152. Wan S,Wang K,Huang P,Guo X, Liu W, Li Y, Zhang J, Li Z, Song J, Yang W, Zhang X, Ding X*, Leong DT*, Wang L*. Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation. Nature Communications. 2024, 15, 3343.

151. LX Yip, J Wang, Y Xue, K Xing, C Sevencan, K Ariga, DT Leong*. Cell-derived nanomaterials for biomedical applications. Science and Technology of Advanced Materials 2024, 2315013.

150. Li Y, Ni N, Lee M, Wei W, Andrikopoulos N, Kakinen A, Davis TP, Song Y, Ding F, Leong DT*, Ke PC*.  Endothelial leakiness elicited by amyloid protein aggregation. Nature Communications 2024, 15, 613 .

149. Wang Q, Liang Q, Dou J, Zhou H, Zeng C, Pan H, Shen Y, Li Q, Liu Y, Leong DT*, Jiang W*, Wang Y*. Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours. Nature Nanotechnology 2024, 19, 95-105.



148. MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga, PC Ke, HK Ho, Y Wang*, DT Leong*. Engineering tumoral vascular leakiness with gold nanoparticles. Nature Communications 2023, 14, 4269.

147. Q Liu, D Wu, B He, X Ding, Y Xu, Y Wang, M Zhang, H Qian, DT Leong*, G Wang*. Attenuating endothelial leakiness with self-assembled DNA nanostructures for pulmonary arterial hypertension. Nanoscale Horizons 2023, 8, 270-278.



146. X Shen, J Song, C Sevencan, DT Leong*, K Ariga*. Bio-interactive nanoarchitectonics with two-dimensional materials and environments. Science and Technology of Advanced Materials. 2022, 23, 199-224.

145. H Qian, D Wang, B He, Q Liu, Y Xu, D Wu, C Chen, W Zhang, DT Leong*, G Wang*. Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy. NPG Asia Materials. 2022, 14, 81.

144. BL Li, JJ Luo, HL Zou, QM Zhang, LB Zhao, H Qian, HQ Luo, DT Leong*, NB Li*. Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs. Nature Communications. 2022, 13, 7289 23.

143. N Yan, K Zhou, YW Tong, DT Leong, MP Dickieson. Pathways to food from CO2 via ‘green chemical farming’. Nature Sustainability. 2022, 5, 907-909.

142. R Malhotra, CE Halbig, YF Sim, CT Lim, DT Leong, AHC Neto, S Garaj, V Rosa. Cytotoxicity survey of commercial graphene materials from worldwide. NPG 2D Materials and Applications. 2022, 6, 65.

141. BL Li, H Zhang, NB Li, H Qian, DT Leong. Materialistic interfaces with nucleic acids: principles and their impact. Advanced Functional Materials. 2022, 32, 2201172.

140. W Wei, Y Li, M Lee, N Andrikopoulos, S Lin, C Chen, DT Leong, F Ding, Y Song, PC Ke. Anionic nanoplastic exposure induces endothelial leakiness. Nature Communications. 2022, 13, 4757.

139. N Ni, W Wang, Y Sun, X Sun, DT Leong. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials. 2022, 287, 121640 26 2022

138. H Zhu, W Zan, W Chen, W Jiang, X Ding, BL Li, Y Mu, L Wang, S Garaj, Leong DT*. Defect‐Rich Molybdenum Sulfide Quantum Dots for Amplified Photoluminescence and Photonics‐Driven Reactive Oxygen Species Generation. Advanced Materials. 2022, 34 (31), 2200004 27 2022

137. H Zhu, S Huang, M Ding, Z Li, J Li, S Wang, DT Leong. Sulfur defect-engineered biodegradable cobalt sulfide quantum dot-driven photothermal and chemodynamic anticancer therapy. ACS Applied Materials & Interfaces. 2022, 14, 25183-25196.

136 W Wei, Z Yan, X Liu, Z Qin, X Tao, X Zhu, E Song, C Chen, PC Ke, Leong DT, Song Y. Brain accumulation and toxicity profiles of silica nanoparticles: the influence of size and exposure route. Environmental Science & Technology. 2022, 56, 8319-8325.

135. KYW Teo, C Sevencan, YA Cheow, S Zhang, DT Leong*, WS Toh*. Macrophage Polarization as a Facile Strategy to Enhance Efficacy of Macrophage Membrane‐Coated Nanoparticles in Osteoarthritis. Small Science. 2022, 2, 2100116.

134. C Chen, Q Liu, Y Yuan, X Cai, X Ding, B Li, Y Yang, B Wang, G Wang, DT Leong*, H Qian*. Protein-mediated DNA self-assembly by controlling the surface charge in a molecular crowding environment. Biomaterials Science. 2022, 10, 2006-2013.



133. H Zhu, Z Li, E Ye, DT Leong. Oxygenic enrichment in hybrid ruthenium sulfide nanoclusters for an optimized photothermal effect. ACS applied materials & interfaces 2021, 13, 60351-60361.

132. A Nandakumar, W Wei, G Siddiqui, H Tang, Y Li, A Kakinen, X Wan, K Koppel, S Lin, T P Davis, DT Leong, DJ Creek, F Ding, Y Song, PC Ke. Dynamic protein corona of gold nanoparticles with an evolving morphology. ACS applied materials & interfaces 2021, 13, 58238-58251.

