How do lymphoid disorders manifest clinically?
- Lymphadenopathy
- Inflammatory symptoms / signs
- Systemic symptoms / signs
Mindmap: Main clinical manifestations of lymphoid diseases.
Clinicopathologic Correlates:
What are some questions to ask in a patient with lymphadenopathy?
- Nature of lymphadenopathy - Localised vs generalised?
- Local signs/symptoms of inflammation – Pain, tenderness, redness, warmth
- Systemic symptoms – fever, malaise, night sweats (associated with TB and some lymphomas)
- Any regional pathology is draining sites – ulcers, masses, eczem
- Past history and Systems review
- Past history – immunocompromised state (predispose to lymphoma), known malignancy?
- Systems review – history of known malignancy presenting with metastatic nodal disease
More information on a practical approach will be covered in the Approach to Lymphadenotpathy Mindmap below.
Let’s think about the PATIENT:
Mindmap: Approach to Lymphadenopathy