We carried out GWAS meta-analysis (imputed to HapMap2) for adiponectin levels in up to 7,825 East Asians. Each study performed study-specific sample and variant quality control. Within each study, residuals of lipid traits were computed by including age, sex, BMI, and other study-specific covariates in a linear regression model. Inverse normalized residuals were used to test genotype-phenotype relationships with variants under the additive model. We then carried out fixed-effects sample-size weighted meta-analysis as implemented in METAL.
The file contains association summary statistics for the AGEN meta-analysis of 4 studies (CLHNS, KCPS-II, NHAPC, and SP2).
Each file contains the following information:
- CHR: chromosome
- POS: position (hg19)
- MARKERNAME: RSID
- N: Total sample size
- EFF_ALLELE: Effect allele
- NONEFF_ALLELE: Other allele
- EFF_ALLELE_FREQ: Effect allele frequency
- BETA: Effect estimate (gc-corrected)
- SEBETA: Standard error of effect estimate (gc-corrected)
- P: P-value (gc-corrected)
Reference: Wu Y, et al. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Hum Mol Genet 2014;23(4):1108-1119. PMID: 24105470
Please refer any queries to Professor Karen Mohlke (karen_mohlke@med.unc.edu)