131. M Lee, N Ni, H Tang, Y Li, W Wei, A Kakinen, X Wan, TP Davis, Y Song, DT Leong*, F Ding, PC Ke. A framework of paracellular transport via nanoparticles‐induced endothelial leakiness. Advanced Science 2021, 8, 2102519.

130. X Shao, Z Ding, W Zhou, Y Li, Z Li, H Cui, X Lin, G Cao, B Cheng, H Sun,  M Li, K Liu, D Lu, S Geng, W Shi, G Zhang, Q Song, L Chen, G Wang, W Su, L Cai, L Fang, DT Leong, Y Li, X-F Yu, H Li. Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. Nature Nanotechnology 2021, 16, 1150-1160.

129. D Wang, C Chen, Q Liu, Q Zhao, D Wu, Y Yuan, C Huang, X Sun, C Huang, DT Leong*, G Wang*, H Qian*. Functionalizing DNA nanostructures with natural cationic amino acids. Bioactive Materials 2021, 6, 2946-2955

128. X Xia, B Shi, L Wang, Y Liu, Y Zou, Y Zhou, Y Chen, M Zheng, Y Zhu, J Duan, S Guo, HW Jang, Y Miao, K Fan, F Bai, W Tao, Y Zhao, Q Yan, G Cheng, H Liu, Y Jiao, S Liu, Y Huang, D Ling, W Kang, X Xue, D Cui, Y Huang, Z Cui, X Sun, Z Qian, Z Gu, G Han, Z Yang, DT Leong, A Wu, G Liu, X Qu, Y Shen, Q Wang, GV Lowry, E Wang, X‐J Liang, J Gardea‐Torresdey, G Chen, WJ Parak, PS Weiss, L Zhang, MM Stenzel, C Fan, AI Bush, G Zhang, CPL Grof, X Wang, DW Galbraith, BZ Tang, CE Offler, JW Patrick, C‐P Song. From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology. Exploration, 2021, 1, 9-20.

127. O Bondarenko, M Mortimer, A Kahru, N Feliu, I Javed, A Kakinen, S Lin, T Xia, Y Song, TP Davis, I Lynch, WJ Parak, DT Leong, PC Ke, C Chen, Y Zhao*. Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade. NanoToday, 2021, 39, 101184.

126. Y Li, H Tang, H Zhu, A Kakinen, D Wang, N Andrikopoulos, Y Sun, A Nandakumar, E Kwak, TP Davis, DT Leong*, F Ding*, and PC Ke*. Ultrasmall Molybdenum Disulfide Quantum Dots Cage Alzheimer’s Amyloid Beta to Restore Membrane Fluidity. ACS Appl. Mater. Interfaces 2021, 13, 25, 29936–29948. 



125. K Zheng, MI Setyawati, DT Leong, J Xie. Overcoming bacterial physical defenses with molecule-like ultrasmall antimicrobial gold nanoclusters. Bioactive Materials 2020. 6, 941-950.

124. K Zheng, MI Setyawati, DT Leong*, J Xie*. Observing Antimicrobial Process with Traceable Gold Nanoclusters. Nano Research 2020.

123. X Liu, X Li, L Jia, G Cheng, DT Leong*, Q Xue*. 3-D DNA Nanodevices as a Point-of-Care Sensitive Detection of Antibiotics adulterated Food. Chemical Comms 2020.

122. C Yao, W Wu, Han Tang, X Jia, J Tang, X Ruan, F Li, DT Leong, D Luo, D Yang*. Self-assembly of stem cell membrane-camouflaged nanocomplex for microRNA-mediated repair of myocardial infarction injury. Biomaterials 2020. 257, 120256.

121. X Sun*, N Ni, Y Ma, Y Wang, DT Leong*. Retooling Cancer Nanotherapeutics’ Entry into Tumors to Alleviate Tumoral Hypoxia. Small. 2020. DOI: 10.1002/smll.202003000.

120. D Wu, BL Li, Q Zhao, Q Liu, D Wang, B He, Z Wei, DT Leong*, G Wang*, H Qian*. Assembling Defined DNA Nanostructure with Nitrogen‐Enriched Carbon Dots for Theranostic Cancer Applications. Small. 2020, 16, 1906975.

119. K Ariga, X Jia, J Song, JP Hill, DT Leong, Y Jia, J Li. Nanoarchitectonics beyond Self‐Assembly: Challenges to Create Bio‐Like Hierarchic Organization. Angewandte Chemie International Edition 2020. (In Press)

118. C Sevencan, RSA McCoy, P Ravisankar, M Liu, S Govindarajan, J Zhu, BH Bay, DT Leong*. Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy. Advanced Therapeutics. 2020, 3, 1900201.

117. J Zhu, C Sevencan, M Zhang, RSA McCoy, X Ding, J Ye, J Xie, K Ariga, J Feng, BH Bay, DT Leong*. Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy. ACS Nano. 2020 14 (3), 3259-3271.

116. BL Li, HL Zou, HQ Luo, DT Leong*, NB Li. Layered MoS 2 defect-driven in situ synthesis of plasmonic gold nanocrystals visualizes the planar size and interfacial diversity. Nanoscale. 2020, 12, 11979-11985.

