T2D (Nat Genet 2011)

We carried out GWAS meta-analysis (imputed to HapMap2) for T2D in up to 25,079 East Asians cases and 29,611 controls. Each study performed study-specific sample and variant quality control. Within each study, associations between T2D and variants were tested by logistic regression, adjusting for sex. We then carried out fixed-effects inverse-variance weighted meta-analysis as implemented in METAL. 

The files below contain association summary statistics for the AGEN lipids meta-analysis of 7 discovery studies (KARE, DC-SP2 with 2 arrays, SiMES, CAGE, SDGS, TDS, CLHNS).

Each file contains the following information:

  2. CHR: Chromosome
  3. POS: Position (hg19)
  4. EFF_ALLELE: Effect allele
  5. NONEFF_ALLELE: Other allele
  6. EFF_ALLELE_FREQ: Effect allele frequency (1000G Phase 3 EAS)
  7. BETA: Effect estimate
  8. SEBETA: Standard error of effect estimate
  9. P: P-value


Reference: Cho YS, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67-72. doi: 10.1038/ng.1019. PubMed PMID: 22158537; PubMed Central PMCID: PMC3582398.

Please refer any queries to Dr Xueling Sim (ephsx@nus.edu.sg)