Click here for a comprehensive list of our publications in PubMed

2011

Lai MK, Tsang SW, Esiri MM, Francis PT, Wong PT, Chen CP. Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer’s disease.

 

Mohamed NE, Zhao Y, Lee JH, Tan MG, Esiri MM, Wilcock GK, Smith AD, Wong PT, Chen CP, Lai MK. Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer’s disease.

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2010

Aisa B, Gil-Bea FJ, Solas M, García-Alloza M, Chen CP, Lai MK, Francis PT, Ramírez MJ. Altered NCAM expression associated with the cholinergic system in Alzheimer’s disease.

 

Francis PT, Ramírez MJ, Lai MK. Neurochemical basis for symptomatic treatment of Alzheimer’s disease.

 

Tan MG, Chua WT, Esiri MM, Smith AD, Vinters HV, Lai MK. Genome wide profiling of altered gene expression in the neocortex of Alzheimer’s disease.

 

Tsang SW, Keene J, Hope T, Spence I, Francis PT, Wong PT, Chen CP, Lai MK. A serotoninergic basis for hyperphagic eating changes in Alzheimer’s disease.

 

Lee JH, Agacinski G, Williams JH, Wilcock GK, Esiri MM, Francis PT, Wong PT, Chen CP, Lai MK. Intact cannabinoid CB1 receptors in the Alzheimer’s disease cortex.

 

Lai MK, Chen CP, Hope T, Esiri MM. Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia.

 

Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S. Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.

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2009

Medhurst AD, Roberts JC, Lee J, Chen CP, Brown SH, Roman S, Lai MK. Characterization of histamine H3 receptors in Alzheimer’s Disease brain and amyloid over-expressing TASTPM mice.

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2008

Marcos B, García-Alloza M, Gil-Bea FJ, Chuang TT, Francis PT, Chen CP, Tsang SW, Lai MK, Ramirez MJ. Involvement of an altered 5-HT6 receptor function in behavioral symptoms of Alzheimer’s disease.

 

Lai MK, Tan MG, Kirvell S, Hobbs C, Lee J, Esiri MM, Chen CP, Francis PT. Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer’s disease neuropathology.

 

Tsang SW, Francis PT, Esiri MM, Wong PT, Chen CP, Lai MK. Loss of [³H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer’s disease patients with psychosis.

 

Tsang SW, Vinters HV, Cummings JL, Wong PT, Chen CP, Lai MK. Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer’s disease.

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2007

Tsang SW, Pomakian J, Marshall GA, Vinters HV, Cummings JL, Chen CP, Wong PT, Lai MK. Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer’s disease.

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2006

Lai MK, Tsang SW, Garcia-Alloza M, Minger SL, Nicoll JA, Esiri MM, Wong PT, Chen CP, Ramírez MJ, Francis PT. Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer’s disease.

 

Tsang SW, Lai MK, Kirvell S, Francis PT, Esiri MM, Hope T, Chen CP, Wong PT. Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer’s disease.

 

Garcia-Alloza M, Tsang SW, Gil-Bea FJ, Francis PT, Lai MK, Marcos B, Chen CP, Ramirez MJ. Involvement of the GABAergic system in depressive symptoms of Alzheimer’s disease.

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2005

 

 

 

Lai MK, Tsang SW, Alder JT, Keene J, Hope T, Esiri MM, Francis PT, Chen CP. Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer’s disease.

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2003

Lai MK, Tsang SW, Francis PT, Esiri MM, Keene J, Hope T, Chen CP. Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease.

 

 

 

 

Lai MK, Tsang SW, Francis PT, Esiri MM, Hope T, Lai OF, Spence I, Chen CP. [³H] GR113808 binding to serotonin 5-HT4 receptors in the postmortem neocortex of Alzheimer disease: a clinicopathological study.

 

Tsang SW, Lai MK, Francis PT, Wong PT, Spence I, Esiri MM, Keene J, Hope T, Chen CP. Serotonin transporters are preserved in the neocortex of anxious Alzheimer’s disease patients.

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2002

Lai MK, Tsang SW, Francis PT, Keene J, Hope T, Esiri MM, Spence I, Chen CP. Postmortem serotoninergic correlates of cognitive decline in Alzheimer’s disease.

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2001

Lai MK, Lai OF, Keene J, Esiri MM, Francis PT, Hope T, Chen CP. Psychosis of Alzheimer’s disease is associated with elevated muscarinic M2 binding in the cortex.