115. H Zhu, N Ni, S Govindarajan, X Ding, DT Leong*. Phototherapy with layered materials derived quantum dots. Nanoscale. 2020, 12, 43-57.

114. BL Li, R Li, HL Zou, K Ariga, NB Li, DT Leong*. Engineered functionalized 2D nanoarchitectures for stimuli-responsive drug delivery. Materials Horizons. 2020, 7, 455-469.



113. J.K. Tee, M.I. Setyawati, F. Peng, D.T. Leong*, H.K. Ho*. Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness. Nanotoxicology. 2019. DOI: 10.1080/17435390.2019.1571646.

112. E Tan, BL Li, K Ariga, CT Lim, S Garaj, DT Leong*. Toxicity of Two-Dimensional Layered Materials and Their Heterostructures. Bioconjugate Chemistry. 2019, 30, 2287-2299.

111. JK Tee, LX Yip, ES Tan, S Santitewagun, A Prasath, PC Ke, HK Ho, DT Leong*. Nanoparticles’ interactions with vasculature in diseases. Chemical Society Reviews. 2019, 48, 5381-5407.

110. JK Tee, LY Ng, HY Koh, DT Leong*, HK Ho*. Titanium dioxide nanoparticles enhance leakiness and drug permeability in primary human hepatic sinusoidal endothelial cells. International Journal of Molecular Sciences. 2019, 20, 35.

109. JK Tee, MI Setyawati, F Peng, DT Leong*, HK Ho*. Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness. Nanotoxicology. 2019, 13, 682-700.

108. F Peng^, MI Setyawati^, JK Tee^, X Ding, J Wang, ME Nga, HK Ho*, DT Leong*. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature Nanotechnology. 2019, 14, 279–286.

107. X. Ding, F. Peng, Z. Jun, W. Gong, G. Slaven, K. P. Loh, C. T. Lim*, D. T. Leong*. Defect Engineered Bioactive Transition Metals Dichalcogenides Quantum Dots. Nature  Communications, 2019, 10, 41. (Free open access)

106. BL Li, J Wang, ZF Gao, H Shi, HL Zou, K Ariga, D.T. Leong*. Ratiometric Immunoassays Built from Synergistic Photonic Absorption of Size-Diverse Semiconducting MoS2 Nanostructures. Materials Horizons, 2019, 6, 563-570. (for download until mid May 2019; Manuscript ID: C8MH01232F; PW: 574357) 


105. Q Yao, X Yuan, T Chen, DT Leong, J Xie*. Engineering Functional Metal Materials at the Atomic Level. Advanced Materials 2018, 30, 1802751. 

104. KP Loh, D Ho, GNC Chiu, DT Leong, G Pastorin, EKH Chow*. Clinical Applications of Carbon Nanomaterials in Diagnostics and Therapy. Advanced Materials 2018, 30, 1802368. 

103. F Peng, JK Tee, MI Setyawati, X Ding, HLA Yeo, YL Tan, DT Leong*, HK Ho*. Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis. ACS Applied Mat Interfaces 2018, 10, 31938–31946.

102. MI Setyawati, C Sevencan, BH Bay, J Xie, Y Zhang, P Demokritou, DT Leong*. Nano-TiO2drives epithelial –mesenchymal transition in intestinal epithelial cancer cells. SMALL 2018, 14, 1800922. 

101. J Wang, L Zhang, F Peng, X Shi*, DT Leong*. Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles. Chemistry of Materials 2018, 30, 3759–3767.

100. DMY Tay, BL Li*, ESL Tan, KP Loh, DT Leong*. Precise Single-Step Electrophoretic Multi-Sized Fractionation of Liquid-Exfoliated Nanosheets. Advanced Functional Materials 2018, 28, 1801622.

99. K Zheng, MI Setyawati, DT Leong*, J Xie*. Surface Ligand Chemistry of Gold Nanoclusters Determines Their Antimicrobial Ability. Chemistry of Materials 2018, 30, 8, 2800-2808.


96. Q Yao, X Yuan, V Fung, Y Yu, DT Leong, D Jiang, J Xie*. Understanding seed-mediated growth of gold nanoclusters at molecular level. Nature Communications 2017, 8, 927.

95. BL Li, MI Setyawati, HL Zou, JX Dong, HQ Luo, NB Li, DT Leong*. Emerging 0D Transition‐Metal Dichalcogenides for Sensors, Biomedicine, and Clean Energy. SMALL 2017, 13, 1700527.

94. Goswami N, Luo Z, Yuan X*, Leong DT, Xie J*. Engineering Gold-Based Radiosensitizers for Cancer Radiotherapy. Materials Horizons 2017, 4, 817-831.

93. Zheng K, Setyawati MI*, Leong DT*, Xie J*. Antimicrobial Gold Nanoclusters. ACS Nano 2017, 11, 6904–6910. (Featured in NanotechWeb)

92. Wang J, Leong MC, Leong EZ, Kuan WS*, Leong DT*. Clinically Relevant Detection Of Streptococcus Pneumoniae With DNA-Antibody Nanostructures. Analytical Chemistry 2017, 89, pp 6900–6906.

