM, White HD, Wilson JG, Wong TY, Woodward M, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang Y, Snieder H, Wanner C, Boger CA, Kottgen A, Kronenberg F, Pattaro C, Heid IM. Kidney Int, 2021 Apr; 99(4): 926-939.
  • Association of alcohol intake with incidence and progression of diabetic retinopathy Gupta P, Fenwick EK, Sabanayagam C, Gan ATL, Tham YC, Thakur S, Man REK, Mitchell P, Wong TY, Cheng CY, Lamoureux EL. Br J Ophthalmol, 2021 Apr; 105(4): 538-542.
  • Characteristics of myopic traction maculopathy in myopic Singaporean adults Matsumura S, Sabanayagam C, Wong CW, Tan CS, Kuo A, Wong YL, Ohno-Matsui K, Wong TY, Cheng CY, Hoang QV, Saw SM. Br J Ophthalmol, 2021 Apr; 105(4): 531-537.
  • Albuminuria and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study (SCES) Lim ZW, Chee ML, Thakur S, Fang X, Soh ZD, Majithia S, Teo ZL, Sabanayagam C, Wong TY, Cheng CY, Tham YC. Br J Ophthalmol, 2021 May; 105(5): 669-673.
  • Deep-learning-based cardiovascular risk stratification using coronary artery calcium scores predicted from retinal photographs Rim TH, Lee CJ, Tham YC, Cheung N, Yu M, Lee G, Kim Y, Ting DSW, Chong CCY, Choi YS, Yoo TK, Ryu IH, Baik SJ, Kim YA, Kim SK, Lee SH, Lee BK, Kang SM, Wong EYM, Kim HC, Kim SS, Park S, Cheng CY, Wong TY. Lancet Digit Health, 2021 May; 3(5): e306-e316.
  • Patterns and Determinants of Choroidal Thickness in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study Song Y, Tham YC, Chong C, Ong R, Fenner BJ, Cheong KX, Takahashi K, Jordan-Yu JM, Teo KYC, Tan ACS, Cheng CY, Wong TY, Chakravarthy U, Yanagi Y, Cheung GCM. Ophthalmol Retina, 2021 May; 5(5): 458-467.
  • Retinal photograph-based deep learning algorithms for myopia and a blockchain platform to facilitate artificial intelligence medical research: a retrospective multicohort study Tan TE, Anees A, Chen C, Li S, Xu X, Li Z, Xiao Z, Yang Y, Lei X, Ang M, Chia A, Lee SY, Wong EYM, Yeo IYS, Wong YL, Hoang QV, Wang YX, Bikbov MM, Nangia V, Jonas JB, Chen YP, Wu WC, Ohno-Matsui K, Rim TH, Tham YC, Goh RSM, Lin H, Liu H, Wang N, Yu W, Tan DTH, Schmetterer L, Cheng CY, Chen Y, Wong CW, Cheung GCM, Saw SM, Wong TY, Liu Y, Ting DSW. Lancet Digit Health, 2021 May; 3(5): e317-e329.
  • COVID-19 awareness, knowledge and perception towards digital health in an urban multi-ethnic Asian population Teo CL, Chee ML, Koh KH, Tseng R, Majithia S, Thakur S, Gunasekeran DV, Nusinovici S, Sabanayagam C, Wong TY, Tham YC, Cheng CY. Sci Rep, 2021 May 24; 11(1): 10795.
  • The trans-ancestral genomic architecture of glycemic traits Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Magi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, Marz W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gayan J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Raffield L, Rasmussen-Torvik LJ, Rich SS, Robertson NR, Rueedi R, Ryan K, Sanna S, Saxena R, Schraut KE, Sennblad B, Setoh K, Smith AV, Sparso T, Strawbridge RJ, Takeuchi F, Tan J, Trompet S, van den Akker E, van der Most PJ, Verweij N, Vogel M, Wang H, Wang C, Wang N, Warren HR, Wen W, Wilsgaard T, Wong A, Wood AR, Xie T, Zafarmand MH, Zhao JH, Zhao W, Amin N, Arzumanyan Z, Astrup A, Bakker SJL, Baldassarre D, Beekman M, Bergman RN, Bertoni A, Bluher M, Bonnycastle LL, Bornstein SR, Bowden DW, Cai Q, Campbell A, Campbell H, Chang YC, de Geus EJC, Dehghan A, Du S, Eiriksdottir G, Farmaki AE, Franberg M, Fuchsberger C, Gao Y, Gjesing AP, Goel A, Han S, Hartman CA, Herder C, Hicks AA, Hsieh CH, Hsueh WA, Ichihara S, Igase M, Ikram MA, Johnson WC, Jorgensen ME, Joshi PK, Kalyani RR, Kandeel FR, Katsuya T, Khor CC, Kiess W, Kolcic I, Kuulasmaa T, Kuusisto J, Lall K, Lam K, Lawlor DA, Lee NR, Lemaitre RN, Li H, Lifelines Cohort Study, Lin SY, Lindstrom J, Linneberg A, Liu J, Lorenzo C, Matsubara T, Matsuda F, Mingrone G, Mooijaart S, Moon S, Nabika T, Nadkarni GN, Nadler JL, Nelis M, Neville MJ, Norris JM, Ohyagi Y, Peters A, Peyser PA, Polasek O, Qi Q, Raven D, Reilly DF, Reiner A, Rivideneira F, Roll K, Rudan I, Sabanayagam C, Sandow K, Sattar N, Schurmann A, Shi J, Stringham HM, Taylor KD, Teslovich TM, Thuesen B, Timmers P, Tremoli E, Tsai MY, Uitterlinden A, van Dam RM, van Heemst D, van Hylckama Vlieg A, van Vliet-Ostaptchouk JV, Vangipurapu J, Vestergaard H, Wang T, Willems van Dijk K, Zemunik T, Abecasis GR, Adair LS, Aguilar-Salinas CA, Alarcon-Riquelme ME, An P, Aviles-Santa L, Becker DM, Beilin LJ, Bergmann S, Bisgaard H, Black C, Boehnke M, Boerwinkle E, Bohm BO, Bonnelykke K, Boomsma DI, Bottinger EP, Buchanan TA, Canouil M, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Cheng CY, Collins FS, Correa A, Cucca F, de Silva HJ, Dedoussis G, Elmstahl S, Evans MK, Ferrannini E, Ferrucci L, Florez JC, Franks PW, Frayling TM, Froguel P, Gigante B, Goodarzi MO, Gordon-Larsen P, Grallert H, Grarup N, Grimsgaard S, Groop L, Gudnason V, Guo X, Hamsten A, Hansen T, Hayward C, Heckbert SR, Horta BL, Huang W, Ingelsson E, James PS, Jarvelin MR, Jonas JB, Jukema JW, Kaleebu P, Kaplan R, Kardia SLR, Kato N, Keinanen-Kiukaanniemi SM, Kim BJ, Kivimaki M, Koistinen HA, Kooner JS, Korner A, Kovacs P, Kuh D, Kumari M, Kutalik Z, Laakso M, Lakka TA, Launer LJ, Leander K, Li H, Lin X, Lind L, Lindgren C, Liu S, Loos RJF, Magnusson PKE, Mahajan A, Metspalu A, Mook-Kanamori DO, Mori TA, Munroe PB, Njolstad I, O’Connell JR, Oldehinkel AJ, Ong KK, Padmanabhan S, Palmer CNA, Palmer ND, Pedersen O, Pennell CE, Porteous DJ, Pramstaller PP, Province MA, Psaty BM, Qi L, Raffel LJ, Rauramaa R, Redline S, Ridker PM, Rosendaal FR, Saaristo TE, Sandhu M, Saramies J, Schneiderman N, Schwarz P, Scott LJ, Selvin E, Sever P, Shu XO, Slagboom PE, Small KS, Smith BH, Snieder H, Sofer T, Sorensen TIA, Spector TD, Stanton A, Steves CJ, Stumvoll M, Sun L, Tabara Y, Tai ES, Timpson NJ, Tonjes A, Tuomilehto J, Tusie T, Uusitupa M, van der Harst P, van Duijn C, Vitart V, Vollenweider P, Vrijkotte TGM, Wagenknecht LE, Walker M, Wang YX, Wareham NJ, Watanabe RM, Watkins H, Wei WB, Wickremasinghe AR, Willemsen G, Wilson JF, Wong TY, Wu JY, Xiang AH, Yanek LR, Yengo L, Yokota M, Zeggini E, Zheng W, Zonderman AB, Rotter JI, Gloyn AL, McCarthy MI, Dupuis J, Meigs JB, Scott RA, Prokopenko I, Leong A, Liu CT, Parker SCJ, Mohlke KL, Langenberg C, Wheeler E, Morris AP, Barroso I, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC). Nat Genet, 2021 Jun; 53(6): 840-860.
