We carried out GWAS meta-analysis (imputed to HapMap2) for HDL-C, LDL-C, TC, and TG in up to 34,421 East Asians. Each study performed study-specific sample and variant quality control. Within each study, residuals of lipid traits were computed by including age, sex, BMI, and other study-specific covariates in a linear regression model. Inverse normalised residuals were used to test genotype-phenotype relationship with variants under an additive model. We then carried out fixed-effects sample-size weighted meta-analysis as implemented in METAL.
The files below contain association summary statistics for the AGEN lipids meta-analysis of 13 studies (CAGE-Network, CLHNS, GenSalt, KARE, KCPS II, SBCS, SCES, SiMES, SP2, SWMHS, TWSC, BES, CHNS).
Each file contains the following information:
- CHR: chromosome
- POS: position (hg19)
- MARKERNAME: RSID
- N: Total sample size
- EFF_ALLELE: Effect allele
- NONEFF_ALLELE: Other allele
- EFF_ALLELE_FREQ: Effect allele frequency
- BETA: Effect estimate
- SEBETA: Standard error of effect estimate
- P: P-value
Reference: Spracklen CN, et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017 May 1;26(9):1770-1784. doi: 10.1093/hmg/ddx062. Erratum in: Hum Mol Genet. 2018 Mar 15;27(6):1122. PubMed PMID: 28334899; PubMed Central PMCID: PMC6075203.
Please refer any queries to Dr Xueling Sim (firstname.lastname@example.org)