What is the difference between domperidone and metoclopramide? Why is domperidone not always preferred, as it has less risk of CNS adverse effects?
Gastrointestinal motility disorders and nausea are common clinical challenges, and two dopamine antagonists — domperidone and metoclopramide — are often used in their management. Although both act on dopamine D2 receptors, key differences in their pharmacokinetics, central nervous system penetration, and adverse effect profiles make the choice between them more than a matter of availability. Let’s unpack the differences.