91. Setyawati MI*, Tay CY, Bay BH, Leong DT*. Gold Nanoparticles Induced Endothelial Leakiness Depends On Particle Size And Endothelial Cell Origin. ACS Nano 2017, 11, 5020–5030.

90. Li BL, Setyawati MI, Chen L, Xie J, Ariga K, Lim CT, Garaj S, Leong DT*. Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery. ACS Applied Mat Interfaces 2017, 9, 15286–15296.

89.  Tay CY*, Setyawati MI, Leong DT*. Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability. ACS Nano 2017, 11, 2764–2772.

88. Setyawati MI*, Leong DT*. Mesoporous Silica Nanoparticles as an Anti-Tumoral-Angiogenesis Strategy. ACS Applied Materials Interfaces 2017, 9, 6690–6703.

87. Qian H, Tay CY, Setyawati MI, Chia SL, Lee DS, Leong DT*. Protecting microRNAs from RNase degradation with steric DNA nanostructures. Chemical Science 2017, 8, 1062 – 1067. (Free Open Access)

86. Chua H^, Setyawati MI^, Li H, Fang C, Leong DT*, George S*. Particulate matters (PMs) collected from a classroom and corridor showed oxidative stress dependent cytotoxicity and leakiness in human microvascular endothelial cells. Indoor Air 2017, 27, 551-563.


85. Chia SL, Leong DT*. Reducing ZnO nanoparticles toxicity through silica coating. Heliyon 2016, 2, e00177. (Free open access)

84. Yang H, Nguyen KT, Leong DT, Tan NS, Tay CY*. A soft material approach to induce oxidative stress in mesenchymal stem cells for functional tissue repair. ACS Applied Materials & Interfaces 2016, 8, 26591–26599.

83. Zheng K, Setyawati MI*, Lim T-P, Leong DT*, Xie J*. Antimicrobial Cluster Bombs: Silver Nanoclusters Packed with Daptomycin. ACS Nano 2016. 10, 7934–7942.

82. Setyawati MI, Kutty RV, Leong DT*. DNA nanostructures carrying stoichiometrically definable antibodies. SMALL 2016, 12, 5601–5611.

81. Li BL, Wang JP, Zou HL, Garaj S, Lim CT, Xie JP, Li NB, Leong DT*. Low-Dimensional Transition Metal Dichalcogenide Nanostructures Based Sensors. Advanced Functional Materials 2016, 26, 7034–7056. 

80. Goswami, N.; Lin, F.; Liu, Y., Leong, D. T. and Xie, J*. Highly luminescent thiolated gold nanoclusters impregnated in nanogel. Chemistry of Materials 2016. 28, 4009-4016.

79. Li M, Neoh KG* , Xu LA, Yuan L, Leong DT, Kang ET, Chua KL, Hsu LY.Sugar-grafted cyclodextrin nanocarrier as a “trojan Horse” for potentiating antibiotic activity.  Pharmaceutical Research 2016, 33,  1161-1174.

78. Tee JK, Ong CN, Bay BH, Ho HK, Leong DT*. Inorganic nanoparticles induced oxidative stress as an initiator to different biological endpoints. WIREs Nanomedicine & Nanobiotechnology 2016, 8, 414-438.

77. Lee DS, Qian H, Tay CY, Leong DT*. Cellular Processing and Destinies of Artificial DNA Nanostructures. Chemical Society Reviews 2016, 45, 4199-4225.

76. Tay CY*, MS Muthu, Chia SL, Nguyen KT, Feng SS, Leong DT*. Reality check for nanomaterials-mediated therapy with 3D biomimetic culture systems. Advanced Functional Materials 2016, 26, 4046-4065. VIP paper.

75. Setyawati MI, Mochalin VM, Leong DT*. Tuning Endothelial Permeability with Functionalized Nanodiamonds. ACS NANO 2016, 10, 1170–1181.

74. Menon N, Leong DT*. Cytotoxic Effects of Phosphonate-Functionalised Mesoporous Silica Nanoparticles. ACS Appl Mat Interface 2016. 8, 2416–2422. 

73. Chia SL, Tay CY, Setyawati MI, Leong DT*. Decoupling the direct and indirect biological effects of ZnO nanoparticles using a communicative dual cell type tissue construct. SMALL 2016. 12, 647-657.


72. Giovanni M, Tay CY, Setyawati MI, Xie J, Ong CN, Fan R, Yue J, Zhang L, Leong DT*. Toxicity Profiling of Water Contextual Zinc Oxide, Silver and Titanium Dioxide Nanoparticles in Human Oral and Gastrointestinal Cell Systems. Environmental Toxicology 2015, 30, 1459–1469. (Highly Cited paper 2016)

71. Setyawati MI, Tay CY, Docter D, Stauber RH, Leong DT*. Understanding and Exploiting Nanoparticles’ Intimacy with the Blood Vessel and Blood. Chemical Society Reviews 2015, 44, 8174-8199. (RSC Gold for Gold – open access).

70. Kutty RV, Chia SL, Setyawati MI, Muthu SS, Feng SS*, Leong DT*. In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer. Biomaterials 2015, 63, 58-69.

