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Nanomaterials induced endothelial leakiness (NanoEL)

Certain nanomaterials causes endothelial cell leakiness. Novel concept of crossing the endothelial cell barriers.

Li Y, Ni N, Lee M, Wei W, Andrikopoulos N, Kakinen A, Davis TP, Song Y, Ding F, Leong DT*, Ke PC*. Endothelial leakiness elicited by amyloid protein aggregation. Nature Communications 2024, 15, 613 .

Wang Q, Liang Q, Dou J, Zhou H, Zeng C, Pan H, Shen Y, Li Q, Liu Y, Leong DT*, Jiang W*, Wang Y*. Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours. Nature Nanotechnology 2024, 19, 95-105.

MI Setyawati, Q Wang, N Ni, JK Tee, K Ariga, PC Ke, HK Ho, Y Wang*, DT Leong*. Engineering tumoral vascular leakiness with gold nanoparticles. Nature Communications 2023, 14, 4269.

F Peng^, MI Setyawati^, JK Tee^, X Ding, J Wang, ME Nga, HK Ho*, DT Leong*. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature Nanotechnology. 2019. 14, 279–286.

Setyawati MI, Tay CY, Chia SL, Goh SL, Fang W, Neo MJ, Chong HC, Tan SM, Loo SC, Ng KW, Xie JP, Ong CN, Tan NS, Leong DT*. TiO2 nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin. Nature Communications. 2013. 4, 1673.

JK Tee, MI Setyawati, F Peng, DT Leong*, HK Ho*. Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness. Nanotoxicology. 2019. DOI: 10.1080/17435390.2019.1571646.

J Wang, L Zhang, F Peng, X Shi*, DT Leong*. Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles. Chemistry of Materials 2018, 30, 3759–3767.

F Peng, JK Tee, MI Setyawati, X Ding, HLA Yeo, YL Tan, DT Leong*, HK Ho*. Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis. ACS Applied Mat Interfaces 2018, 10, 31938–31946.

Setyawati MI*, Tay CY, Bay BH, Leong DT*. Gold Nanoparticles Induced Endothelial Leakiness Depends On Particle Size And Endothelial Cell Origin. ACS Nano 2017, 11, 5020–5030.

Tay CY*, Setyawati MI, Leong DT*. Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability. ACS Nano 2017, 11, 2764–2772.

Setyawati MI, Mochalin VM, Leong DT*. Tuning Endothelial Permeability with Functionalized Nanodiamonds. ACS NANO 2016, 10, 1170–1181.

Setyawati MI, Tay CY, Docter D, Stauber RH, Leong DT*. Understanding and Exploiting Nanoparticles’ Intimacy with the Blood Vessel and Blood. Chemical Society Reviews 2015, 44, 8174-8199. (RSC Gold for Gold – open access)