It is important to learn about the rare, serious adverse effects of over-the-counter (OTC) medications. Pseudoephedrine, a commonly used decongestant, is one such drug that can have unexpected neurological consequences.
Recent updates in adverse event reports have highlighted the rare but important risks of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) associated with pseudoephedrine. Understanding these risks is crucial.
Pseudoephedrine: A Common but Potent OTC Drug
Pseudoephedrine is a sympathomimetic agent that acts by vasoconstricting the blood vessels in the nasal passages, which helps relieve nasal congestion. It is often included in many combination medications for treating the common cold, allergies, and sinus congestion. Pseudoephedrine-containing products have been marketed in Singapore since the 1980s, and no significant safety issues were reported locally until recently. However, overseas cases of rare neurological syndromes linked to pseudoephedrine have been documented, prompting regulatory agencies to enhance warnings and recommendations.