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer

69. Giovanni M, Yue J, Zhang L, Xie J, Ong CN, Leong DT*. Pro-Inflammatory Responses of RAW264.7 Macrophages when Treated with Ultralow Concentrations of Silver, Titanium Dioxide, and Zinc Oxide Nanoparticles. Journal of Hazardous Materials 2015. 297, 146-152. 

68. Tay CY, Yuan L, Leong DT*. Nature-Inspired DNA Nanosensor for Real Time In Situ Detection of mRNA in Living Cells. ACS Nano 2015, 9, 5609–5617. Featured on Nanowerk website.

67. Giovanni M, Setyawati MI, Tay CY, Hang Q, Kuan WS*, Leong DT*. Electrochemical Quantification of Escherichia coli with DNA Nanostructure. Advanced Functional Materials 2015, 25, 3840-3846. (VIP paper)

66. Setyawati MI, Tay CY, Leong DT*. Mechanistic Investigation of the Biological Effects of SiO2, TiO2, and ZnO Nanoparticles on Intestinal Cells. SMALL 2015, 11, 3458–3468. VIP paper.

65. Kutty RV, Tay CY, Chen SL, Feng SS*, Leong DT*. Anti-migratory and increased cytotoxic effects of novel dual drug loaded complex hybrid micelles in triple negative breast cancer cells. Nano Research 2015, 8, 2533–2547.

64. Zhang XD, Luo Z, Chen J, Song S, Yuan X, Shen X, Wang H, Sun Y, Gao K, Zhang L, Fan S, Leong DT, Guo M*, Xie J.* Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance. Scientific Reports 2015, 5, 8669.

63. Tay CY, Menon N, Leong DT, Tan LP*. Molecular Architecture Governs Cytotoxicity and Gene Transfection Efficacy of Polyethylenimine Based Nanoplexes in Mammalian Cell Lines. Journal of Inorganic and Organometallic Polymers and Materials 2015, 25, 301-311.


62. Zhang XD^, Luo Z^, Chen J, Wang H, Song S, Shen X, Long W, Sun YM, Fan S, Zheng K, Leong DT*, Xie, J.* Storage of gold nanoclusters in muscle leads to their biphasic in vivo clearance. SMALL  2015, 11, 1683–1690. Featured in


61. Chia SL, Tay CY, Setyawati MI, Leong DT*. Biomimicry 3D Gastrointestinal Spheroid Platform for the Assessment of Toxicity and Inflammatory Effects of Zinc Oxide Nanoparticles. SMALL 2015, 11, 702-712. (Featured in (Frontispiece – see above).


60. Tay CY*, Setyawati MI, Xie J, Parak WJ, Leong DT*. Back to basics: Exploiting the innate physico-chemical characteristics of nanomaterials for biomedical applications. Advanced Functional Materials 2014, 24, 5936–5955. Featured in (Highly Cited paper 2015, 2016  – ISI Citations)

toc afm

59. Luo Z, Nachammai V, Zhang B, Yan N, Leong DT, Jiang D, Xie JP*. Toward Understanding the Growth Mechanism: Tracing All Stable Intermediate Species from Reduction of Au(I)–Thiolate Complexes to Evolution of Au25 Nanoclusters. J Am Chem Soc 2014, 136, 10577-10580.

58. Leong DT*, Ng KW*. Probing the Relevance of 3D Cancer Models in Nanomedicine Research. Advanced Drug Delivery Reviews 2014, 79-80, 95-106.


57. Feng G, Tay CY, Chui XQ, Tomczak N, Liu R, Liu J, Zhao Z, Tang BZ, Leong DT*, Liu B*. Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking. Biomaterials 2014, 35, 8669-8677.

56. Setyawati MI^, Kutty RV^, Tay CY, Yuan X, Xie J*, Leong DT*. Novel theranostic DNA nano-scaffolds for the simultaneous detection and killing of Escherichia coli and Staphylococcus aureus. ACS Applied Materials and Interfaces 2014.  6,  21822–21831. Invited article for Special Issue on “Theranostics”. Highlighted in ACS PressPacs 9th July 2014. Featured in Sciencedaily, and Nanowerk and Nanowerk Spotlight.

theranostic DP antimicrobial


55. Tay CY*, Leong DT*. Inorganic nanoparticles as tubulin binding agents for cancer therapy. Nanomedicine 2014, 9, 2075-2077.

54. Setyawati MI, Tay CY, Leong DT*. The gap between endothelial cells: key to the quick escape of nanomaterials? Nanomedicine 2014, 9, 1591-1594.

53. Kodali A, Lim TC, Leong DT, Tong YW*. Cell-Microsphere Constructs Formed with Human Adipose Derived Stem Cells and Gelatin Microspheres Promotes Stemness, Differentiation and Controlled Pro-Angiogenic potential.  Macromolecular Bioscience 2014, 14, 1458-1468.