  • A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre Cheung CY, Xu D, Cheng CY, Sabanayagam C, Tham YC, Yu M, Rim TH, Chai CY, Gopinath B, Mitchell P, Poulton R, Moffitt TE, Caspi A, Yam JC, Tham CC, Jonas JB, Wang YX, Song SJ, Burrell LM, Farouque O, Li LJ, Tan G, Ting DSW, Hsu W, Lee ML, Wong TY.Nat Biomed Eng, 2021 Jun; 5(6): 498-508.
  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H, Bartz TM, Bielak LF, Campbell A, Cheng CY, Dorajoo R, Hartwig FP, Horimoto A, Li C, Li-Gao R, Liu Y, Marten J, Musani SK, Ntalla I, Rankinen T, Richard M, Sim X, Smith AV, Tajuddin SM, Tayo BO, Vojinovic D, Warren HR, Xuan D, Alver M, Boissel M, Chai JF, Chen X, Christensen K, Divers J, Evangelou E, Gao C, Girotto G, Harris SE, He M, Hsu FC, Kuhnel B, Laguzzi F, Li X, Lyytikainen LP, Nolte IM, Poveda A, Rauramaa R, Riaz M, Rueedi R, Shu XO, Snieder H, Sofer T, Takeuchi F, Verweij N, Ware EB, Weiss S, Yanek LR, Amin N, Arking DE, Arnett DK, Bergmann S, Boerwinkle E, Brody JA, Broeckel U, Brumat M, Burke G, Cabrera CP, Canouil M, Chee ML, Chen YI, Cocca M, Connell J, de Silva HJ, de Vries PS, Eiriksdottir G, Faul JD, Fisher V, Forrester T, Fox EF, Friedlander Y, Gao H, Gigante B, Giulianini F, Gu CC, Gu D, Harris TB, He J, Heikkinen S, Heng CK, Hunt S, Ikram MA, Irvin MR, Kahonen M, Kavousi M, Khor CC, Kilpelainen TO, Koh WP, Komulainen P, Kraja AT, Krieger JE, Langefeld CD, Li Y, Liang J, Liewald DCM, Liu CT, Liu J, Lohman KK, Magi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Nalls MA, Nelson CP, Norris JM, O’Connell J, Ogunniyi A, Padmanabhan S, Palmer ND, Pedersen NL, Perls T, Peters A, Petersmann A, Peyser PA, Polasek O, Porteous DJ, Raffel LJ, Rice TK, Rotter JI, Rudan I, Rueda-Ochoa OL, Sabanayagam C, Salako BL, Schreiner PJ, Shikany JM, Sidney SS, Sims M, Sitlani CM, Smith JA, Starr JM, Strauch K, Swertz MA, Teumer A, Tham YC, Uitterlinden AG, Vaidya D, van der Ende MY, Waldenberger M, Wang L, Wang YX, Wei WB, Weir DR, Wen W, Yao J, Yu B, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Bowden DW, Deary IJ, Dorr M, Esko T, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kammerer CM, Kato N, Lakka TA, Leander K, Lehtimaki T, Lifelines Cohort Study, Magnusson PKE, Marques-Vidal P, Penninx B, Samani NJ, van der Harst P, Wagenknecht LE, Wu T, Zheng W, Zhu X, Bouchard C, Cooper RS, Correa A, Evans MK, Gudnason V, Hayward C, Horta BL, Kelly TN, Kritchevsky SB, Levy D, Palmas WR, Pereira AC, Province MM, Psaty BM, Ridker PM, Rotimi CN, Tai ES, van Dam RM, van Duijn CM, Wong TY, Rice K, Gauderman WJ, Morrison AC, North KE, Kardia SLR, Caulfield MJ, Elliott P, Munroe PB, Franks PW, Rao DC, Fornage M. Mol Psychiatry, 2021 Jun; 26(6): 2111-2125.
  • Vision, vision-specific functioning and mobility, and their relationship with clinically assessed cognitive impairment Fenwick EK, Gan ATL, Man REK, Gupta P, Sabanayagam C, Cheng CY, Chen CL, Cheung CY, Wong KH, Venketasubramanian N, Xu X, Hilal S, Chong EJY, Tham YC, Wong TY, Lamoureux EL. Age Ageing, 2021 Jun 28; 50(4): 1236-1242.
  • Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Cordova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garcia-Ortiz H, Gieger C, Glaser B, Gonzalez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jorgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martinez-Hernandez A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O’Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusie-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Consortia A-TDG, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O’Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Nat Commun, 2021 Jun 9; 12(1): 3505.
  • Proposal and validation of a new grading system for pterygium (SLIT2) Ting DSJ, Liu YC, Patil M, Ji AJS, Fang XL, Tham YC, Lee YF, Htoon HM, Mehta JS. Br J Ophthalmol, 2021 Jul; 105(7): 921-924.
  • The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Nael V, Narasimhalu K, Chen CLH, Lamoureux EL. Ophthalmology, 2021 Jul; 128(7): 981-992.
