Project Title: Impact of variation in food intakes, physical activity, and psychological stress on fluctuations in 24-hr plasma glucose levels 

Background

The prevalence of type 2 diabetes is increasing worldwide. Large fluctuations in blood glucose concentrations during the day appear to be detrimental for weight gain and risk of type 2 diabetes. Insights into the lifestyle determinants of fluctuations in glucose concentrations are needed to identify targets for interventions. Thus far, few studies have been conducted to understand determinants of fluctuations in blood glucose concentrations throughout the day.

The aims of the study are:

1. To elucidate how within-person variation in food intake, physical activity and psychological stress affect fluctuations in blood glucose concentrations.
2. To describe to what extent the response of individuals to a standardized meal tolerance test can predict real-life variation in blood glucose concentrations. This will provide insight into the relative importance of variation in dietary and other lifestyle behaviours and an individual’s predisposition to higher blood glucose responses.
3. To assess whether research collecting multiple repeated measures of food intake, activity, and stress is feasible in epidemiological studies.

Presentation/Publication

• Park SH, Yao J, Chua XH, Chandran SR, Gardner DSL, Khoo CM, Müller-Riemenschneider F, Whitton C, van Dam RM. Diet and Physical Activity as Determinants of Continuously Measured Glucose Levels in Persons at High Risk of Type 2 Diabetes. Nutrients. 2022 Jan 15;14(2):366. doi: 10.3390/nu14020366.

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Last updated Apr 21, 2023