52. Yuan L, Giovanni M, Xie J, Fan CH, Leong DT*. Ultrasensitive IgG quantification using DNA nano-pyramids. Nature Publishing Group Asia Materials. 2014, 6, e112. doi:10.1038/AM.2014.46 (open access)

51. Setyawati MI, Yuan X, Xie J*, Leong DT*. The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells. Biomaterials 2014, 35(25): 6707-6715. doi: 10.1016/j.biomaterials.2014.05.007

50. Tay CY, Fang W, Setyawati MI, Chia SL, Tan KS, Hong CHL*, Leong DT*. Nano-Hydroxyapatite and nano-Titanium dioxide exhibit different sub- cellular distribution and apoptotic profile in human oral epithelium. ACS Applied Materials & Interfaces. 2014; 6 (9), pp 6248–6256. DOI:10.1021/am501266a. (Highly cited paper 2015 – ISI Citations)

49. Zhang X-D, Luo, Z, Chen J, Shen X, Song S, Sun Y, Fan S, Fan F, Leong DT, Xie J*. Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy. Advanced Materials 2014. 26: 4565–4568. DOI: 10.1002/adma.201400866. (Highly cited paper 2015 – ISI Citations)

48.  Muthu MS, Leong DT, Mei L, Feng S-S*. Nanotheranostics ˗ Application and Further Development of Nanomedicine Strategies for Advanced Theranostics. Theranostics 2014. 4(6): 660-677. doi:10.7150/thno.8698.(Highly cited paper 2015, 2016 – ISI Citations)

47. Kutty RV, Leong DT, Feng SS*. Nanomedicine for Treatment of Triple Negative Breast Cancer. Nanomedicine. 2014. 9(5): 561-564. doi: 10.2217/nnm.14.19.

46. Tay CY, Yu Y, Setyawati MI, Xie J, Leong DT*. Presentation matters: Identity of gold nanoclusters capping agent governs intracellular uptake and cell metabolism. Nano Research 2014. 7(6), 805-815. doi: 10.1007/s12274-014-0441-z

45Setyawati MI, Tay CY, Leong DT*. Exploiting cancer’s anti-oxidative weakness through p53 with nanotoxicology. Nanomedicine. 2014, 9(4):369-371, doi: 10.2217/NNM.14.6. (invited editorial article)

44. Yuan X, Zhang B, Luo Z, Yao Q, Leong DT, Yan N*, J Xie*. Balancing the Rate of Cluster Growth and Etching for Gram-Scale Synthesis of Mono-, Bi- and Multi-Thiolate-Protected Au25 Nanoclusters with Atomic Precision. Angewandte Chemie 2014. Apr 25;53(18):4623-7. DOI: 10.1002/anie.201311177. (Highly cited paper 2015 – ISI Citations)

43. Yu Y, Luo Z, Chevrier DM, Leong DT, Zhang P, Jiang DE, Xie J*. Identification of a Highly Luminescent Au22(SG)18 Nanocluster. J Am Chem Soc. 2014 Jan;136(4):1246-1249. doi: 10.1021/ja411643u (Highly cited paper and also HOT Paper 2014, 2015 – ISI Citations)

42. Setyawati MI, Xie J, Leong DT*. Phage based green chemistry for gold ions reduction and gold retrieval. ACS Applied Mat Interfaces 2014, 6 (2), pp 910–917. DOI: 10.1021/am404193j.

41. Tan GR, Feng SS, Leong DT*.The reduction of anti-cancer drug antagonism by the spatial protection of drugs with PLA-TPGS nano particles. Biomaterials. 2014, 35(9): 3044-3051.DOI:10.1016/j.biomaterials.2013.12.033. (Highly cited paper 2014, 2015 – ISI Citations)

40. Tay CY, Cai PQ, Setyawati MI, Fang W, Tan LP, Hong CHL, Chen X*, Leong DT*. Nanoparticles strengthen intracellular tension and retard cellular migration. Nano Letters. 2014, 14(1): 83-88. doi: 10.1021/nl4032549. (Highly cited paper 2014, 2015, 2016 – ISI Citations)

tay Nanoletters 2014

39. ^Yuan X, ^Setyawati MI, Leong DT*, Xie J*. Ultrasmall Ag+-rich nanoclusters as highly efficient nanoreservoirs for bacterial killing. Nano Research 2014. 7(3), 301-307. doi: 10.1007/s12274-013-0395-6.

38. Dou X, Yuan X, Yu, Y, Luo Z, Yao Q, Leong DT, Xie J*. Lighting Up Thiolated Au@Ag Nanoclusters via Aggregation-Induced Emission, Nanoscale 2014, 6: 157-161. doi: 10.1039/C3NR04490D. (Highly cited paper 2015 – ISI Citations)



37. Setyawati MI, Tay CY, Leong DT*. Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway. Biomaterials 2013, 34(38):10133-42. doi: 10.1016/j.biomaterials.2013.09.024.

36. van der Deen M, Taipaleenmaki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ*. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013. Jul 19;288(29):21307-19. doi: 10.1074/jbc.M112.445890.

35. Tay CY^, Fang W^, Setyawati MI, Sum CP, Chen X, Hong CHL*, Leong DT*. Reciprocal response of human oral epithelial cells to internalized silica nanoparticles. Particle and Particle Systems Characterization. 2013. 30: 784–793. DOI: 10.1002/ppsc.201300111.