  • Impact of type 2 diabetes and microvascular complications on mortality and cardiovascular outcomes in a multiethnic Asian population Yap J, Anbalakan K, Tay WT, Ting D, Cheung CY, Sabanayagam C, Cheng CY, Wong TY, Yeo KK. BMJ Open Diabetes Res Care, 2021 Jul; 9(1).
  • Gender Prediction for a Multiethnic Population via Deep Learning Across Different Retinal Fundus Photograph Fields: Retrospective Cross-sectional Study Betzler BK, Yang HHS, Thakur S, Yu M, Quek TC, Soh ZD, Lee G, Tham YC, Wong TY, Rim TH, Cheng CY. JMIR Med Inform, 2021 Aug 17; 9(8): e25165.
  • White matter network damage mediates association between cerebrovascular disease and cognition Hilal S, Liu S, Wong TY, Vrooman H, Cheng CY, Venketasubramanian N, Chen CL, Zhou JH. J Cereb Blood Flow Metab, 2021 Aug; 41(8): 1858-1872.
  • Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium Wong YL, Zhu X, Tham YC, Yam JCS, Zhang K, Sabanayagam C, Lanca C, Zhang X, Han SY, He W, Susvar P, Trivedi M, Yuan N, Lambat S, Raman R, Song SJ, Wang YX, Bikbov MM, Nangia V, Chen LJ, Wong TY, Lamoureux EL, Pang CP, Cheng CY, Lu Y, Jonas JB, Saw SM, Asian Eye Epidemiology Consortium. Br J Ophthalmol, 2021 Aug; 105(8): 1140-1148.
  • APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups Goyal S, Tanigawa Y, Zhang W, Chai JF, Almeida M, Sim X, Lerner M, Chainakul J, Ramiu JG, Seraphin C, Apple B, Vaughan A, Muniu J, Peralta J, Lehman DM, Ralhan S, Wander GS, Singh JR, Mehra NK, Sidorov E, Peyton MD, Blackett PR, Curran JE, Tai ES, van Dam R, Cheng CY, Duggirala R, Blangero J, Chambers JC, Sabanayagam C, Kooner JS, Rivas MA, Aston CE, Sanghera DK. Lipids Health Dis, 2021 Sep 21; 20(1): 113.
  • Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts Quek DQY, He F, Sultana R, Banu R, Chee ML, Nusinovici S, Thakur S, Qian C, Cheng CY, Wong TY, Sabanayagam C. Metabolites, 2021 Sep 9; 11(9).
  • The Global Extent of Undetected Glaucoma in Adults: A Systematic Review and Meta-analysis Soh Z, Yu M, Betzler BK, Majithia S, Thakur S, Tham YC, Wong TY, Aung T, Friedman DS, Cheng CY. Ophthalmology, 2021 Oct; 128(10): 1393-1404.
  • Visual Impairment, Major Eye Diseases and Mortality in a Multi-Ethnic Asian Population and a Meta-analysis of Prospective Studies Ng Yin Ling C, Seshasai S, Chee ML, He F, Tham YC, Cheng CY, Wong TY, Sabanayagam C. Am J Ophthalmol, 2021 Nov; 231: 88-100.
  • Association between Body Mass Index and Chronic Kidney Disease in Asian Populations: A Participant-level Meta-Analysis Betzler BK, Sultana R, Banu R, Tham YC, Lim CC, Wang YX, Nangia V, Tai ES, Rim TH, Bikbov MM, Jonas JB, Cheng CY, Sabanayagam C. Maturitas, 2021 Dec; 154: 46-54.
  • Deep Learning Approach for Automated Detection of Myopic Maculopathy and Pathologic Myopia in Fundus Images Du R, Xie S, Fang Y, Igarashi-Yokoi T, Moriyama M, Ogata S, Tsunoda T, Kamatani T, Yamamoto S, Cheng CY, Saw SM, Ting D, Wong TY, Ohno-Matsui K. Ophthalmol Retina, 2021 Dec; 5(12): 1235-1244.
  • Application of machine learning techniques to understand ethnic differences and risk factors for incident chronic kidney disease in Asians Lim CC, He F, Li J, Tham YC, Tan CS, Cheng CY, Wong TY, Sabanayagam C. BMJ Open Diabetes Res Care, 2021 Dec; 9(2).

2020

2019

  • Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer’s Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Neurology. 2019 Jan 16;92(5):e486–503. doi: 10.1212/WNL.0000000000006851
  • Association of Diabetes With Central Corneal Thickness Among a Multiethnic Asian Population Luo XY, Dai W, Chee ML, Tao Y, Chua J, Tan NYQ, Tham YC, Aung T, Wong TY, Cheng CY. JAMA Netw Open. 2019 Jan 4;2(1):e186647. doi: 10.1001/jamanetworkopen.2018.6647
  • Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians: 6-year longitudinal study Chua J, Chee ML, Chin CWL, Tham YC, Tan N, Lim SH, Aung T, Cheng CY, Wong TY, Schmetterer LBr J Ophthalmol. 2019 Feb;103(2):196-202. doi: 10.1136/bjophthalmol-2018-311897. Epub 2018 Apr 9
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  • Variation of Peripapillary Scleral Shape With Age Tun TA, Wang X, Baskaran M, Nongpiur ME, Tham YC, Perera SA, Strouthidis NG, Aung T, Cheng CY, Girard MJA. Invest Ophthalmol Vis Sci, 2019 Aug 1; 60(10): 3275-3282.
  • Beyond vision loss: the independent impact of diabetic retinopathy on vision-related quality of life in a Chinese Singaporean population Fenwick EK, Man REK, Gan ATL, Kumari N, Wong C, Aravindhan A, Gupta P, Wang JJ, Mitchell P, Wong TY, Cheng CY, Lamoureux EL. Br J Ophthalmol, 2019 Sep; 103(9): 1314-1319.
  • A.Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Arnlov J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gogele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kahonen M, Khor CC, Kiess W, Koenig W, Korner A, Kovacs P, Kramer H, Kramer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimaki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikainen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO, Muller-Nurasyid M, Mychaleckyj JC, Nauck M, Nikus K, Ning B, Noordam R, Connell JO, Olafsson I, Palmer ND, Peters A, Podgornaia AI, Ponte B, Poulain T, Pramstaller PP, Rabelink TJ, Raffield LM, Reilly DF, Rettig R, Rheinberger M, Rice KM, Rivadeneira F, Runz H, Ryan KA, Sabanayagam C, Saum KU, Schottker B, Shaffer CM, Shi Y, Smith AV, Strauch K, Stumvoll M, Sun BB, Szymczak S, Tai ES, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorsteinsdottir U, Tonjes A, Tremblay J, Uitterlinden AG, van der Harst P, Verweij N, Vogelezang S, Volker U, Waldenberger M, Wang C, Wilson OD, Wong C, Wong TY, Yang Q, Yasuda M, Akilesh S, Bochud M, Boger CA, Devuyst O, Edwards TL, Ho K, Morris AP, Parsa A, Pendergrass SA, Psaty BM, Rotter JI, Stefansson K, Wilson JG, Susztak K, Snieder H, Heid IM, Scholz M, Butterworth AS, Hung AM, Pattaro C, Kottgen. Nat Commun, 2019 Sep 11; 10(1): 4130.
