Drug Delivery System

Over the years, we have looked at drug delivery as a three step process: The first step involves designing suitable drug carriers from nanoparticles to microbubbles. We have fabricated these vehicles using various methods such as electrohydrodynamic atomization (EHDA), supercritical fluid technology, and nanoprecipitation. Followed by developing tumour models using patient MRI data to study the distribution of the encapsulated drug and the diffusion of drug through the solid tumour. Finally, evaluation of the therapeutic efficacy of the fabricated system in in-vitro cell culture systems and animal models. In recent years, we have explored the application of 3D printing for the fabrication of biomimetic human skin, which has potential applications in wound healing, drug screening and cosmetics testing. Bioprinting commonly involves three steps: pre-processing, processing and post-processing. Besides the processing step, we have investigated the post-processing aspect as well, whereby we have investigated the use of bioreactor systems for the maturation of bioprinted dermal tissue after printing. Furthermore, we have explored the use of 3D printing in the fabrication of wound dressings, which can potentially complement existing burn wound treatment regimens.