34. Setyawati MI, Tay CY, Chia SL, Goh SL, Fang W, Neo MJ, Chong HC, Tan SM, Loo SC, Ng KW, Xie JP, Ong CN, Tan NS, Leong DT*. TiO2 nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin. Nature Communications. 2013. 4, 1673, DOI: 10.1038/NCOMMS2655 

33. Yu T, Chua CK, Tay CY, Wen F, Yu H, Chan JK, Chong MSK, Leong DT, Tan LP*. A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation. Macromolecular Bioscience. 2013 Jun;13(6):799-807. doi: 10.1002/mabi.201200481.

32. Tay CY, Koh CG, Tan NS, Leong DT, Tan LP*. Mechano-regulation of stem cell fate via micro-nanoscale manipulation for regenerative medicine. Nanomedicine. 2013 Apr;8(4):623-38. doi: 10.2217/nnm.13.31.

31. Yuan X, Tay Y, Dou X, Luo Z, Leong DT, Xie J*. Glutathione-Protected Silver Nanoclusters as Cysteine-Selective Fluorometric and Colorimetric Probe. Analytical Chemistry. 2013 Feb 5;85(3):1913-9. doi: 10.1021/ac3033678. (Highly cited paper 2013, 2014, 2015 – ISI Citations)

30. Yuan X, Setyawati MI, Tan AS, Ong CN, Leong DT*, Xie J*. Highly Luminescent Silver Nanoclusters with Tunable Emissions: Cyclic Reduction-Decomposition Synthesis and Antimicrobial Property. Nature Publishing Group Asia Materials. (2013) 5, e39; doi:10.1038/am.2013.3. (Highly cited paper 2013, 2014, 2015 – ISI Citations)

29. Wu YL, Putcha N, Ng KW, Leong DT, Lim CT, Loo SC*, Chen X*. Biophysical Responses upon the Interaction of Nanomaterials with Cellular Interfaces. Accounts of Chemical Research. 2013, 46 (3), pp 782–791. DOI: 10.1021/ar300046u  

28. Zhao Y, Howe JLC, Yu Z, Leong DT, Chu JJH, Loo JSC and Ng KW*. Exposure to Titanium Dioxide Nanoparticles Induces Autophagy in Primary Human Keratinocytes. SMALL 2013 Feb 11; 9(3): 387-92. doi: 10.1002/smll.201201363.

27. Setyawati MI, Fang WR, Chia SL, Leong DT*. Nanotoxicology of common metal oxide based nanomaterials: their ROS-y and non-ROS-y consequences. Asia Pacific Journal of Chemical Engineering. Mar/Apr 2013; 8(2):205-217. doi: 10.1002/apj.1680.

26. Yu HY, Tay CY, Pal M, Leong WS, Li HS, Li H, Wen F, Leong DT, Tan LP*. A Novel Bio-inspired Platform to Modulate hMSCs Myogenic Differentiation Regulation. Advanced Healthcare Materials 2013 Mar; 2(3):442-9. doi: 10.1002/adhm.201200142.



25. Setyawati MI, Khoo, PKS, Eng BH, Xiong SJ, Zhao XX, Das G, Tan T, Loo J, Leong DT, Ng KW*. Cytotoxic and Genotoxic Characterization of Titanium Dioxide, Gadolinium Oxide and Poly(lactic-co-glycolic acid) Nanoparticles in Human Fibroblasts. Journal of Biomedical Materials Research, Part A 2012. Volume 101A, 633-640.

24. Luo ZT, Yuan X, Yu Y, Zhang Q, Leong DT, Lee JY, Xie J*. From the Aggregation-Induced Emission of Au(I)-Thiolate Complexes to Ultra-Bright Au(0)@Au(I)-Thiolate Core-Shell Nanoclusters. Journal of the American Chemical Society 2012 Oct 10;134(40):16662-70. doi: 10.1021/ja306199p. (Highly cited paper 2012,2013,2014, 2015 – ISI Citations)

23. Chin CF, Tian Q, Fang WR, Setyawati MI, Tan E, Leong DT, Ang WH*. Tuning the activity of platinum(IV) anticancer complexes through asymmetric acylation. Journal of Medicinal Chemistry 2012. Sep 13;55(17):7571-82. doi: 10.1021/jm300580y.

22. Yu H, Lui YS, Xiong SJ, Leong WS, Wen F, Nurkahfianto H, Rana S, Leong DT, Ng KW, Tan LP*. Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells. Stem Cells and Development 2012, 22, 136-147.  doi:10.1089/scd.2012.0160.

21. Tripathi A, Fang WR, Leong DT*, Tan LT*. Biochemical Studies on the Lagunamides, Potent Cytotoxic Cyclic Depsipeptides from the Marine Cyanobacterium Lyngbya majuscula. Marine Drugs 2012, 10, 1126-1137. doi:10.3390/md10051126.

20. Leong DT*, Abraham MC, Gupta A, Lim TC, Chew FT, Hutmacher DW. ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells. Journal of Cellular Biochemistry. 2012 Aug;113(8):2744-53, doi10.1002/jcb.24150

19. Pereira BP*, Tan BL, Han HC, Zou Y, Khin ZA, Leong DT*. Intramuscular Nerve Damage in Lacerated Skeletal Muscles may direct the Inflammatory Cytokine Response During Recovery. Journal of Cellular Biochemistry 2012 Jul;113(7):2330-45 DOI: 10.1002/jcb.24105

18. Koo XX, Fang WR, Salto-Tellez M, Leong DT*. Coexpressing shRNA with fluorescence tags for quantification of cell migration studies. Molecular Biology Reports 2012 Jul;39(7):7695-703, doi:10.​1007/​s11033-012-1605-0.