  • Additive effect of cerebral atrophy on cognition in dementia-free elderly with cerebrovascular disease Xu X, Phua A, Collinson SL, Hilal S, Ikram MK, Wong TY, Cheng CY, Venketasubramanian N, Chen C. Stroke Vasc Neurol, 2019 Sep; 4(3): 135-140.
  • Associations of autozygosity with a broad range of human phenotypes Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Dorr M, Doumatey AP, Dzimiri N, Ebenesersdottir SS, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Gogele M, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Hofer I, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Kessler T, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Kramer BK, Kutalik Z, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Magi R, Manichaikul AW, Manunta P, Masson G, Matoba N, Mei XW, Meisinger C, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Moreno-Macias H, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, de Mutsert R, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Orozco L, Padmanabhan S, Palsson G, Pankow JS, Pattaro C, Pattie A, Polasek O, Poulter N, Pramstaller PP, Quintana-Murci L, Raikkonen K, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stancakova A, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tusie-Luna T, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Volker U, Vuoksimaa E, Wakil SM, Waldenberger M, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan JM, Zeng L, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Bochud M, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Erdmann J, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Gieger C, Gonzalez C, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hicks AA, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Johansson A, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, Martin NG, Marz W, Matullo G, McCarthy MI, Medland SE, Merriman TR, Metspalu A, Meyer BF, Mohlke KL, Montgomery GW, Mook-Kanamori D, Munroe PB, North KE, Nyholt DR, O’Connell J R, Ober C, Oldehinkel AJ, Palmas W, Palmer C, Pasterkamp GG, Patin E, Pennell CE, Perusse L, Peyser PA, Pirastu M, Polderman TJC, Porteous DJ, Posthuma D, Psaty BM, Rioux JD, Rivadeneira F, Rotimi C, Rotter JI, Rudan I, Den Ruijter HM, Sanghera DK, Sattar N, Schmidt R, Schulze MB, Schunkert H, Scott RA, Shuldiner AR, Sim X, Small N, Smith JA, Sotoodehnia N, Tai ES, Teumer A, Timpson NJ, Toniolo D, Tregouet DA, Tuomi T, Vollenweider P, Wang CA, Weir DR, Whitfield JB, Wijmenga C, Wong TY, Wright J, Yang J, Yu L, Zemel BS, Zonderman AB, Perola M, Magnusson PKE, Uitterlinden AG, Kooner JS, Chasman DI, Loos RJF, Franceschini N, Franke L, Haley CS, Hayward C, Walters RG, Perry JRB, Esko T, Helgason A, Stefansson K, Joshi PK, Kubo M, Wilson JF. Nat Commun, 2019 Oct 31; 10(1): 4957.
  • Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study Dai W, Tham YC, Chee ML, Majithia S, Tan NYQ, Wong KH, Neelam K, Cheung N, Sabanayagam C, Cheung CY, Wong TY, Cheng CY. Br J Ophthalmol, 2019 Oct; 103(10): 1406-1412.
  • VIMCO: variational inference for multiple correlated outcomes in genome-wide association studies Shi X, Jiao Y, Yang Y, Cheng CY, Yang C, Lin X, Liu J. Bioinformatics, 2019 Oct 1; 35(19): 3693-3700.
  • Patterns and Risk Factor Profiles of Visual Loss in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study Wong TY, Tham YC, Sabanayagam C, Cheng CY. Am J Ophthalmol, 2019 Oct; 206: 48-73.
  • Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore Wu D, Dou J, Chai X, Bellis C, Wilm A, Shih CC, Soon WWJ, Bertin N, Lin CB, Khor CC, DeGiorgio M, Cheng S, Bao L, Karnani N, Hwang WYK, Davila S, Tan P, Shabbir A, Moh A, Tan EK, Foo JN, Goh LL, Leong KP, Foo RSY, Lam CSP, Richards AM, Cheng CY, Aung T, Wong TY, Ng HH, Sg K. Consortium, Liu J, Wang C. Cell, 2019 Oct 17; 179(3): 736-749 e715.
  • Association between diabetic retinopathy and incident cognitive impairment Gupta P, Gan ATL, Man REK, Fenwick EK, Sabanayagam C, Mitchell P, Cheung CY, Cheung N, Wong TY, Cheng CY, Lamoureux EL. Br J Ophthalmol, 2019 Nov; 103(11): 1605-1609.
  • Genetic architecture of subcortical brain structures in 38,851 individuals Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, Teumer A, van der Lee SJ, Yang J, Yanek LR, Lee TV, Li S, Hu Y, Koh JY, Eicher JD, Desrivieres S, Arias-Vasquez A, Chauhan G, Athanasiu L, Renteria ME, Kim S, Hoehn D, Armstrong NJ, Chen Q, Holmes AJ, den Braber A, Kloszewska I, Andersson M, Espeseth T, Grimm O, Abramovic L, Alhusaini S, Milaneschi Y, Papmeyer M, Axelsson T, Ehrlich S, Roiz-Santianez R, Kraemer B, Haberg AK, Jones HJ, Pike GB, Stein DJ, Stevens A, Bralten J, Vernooij MW, Harris TB, Filippi I, Witte AV, Guadalupe T, Wittfeld K, Mosley TH, Becker JT, Doan NT, Hagenaars SP, Saba Y, Cuellar-Partida G, Amin N, Hilal S, Nho K, Mirza-Schreiber N, Arfanakis K, Becker DM, Ames D, Goldman AL, Lee PH, Boomsma DI, Lovestone S, Giddaluru S, Le Hellard S, Mattheisen M, Bohlken MM, Kasperaviciute D, Schmaal L, Lawrie SM, Agartz I, Walton E, Tordesillas-Gutierrez D, Davies GE, Shin J, Ipser JC, Vinke LN, Hoogman M, Jia T, Burkhardt R, Klein M, Crivello F, Janowitz D, Carmichael O, Haukvik UK, Aribisala BS, Schmidt H, Strike LT, Cheng CY, Risacher SL, Putz B, Fleischman DA, Assareh AA, Mattay VS, Buckner RL, Mecocci P, Dale AM, Cichon S, Boks MP, Matarin M, Penninx B, Calhoun VD, Chakravarty MM, Marquand AF, Macare C, Kharabian Masouleh S, Oosterlaan J, Amouyel P, Hegenscheid K, Rotter JI, Schork AJ, Liewald DCM, de Zubicaray GI, Wong TY, Shen L, Samann PG, Brodaty H, Roffman JL, de Geus EJC, Tsolaki M, Erk S, van Eijk KR, Cavalleri GL, van der Wee NJA, McIntosh AM, Gollub RL, Bulayeva KB, Bernard M, Richards JS, Himali JJ, Loeffler M, Rommelse N, Hoffmann W, Westlye LT, Valdes Hernandez MC, Hansell NK, van Erp TGM, Wolf C, Kwok JBJ, Vellas B, Heinz A, Olde Loohuis LM, Delanty N, Ho BC, Ching CRK, Shumskaya E, Singh B, Hofman A, van der Meer D, Homuth G, Psaty BM, Bastin ME, Montgomery GW, Foroud TM, Reppermund S, Hottenga JJ, Simmons A, Meyer-Lindenberg A, Cahn W, Whelan CD, van Donkelaar MMJ, Yang Q, Hosten N, Green RC, Thalamuthu A, Mohnke S, Hulshoff Pol HE, Lin H, Jack CR, Jr., Schofield PR, Muhleisen TW, Maillard P, Potkin SG, Wen W, Fletcher E, Toga AW, Gruber O, Huentelman M, Davey Smith G, Launer LJ, Nyberg L, Jonsson EG, Crespo-Facorro B, Koen N, Greve DN, Uitterlinden AG, Weinberger DR, Steen VM, Fedko IO, Groenewold NA, Niessen WJ, Toro R, Tzourio C, Longstreth WT, Jr., Ikram MK, Smoller JW, van Tol MJ, Sussmann JE, Paus T, Lemaitre H, Schroeter ML, Mazoyer B, Andreassen OA, Holsboer F, Depondt C, Veltman DJ, Turner JA, Pausova Z, Schumann G, van Rooij D, Djurovic S, Deary IJ, McMahon KL, Muller-Myhsok B, Brouwer RM, Soininen H, Pandolfo M, Wassink TH, Cheung JW, Wolfers T, Martinot JL, Zwiers MP, Nauck M, Melle I, Martin NG, Kanai R, Westman E, Kahn RS, Sisodiya SM, White T, Saremi A, van Bokhoven H, Brunner HG, Volzke H, Wright MJ, van ‘t Ent D, Nothen MM, Ophoff RA, Buitelaar JK, Fernandez G, Sachdev PS, Rietschel M, van Haren NEM, Fisher SE, Beiser AS, Francks C, Saykin AJ, Mather KA, Romanczuk-Seiferth N, Hartman CA, DeStefano AL, Heslenfeld DJ, Weiner MW, Walter H, Hoekstra PJ, Nyquist PA, Franke B, Bennett DA, Grabe HJ, Johnson AD, Chen C, van Duijn CM, Lopez OL, Fornage M, Wardlaw JM, Schmidt R, DeCarli C, De Jager PL, Villringer A, Debette S, Gudnason V, Medland SE, Shulman JM, Thompson PM, Seshadri S, Ikram MA. Nat Genet, 2019 Nov; 51(11): 1624-1636.
  • Age-related changes of individual macular retinal layers among Asians Chua J, Tham YC, Tan B, Devarajan K, Schwarzhans F, Gan A, Wong D, Cheung CY, Majithia S, Thakur S, Fischer G, Vass C, Cheng CY, Schmetterer L. Sci Rep, 2019 Dec 30; 9(1): 20352.
  • Six-year incidence and progression of diabetic retinopathy in Indian adults: the Singapore Indian Eye study Kumari N, Bhargava M, Nguyen DQ, Gan ATL, Tan G, Cheung N, Tan N, Wong C, Wang JJ, Mitchell P, Lamoureux EL, Cheng CY, Wong TY, Sabanayagam C. Br J Ophthalmol, 2019 Dec; 103(12): 1732-1739.
  • Prevalence, determinants and association of unawareness of diabetes, hypertension and hypercholesterolemia with poor disease control in a multi-ethnic Asian population without cardiovascular disease Man REK, Gan AHW, Fenwick EK, Gan ATL, Gupta P, Sabanayagam C, Tan N, Wong KH, Wong TY, Cheng CY, Lamoureux EL. Popul Health Metr, 2019a Dec 5; 17(1): 17.
  • Is Myopia Associated with the Incidence and Progression of Diabetic Retinopathy? Man REK, Gan ATL, Gupta P, Fenwick EK, Sabanayagam C, Tan NYQ, Mitchell P, Wong TY, Cheng CY, Lamoureux EL. Am J Ophthalmol, 2019b Dec; 208: 226-233.
  • Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma Nongpiur ME, Khor CC, Cheng CY, Husain R, Boey PY, Chew A, Ho CL, Wong TT, Perera S, Wong TY, Vithana EN, Aung T. Am J Ophthalmol, 2019 Dec; 208: 160-165.
  • Multi-trait genome-wide association study identifies new loci associated with optic disc parameters Bonnemaijer PWM, Leeuwen EMV, Iglesias AI, Gharahkhani P, Vitart V, Khawaja AP, Simcoe M, Hohn R, Cree AJ, Igo RP, International Glaucoma Genetics Consortium, Neighborhood Consortium, U.K. Biobank Eye Vision Consortium, Gerhold-Ay A, Nickels S, Wilson JF, Hayward C, Boutin TS, Polasek O, Aung T, Khor CC, Amin N, Lotery AJ, Wiggs JL, Cheng CY, Hysi PG, Hammond CJ, Thiadens A, MacGregor S, Klaver CCW, Duijn CMV. Commun Biol, 2019; 2: 435.
  • Cerebral Small Vessel Disease and Enlarged Perivascular Spaces-Data From Memory Clinic and Population-Based Settings Gyanwali B, Vrooman H, Venketasubramanian N, Wong TY, Cheng CY, Chen C, Hilal S. Front Neurol, 2019; 10: 669.
  • Simplified end stage renal failure risk prediction model for the low-risk general population with chronic kidney disease Lim CC, Chee ML, Cheng CY, Kwek JL, Foo M, Wong TY, Sabanayagam C. PLoS One, 2019; 14(2): e0212590.
  • Deep learning in estimating prevalence and systemic risk factors for diabetic retinopathy: a multi-ethnic study Ting DSW, Cheung CY, Nguyen Q, Sabanayagam C, Lim G, Lim ZW, Tan GSW, Soh YQ, Schmetterer L, Wang YX, Jonas JB, Varma R, Lee ML, Hsu W, Lamoureux E, Cheng CY, Wong TY. NPJ Digit Med, 2019; 2: 24.