17. Li HQ, Wen F, Wong YS, Boey F, Subbu VS; Leong DT, Ng KW, Ng LK, Tan LP*. Direct laser machining induced topographic pattern promotes human mesenchymal stem cell differentiation towards myogenic lineage. Acta Biomaterialia 2012, 8, 531-539. doi:10.1016/j.actbio.2011.09.029.



16. Ng KW, Khoo PKS, Heng BC, Setyawati MI, Tan EC, Zhao XX, Xiong SJ, Fang WR, Leong DT*, Loo JSC*. Cellular DNA Damage Response to Zinc Oxide Nanoparticles Hinges on the Tumor Suppressor p53 Pathway. Biomaterials 2011 Nov;32(32):8218-25. doi:10.1016/j.biomaterials.2011.07.036.

15. Huang RL, Teo ZQ, Chong HC, Zhu PC, Tan MJ, Tan CK, Lam CR, Sng MK, Leong DT, Tan SM, Kersten S, Ding JL, Li HY, Tan NS*. ANGPTL4 modulates vascular junction integrity by integrin a5b1-Rac/PAK signaling and the disruption of intercellular VE-cadherin and claudin-5 clusters. BLOOD 2011 Oct 6;118(14):3990-4002. doi: 10.1182/blood-2011-01-328716.

14. Tay CY, Pal M, Yu H, Leong WS, Tan NS, Ng KW, Venkatraman S, Boey F, Leong DT*, Tan LP*. Bio-inspired Micropatterned Platform to Steer Stem Cell Differentiation. SMALL 2011, 7, 1416-1421, doi: 10.1002/smll.201002298.


2004 to 2010 (Before joining ChBE in Nov 2010)

13. *Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Res. 2010 Oct 28;12(5):R89. doi: 10.1186/bcr2762. (Highly accessed rating)

12. Tay CY, Yu H, Pal M, Leong WS, Tan NS, Ng KW, Leong DT, Tan LP*. Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage.  Exp Cell Res. 2010 Apr 15;316(7):1159-68. doi: 10.1016/j.yexcr.2010.02.010. 

11. Pereira BP, Zhou Y, Gupta A, Leong DT, Aung KZ, Ling L, Pho RW, Galindo M, Salto-Tellez M, Stein GS, Cool SM, van Wijnen AJ*, Nathan SS*. Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). J Cell Physiol. 2009 Dec;221(3):778-88. doi: 10.1002/jcp.21921.

10. Das K, Leong DT, Gupta A, Shen L, Putti T, Stein GS, van Wijnen AJ, Salto-Tellez M*. Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer. Eur J Cancer. 2009 Sep;45(13):2239-48. doi: 10.1016/j.ejca.2009.06.021.

9. Rider DA, Dombrowski C, Sawyer AA, Ng GH, Leong D, Hutmacher DW, Nurcombe V, Cool SM*. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells. 2008 Jun;26(6):1598-608. doi: 10.1634/stemcells.2007-0480.

8. Gupta A, Leong DT, Bai HF, Singh SB, Lim TC, Hutmacher DW*. Osteo-maturation of adipose-derived stem cells required the combined action of vitamin D3, beta-glycerophosphate, and ascorbic acid. Biochem Biophys Res Commun. 2007 Oct 12;362(1):17-24.

7. Leong DT, Nah WK, Gupta A, Hutmacher DW*, Woodruff MA. The osteogenic differentiation of adipose tissue-derived precursor cells in a 3D scaffold/matrix environment. Curr Drug Discov Technol. 2008 Dec;5(4):319-27

6. Leong DT, Gupta A, Bai HF, Wan G, Yoong LF, Too HP, Chew FT, Hutmacher DW*. Absolute quantification of gene expression in biomaterials research using real-time PCR. Biomaterials. 2007 Jan;28(2):203-10.

5. Leong DT, Abraham MC, Rath SN, Lim TC, Chew FT, Hutmacher DW*. Investigating the effects of preinduction on human adipose-derived precursor cells in an athymic rat model. Differentiation. 2006 Dec;74(9-10):519-29.

4. Leong DT, Khor WM, Chew FT, Lim TC, Hutmacher DW*. Characterization of osteogenically induced adipose tissue-derived precursor cells in 2-dimensional and 3-dimensional environments. Cells Tissues Organs. 2006;182(1):1-11.

3. Leong DT, Hutmacher DW, Chew FT, Lim TC*. Viability and adipogenic potential of human adipose tissue processed cell population obtained from pump-assisted and syringe-assisted liposuction. J Dermatol Sci. 2005 Mar;37(3):169-76.

2. Ng KW^, Leong DT^, Hutmacher DW. The challenge to measure cell proliferation in two and three dimensions. Tissue Eng. 2005 Jan-Feb;11(1-2):182-91.

1. Leong TW, Chew FT, Hutmacher DW*. Isolating bone marrow stem cells using sieve technology. Stem Cells. 2004;22(6):1123-5.


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