  • A genome-wide association study identifies genetic loci associated with specific lobar brain volumes van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, Arfanakis K, Bernard M, Yanek LR, Amin N, Crivello F, Cheung JW, Harris TB, Saba Y, Lopez OL, Li S, van der Grond J, Yu L, Paus T, Roshchupkin GV, Amouyel P, Jahanshad N, Taylor KD, Yang Q, Mathias RA, Boehringer S, Mazoyer B, Rice K, Cheng CY, Maillard P, van Heemst D, Wong TY, Niessen WJ, Beiser AS, Beekman M, Zhao W, Nyquist PA, Chen C, Launer LJ, Psaty BM, Ikram MK, Vernooij MW, Schmidt H, Pausova Z, Becker DM, De Jager PL, Thompson PM, van Duijn CM, Bennett DA, Slagboom PE, Schmidt R, Longstreth WT, Ikram MA, Seshadri S, Debette S, Gudnason V, Adams HHH, DeCarli C. Commun Biol, 2019; 2: 285.
  • Prevalence and Risk Factors for Cognitive Impairment and Dementia in Indians: A Multiethnic Perspective from a Singaporean Study Wong MYZ, Tan CS, Venketasubramanian N, Chen C, Ikram MK, Cheng CY, Hilal S. J Alzheimers Dis, 2019a; 71(1): 341-351.
  • Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium Wong YL, Hysi P, Cheung G, Tedja M, Hoang QV, Tompson SWJ, Whisenhunt KN, Verhoeven V, Zhao W, Hess M, Wong CW, Kifley A, Hosoda Y, Haarman AEG, Hopf S, Laspas P, Sensaki S, Sim X, Miyake M, Tsujikawa A, Lamoureux E, Ohno-Matsui K, Nickels S, Mitchell P, Wong TY, Wang JJ, Hammond CJ, Barathi VA, Cheng CY, Yamashiro K, Young TL, Klaver CCW, Saw SM, Consortium of Refractive Error Myopia. PLoS One, 2019b; 14(8): e0220143.

2018

  • Social, health and ocular factors associated with primary open-angle glaucoma amongst Chinese Singaporeans Chiam N, Baskaran M, Li Z, Perera S, Goh D, Husain R, Khor CC, Cheng CY, Aung T, Vithana EN. Clin Exp Ophthalmol. 2018 Jan;46(1):25-34. doi: 10.1111/ceo.13008. Epub 2017 Aug 9
  • The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study Tan NYQ, Tham YC, Koh V, Nguyen DQ, Cheung CY, Aung T, Wong TY, Cheng CY. Ophthalmology. 2018 Jan;125(1):15-21. doi: 10.1016/j.ophtha.2017.08.002. Epub 2017 Aug 30
  • Factors that influence tear meniscus area and conjunctivochalasis: The Singapore Indian eye study Poh S, Lee R, Gao J, Tan C, Gupta P, Sabanayagam C, Cheng CY, Wong TY, Tong L. Ophthalmic Epidemiol. 2018 Feb;25(1):70-78. doi: 10.1080/09286586.2017.1351999. Epub 2017 Sep 14
  • Caregiver-Reported Sleep Disturbances Are Associated With Behavioral and Psychological Symptoms in an Asian Elderly Cohort With Cognitive Impairment-No Dementia Xu X, Kan CN, Wong TY, Cheng CY, Ikram MK, Chen CL, Venketasubramanian N. J Geriatr Psychiatry Neurol. 2018 Mar;31(2):70-75. doi: 10.1177/0891988718758203. Epub 2018 Mar 19
  • CCDC102B confers risk of low vision and blindness in high myopia Hosoda Y, Yoshikawa M, Miyake M, Tabara Y, Shimada N, Zhao W, Oishi A, Nakanishi H, Hata M, Akagi T, Ooto S, Nagaoka N, Fang Y; Nagahama Study group; Ohno-Matsui K, Cheng CY, Saw SM, Yamada R, Matsuda F, Tsujikawa A, Yamashiro K. Nat Commun. 2018 May 3;9(1):1782. doi: 10.1038/s41467-018-03649-3
  • Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study. Dai W, Tham YC, Cheung N, Yasuda M, Tan NYQ, Cheung CY, Wang JJ, Mitchell P, Sabanayagam C, Wong TY, Cheng CY.Br J Ophthalmol. 2018 Aug;102(8):1072-1076. doi: 10.1136/bjophthalmol-2017-310959. Epub 2017 Nov 24
  • Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements Cheung CMG, Shi Y, Tham YC, Sabanayagam C, Neelam K, Wang JJ, Mitchell P, Cheng CY, Wong TY, Cheung CYL. Sci Rep. 2018 Aug 28;8(1):12937. doi: 10.1038/s41598-018-31109-x
  • Trends of Visual Impairment and Blindness in the Singapore Chinese Population over a Decade Tham YC, Lim SH, Shi Y, Chee ML, Zheng YF, Chua J, Saw SM, Foster P, Aung T, Wong TY, Cheng CY. Sci Rep. 2018 Aug 15;8(1):12224. doi: 10.1038/s41598-018-30004-9
  • Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract Tan AG, Kifley A, Holliday EG, Klein BEK, Iyengar SK, Lee KE, Jun GR, Cumming RG, Zhao W, Wong TY, Cheng CY, Mitchell P, Wang JJ. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4755-4762. doi: 10.1167/iovs.18-24353
  • Prevalence, Risk Factors, and Impact of Myopic Macular Degeneration on Visual Impairment and Functioning Among Adults in Singapore Wong YL, Sabanayagam C, Ding Y, Wong CW, Yeo AC, Cheung YB, Cheung G, Chia A, Ohno-Matsui K, Wong TY, Wang JJ, Cheng CY, Hoang QV, Lamoureux E, Saw SM. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4603-4613. doi: 10.1167/iovs.18-24032
  • Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study Gupta P, Gan ATL, Man REK, Fenwick EK, Tham YC, Sabanayagam C, Wong TY, Cheng CY, Lamoureux EL. Sci Rep. 2018 Oct 4;8(1):14805. doi: 10.1038/s41598-018-32833-0
  • Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study Tan B, Venketasubramanian N, Vrooman H, Cheng CY, Wong TY, Chen C, Hilal S. Alzheimers Res Ther. 2018 Nov 6;10(1):114. doi: 10.1186/s13195-018-0440-5
  • An Automated Grading System for Detection of Vision-Threatening Referable Diabetic Retinopathy on the Basis of Color Fundus Photographs Li Z, Keel S, Liu C, He Y, Meng W, Scheetz J, Lee PY, Shaw J, Ting D, Wong TY, Taylor H, Chang R, He M. Diabetes Care. 2018 Dec;41(12):2509-2516. doi: 10.2337/dc18-0147. Epub 2018 Oct 1
  • Six-Year Incidence of and Risk Factors for Cataract Surgery in a Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study Tan AG, Kifley A, Tham YC, Shi Y, Chee ML, Sabanayagam C, Tan NYQ, Wong KH, Mitchell P, Cumming RG, Wong TY, Wang JJ, Cheng CY. Ophthalmology. 2018 Dec;125(12):1844-1853. doi: 10.1016/j.ophtha.2018.07.026. Epub 2018 Aug 2
  • Human pharyngeal microbiota in age-related macular degeneration Ho EXP, Cheung CMG, Sim S, Chu CW, Wilm A, Lin CB, Mathur R, Wong D, Chan CM, Bhagarva M, Laude A, Lim TH, Wong TY, Cheng CY, Davila S, Hibberd M. PLoS One. 2018 Aug 8;13(8):e0201768. doi: 10.1371/journal.pone.0201768
  • Diagnostic accuracy of macular ganglion cell-inner plexiform layer thickness for glaucoma detection in a population-based study: Comparison with optic nerve head imaging parameters Koh V, Tham YC, Cheung CY, Mani B, Wong TY, Aung T, Cheng CY. PLoS One. 2018 Jun 26;13(6):e0199134. doi: 10.1371/journal.pone.0199134
  • Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study Tan B, Venketasubramanian N, Vrooman H, Cheng CY, Wong TY, Ikram MK, Chen C, Hilal S. J Alzheimers Dis. 2018;62(2):877-885. doi: 10.3233/JAD-170796
  • Sleep Duration and Diabetic Kidney Disease Tan NYQ, Chan J, Cheng CY, Wong TY, Sabanayagam C. Front Endocrinol (Lausanne). 2019 Jan 14;9:808. doi: 10.3389/fendo.2018.00808
  • A genome-wide association study of corneal astigmatism: The CREAM Consortium Shah RL, Li Q, Zhao W, Tedja MS, Tideman JWL, Khawaja AP, Fan Q, Yazar S, Williams KM, Verhoeven VJM, Xie J, Wang YX, Hess M, Nickels S, Lackner KJ, Pärssinen O, Wedenoja J, Biino G, Concas MP, Uitterlinden A, Rivadeneira F, Jaddoe VWV, Hysi PG, Sim X, Tan N, Tham YC, Sensaki S, Hofman A, Vingerling JR, Jonas JB, Mitchell P, Hammond CJ, Höhn R, Baird PN, Wong TY, Cheng CY, Teo YY, Mackey DA, Williams C, Saw SM, Klaver CCW, Guggenheim JA, Bailey-Wilson JE; CREAM Consortium. Mol Vis. 2018 Feb 5;24:127-142
  • Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yamashiro K; Japan Glaucoma Society Omics Group (JGS-OG); Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Aihara M, Araie M, Yamamoto T, Kiuchi Y, Nakamura M, Ikeda Y, Sonoda KH, Ishibashi T, Nitta K, Iwase A, Shirato S, Oka Y, Satoh M, Sasaki M, Fuse N, Suzuki Y, Cheng CY, Khor CC, Baskaran M, Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH, Pasquale LR, Haines JL; NEIGHBORHOOD Consortium; Wiggs JL, Burdon KP, Gharahkhani P, Hewitt AW, Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A, Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T, Kubo M. Hum Mol Genet. 2018 Apr 15;27(8):1486-1496. doi: 10.1093/hmg/ddy053
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Höhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P, Bailey JNC, Willoughby CE, Li X, Yazar S, Nag A, Khawaja AP, Polašek O, Siscovick D, Mitchell P, Tham YC, Haines JL, Kearns LS, Hayward C, Shi Y, van Leeuwen EM, Taylor KD; Blue Mountains Eye Study—GWAS group; Bonnemaijer P, Rotter JI, Martin NG, Zeller T, Mills RA, Souzeau E, Staffieri SE, Jonas JB, Schmidtmann I, Boutin T, Kang JH, Lucas SEM, Wong TY, Beutel ME, Wilson JF; NEIGHBORHOOD Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2); Uitterlinden AG, Vithana EN, Foster PJ, Hysi PG, Hewitt AW, Khor CC, Pasquale LR, Montgomery GW, Klaver CCW, Aung T, Pfeiffer N, Mackey DA, Hammond CJ, Cheng CY, Craig JE, Rabinowitz YS, Wiggs JL, Burdon KP, van Duijn CM, MacGregor S. Nat Commun. 2018 May 14;9(1):1864. doi: 10.1038/s41467-018-03646-6. Erratum in: Nat Commun. 2019 Jan 8;10(1):155
  • Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error  Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY, Höhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Polašek O, Hayward C, Bencic G, Rudan I, Wilson JF; CREAM Consortium; 23andMe Research Team; UK Biobank Eye and Vision Consortium; Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimäki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP Jr, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Pärssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW. Nat Genet. 2018 Jun;50(6):834-848. doi: 10.1038/s41588-018-0127-7. Epub 2018 May 28
  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, Moon S, Spracklen CN, Chai JF, Kim YJ, Zhang L, Wang C, Li H, Li H, Wu JY, Dorajoo R, Nierenberg JL, Wang YX, He J, Bennett DA, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Rakugi H, Nakashima E, Isono M, Shirota M, Hozawa A, Ichihara S, Matsubara T, Yamamoto K, Kohara K, Igase M, Han S, Gordon-Larsen P, Huang W, Lee NR, Adair LS, Hwang MY, Lee J, Chee ML, Sabanayagam C, Zhao W, Liu J, Reilly DF, Sun L, Huo S, Edwards TL, Long J, Chang LC, Chen CH, Yuan JM, Koh WP, Friedlander Y, Kelly TN, Bin Wei W, Xu L, Cai H, Xiang YB, Lin K, Clarke R, Walters RG, Millwood IY, Li L, Chambers JC, Kooner JS, Elliott P, van der Harst P; International Genomics of Blood Pressure (iGEN-BP) Consortium; Chen Z, Sasaki M, Shu XO, Jonas JB, He J, Heng CK, Chen YT, Zheng W, Lin X, Teo YY, Tai ES, Cheng CY, Wong TY, Sim X, Mohlke KL, Yamamoto M, Kim BJ, Miki T, Nabika T, Yokota M, Kamatani Y, Kubo M, Kato N. Nat Commun. 2018 Nov 28;9(1):5052. doi: 10.1038/s41467-018-07345-0
  • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP, Horimoto ARVR, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Wojczynski MK, Alver M, Boissel M, Cai Q, Campbell A, Chai JF, Chen X, Divers J, Gao C, Goel A, Hagemeijer Y, Harris SE, He M, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Komulainen P, Kühnel B, Laguzzi F, Luan J, Matoba N, Nolte IM, Padmanabhan S, Riaz M, Rueedi R, Robino A, Said MA, Scott RA, Sofer T, Stančáková A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Vitart V, Wang Y, Ware EB, Warren HR, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Boerwinkle E, Borecki I, Broeckel U, Brown M, Brumat M, Burke GL, Canouil M, Chakravarti A, Charumathi S, Ida Chen YD, Connell JM, Correa A, de Las Fuentes L, de Mutsert R, de Silva HJ, Deng X, Ding J, Duan Q, Eaton CB, Ehret G, Eppinga RN, Evangelou E, Faul JD, Felix SB, Forouhi NG, Forrester T, Franco OH, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gigante B, Gu CC, Gu D, Hagenaars SP, Hallmans G, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Howard BV, Ikram MA; InterAct Consortium; John U, Katsuya T, Khor CC, Kilpeläinen TO, Koh WP, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lin S, Liu J, Liu J, Loh M, Louie T, Mägi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Nalls MA, Nelson CP, Sotoodehnia N, Norris JM, O’Connell JR, Palmer ND, Perls T, Pedersen NL, Peters A, Peyser PA, Poulter N, Raffel LJ, Raitakari OT, Roll K, Rose LM, Rosendaal FR, Rotter JI, Schmidt CO, Schreiner PJ, Schupf N, Scott WR, Sever PS, Shi Y, Sidney S, Sims M, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Turner ST, Uitterlinden AG, Vollenweider P, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Yao J, Yu C, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kamatani Y, Kato N, Kooner JS, Kutalik Z, Laakso M, Laurie CC, Leander K, Lehtimäki T, Study LC, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Polasek O, Porteous DJ, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Bouchard C, Christensen K, Evans MK, Gudnason V, Horta BL, Kardia SLR, Liu Y, Pereira AC, Psaty BM, Ridker PM, van Dam RM, Gauderman WJ, Zhu X, Mook-Kanamori DO, Fornage M, Rotimi CN, Cupples LA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Kooperberg C, Palmas W, Rice K, Morrison AC, Elliott P, Caulfield MJ, Munroe PB, Rao DC, Province MA, Levy D. PLoS One. 2018 Jun 18;13(6):e0198166. doi: 10.1371/journal.pone.0198166
  • A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, ‘an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A; CHARGE Neurology Working Group; Chauhan G, Christensen K, Cocca M; COGENT-Kidney Consortium; Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H; GIANT Consortium; Gigante B, Graff M, Gu CC, Gu D, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y; Lifelines Cohort Study; Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH Jr, Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O’Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI. Am J Hum Genet. 2018 Mar 1;102(3):375-400. doi: 10.1016/j.ajhg.2018.01.015. Epub 2018 Feb 15
  • Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease Nongpiur ME, Cheng CY, Duvesh R, Vijayan S, Baskaran M, Khor CC, Allen J, Kavitha S, Venkatesh R, Goh D, Husain R, Boey PY, Quek D, Ho CL, Wong TT, Perera S, Wong TY, Krishnadas SR, Sundaresan P, Aung T, Vithana EN.Ophthalmology. 2018 May;125(5):664-670. doi: 10.1016/j.ophtha.2017.11.016. Epub 2018 Jan 6
  • Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study Tham YC, Lim SH, Gupta P, Aung T, Wong TY, Cheng CYBr J Ophthalmol. 2018 Oct;102(10):1402-1406. doi: 10.1136/bjophthalmol-2017-311359. Epub 2018 Jan 13
  • Diabetic Retinopathy in the Asia-Pacific Chua J, Lim CXY, Wong TY, Sabanayagam CAsia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):3-16. doi: 10.22608/APO.2017511. Epub 2017
  • Prevalence, subtypes, severity and determinants of ocular trauma: The Singapore Chinese Eye Study Wong MY, Man RE, Gupta P, Sabanayagam C, Wong TY, Cheng CY, Lamoureux EL.Br J Ophthalmol. 2018 Feb;102(2):204-209. doi: 10.1136/bjophthalmol-2017-310564. Epub 2017 Jun 16
  • Factors affecting signal strength in spectral-domain optical coherence tomography Lee R, Tham YC, Cheung CY, Sidhartha E, Siantar RG, Lim SH, Wong TY, Cheng CY.Acta Ophthalmol. 2018 Feb;96(1):e54-e58. doi: 10.1111/aos.13443. Epub 2017 Apr 9.
  • Differential effect of body mass index on the incidence of diabetes and diabetic retinopathy in two Asian populations Chan JCY, Chee ML, Tan NYQ, Cheng CY, Wong TY, Sabanayagam CNutr Diabetes. 2018 Mar 7;8(1):16. doi: 10.1038/s41387-018-0018-0.
  • Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning Gupta P, Liang Gan AT, Kidd Man RE, Fenwick EK, Kumari N, Tan G, Mitchell P, Sabanayagam C, Wong TY, Cheng CY, Lamoureux ELSend toOphthalmology. 2018 Sep;125(9):1401-1409. doi: 10.1016/j.ophtha.2018.02.011. Epub 2018 Mar 20
  • Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study. Luo XY, Tan NYQ, Chee ML, Shi Y, Tham YC, Wong TY, Wang JJ, Cheng CYInvest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2205-2211. doi: 10.1167/iovs.17-23013.
  • Ethnic Differences in the Prevalence and Risk Factors of Diabetic Retinopathy: The Singapore Epidemiology of Eye Diseases Study Tan GS, Gan A, Sabanayagam C, Tham YC, Neelam K, Mitchell P, Wang JJ, Lamoureux EL, Cheng CY, Wong TY.Ophthalmology. 2018 Apr;125(4):529-536. doi: 10.1016/j.ophtha.2017.10.026. Epub 2017 Dec 6.
  • Falls and Recurrent Falls among Adults in A Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study Dai W, Tham YC, Chee ML, Tan NYQ, Wong KH, Majithia S, Sabanayagam C, Lamoureux E, Wong TY, Cheng CYSci Rep. 2018 May 15;8(1):7575. doi: 10.1038/s41598-018-25894-8.
  • Choroidal Nevi in the Singapore Epidemiology of Eye Disease Study. Ng SR, Zhao W, Mitchell P, Wang JJ, Foo HXV, Neelam K, Cheng CY, Wong TY, Cheung NOphthalmology. 2018 May;125(5):784-786. doi: 10.1016/j.ophtha.2017.12.019. Epub 2018 Feb 1.
  • Associations between sleep duration, sleep quality and diabetic retinopathy. Tan NYQ, Chew M, Tham YC, Nguyen QD, Yasuda M, Cheng CY, Wong TY, Sabanayagam CPLoS One. 2018 May 24;13(5):e0196399. doi: 10.1371/journal.pone.0196399. eCollection 2018.
  • Associations of Peripapillary Atrophy and Fundus Tessellation with Diabetic Retinopathy. Nicholas Y.Q. Tan, Yih-Chung Tham,, Yang Ding, Masayuki Yasuda, Charumathi Sabanayagam, Seang-Mei Saw, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu ChengOphthalmology Retina, Volume 2 , Issue 6 , 574 – 581
  • Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean Indians: The Singapore Indian Eye Study.Foo VHX, Yanagi Y, Nguyen QD, Sabanayagam C, Lim SH, Neelam K, Wang JJ, Mitchell P, Cheng CY, Wong TY, Cheung CMGSci Rep. 2018 Jun 11;8(1):8869

 

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Cornea & refractive
Glaucoma, angle closure glaucoma
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