Publications

2024

  1. Mahalakshmi Shanmugasundaram, Simin Xu, Yujie Yang, Jong Huat Tee, Terence Yin Weng Lam, and Ruowen Ge*. Ism1 deficiency in mice exacerbates bleomycin-induced pulmonary fibrosis with enhanced cellular senescence and delayed fibrosis resolution. hLife, Volume 2, Issue 7, 2024, Pages 342-359, ISSN 2949-9283, ISSN 2949-9283. Link

2023

  1. Tee Jong Huat, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y.W. Lam, Wupeng Liao, Yuansheng Yang, W.S.Fred Wong, and R. Ge*. Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice. Respiratory Research 24, 269 (2023). Link
  2. Tee Jong Huat, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y.W. Lam, Wupeng Liao, Yuansheng Yang, W.S.Fred Wong, and R. Ge*. Unveiling the role of Isthmin-1 in allergic asthma: Implications for therapeutic interventions. European Respiratory Journal 2023: OA775; DOI: 10.1183/13993003.congress-2023.OA775. Link

2022

  1. Kirman, D.C., B. Renganathan, W. K. Chui, M. W. Chen, N. A. Kaya, and R. Ge*. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis 13(2):172, 2022. Pubmed Link
  2. Nguyen N, Xu S, Lam TYW, Liao W, Wong WSF, R Ge*. ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice. Mol Med. 28(1):72, 2022. Pubmed Link
  3. Leong EWX, R Ge*. Lipid Nanoparticles as Delivery Vehicles for Inhaled Therapeutics. Biomedicines 10: 2179, 2022. Pubmed Link
  4. R Ge*. Targeting airway macrophages for inflammatory lung diseases—insights from traditional Chinese medicine. Ann Transl Med 10(20):1086, 2022. Link
  5. Lam, T. Y. W., N. Nguyen, H. Y. Peh, M. Shanmugasundaram, R. Chandna, Tee Jong Huat, C. B. Ong, M. Z. Hossain, S. Venugopal, T. Zhang, S. Xu, T. Qiu, W. T. Kong, S. Chakarov, S. Srivastava, W. Liao, J-S Kim, M. Teh, F. Ginhoux, W. S. F. Wong, and R. Ge*. ISM1 protects lung homeostasis via cell surface GRP78-mediated alveolar macrophage apoptosis. Proc Natl Acad Sci USA. 119(4): e2019161119, 2021.

2020

  1. Matthews. A. A., Ee P. L. R., Ge R. Developing inhaled protein therapeutics for lung diseases. Molecular Biomedicine. Pubmed Link
  2. Qiao, Y., Dsouza, C., Matthews, A. A., Jin, Y., He, W. Bao, J., Jiang, F., Chandra, R., Ge, R., Fu, L. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. European Journal of Medicinal Chemistry Pubmed Link

2019

1. Ge R. , Kao C. Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target. Cancers doi: 10.3390/cancers11111787 (2019). PubMed Link

2018

1. Qizhi Liu, Yongming Yuan, Feng Zhu, Yunhan Hong, Ge R. Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in cultured Medaka fish cells. Biology Open doi: 10.1242/bio.035170 (2018). PubMed Link

2. Renganathan B, Durairaj V, Kirman DC, Esubonteng PKA, Ang SK, Ge R. Recombinant TSR1 of ADAMTS5 Suppresses Melanoma Growth in Mice via an Anti-angiogenic Mechanism. Cancers doi: 10.3390/cancers10060192 (2018). PubMed Link

3. Kao C, Chandna R, Ghode A, Dsouze C, Chen M, Larsson A, Hoi LS, Wang M, Cao Z, Zhu Y, Anand GS, Ge R. Proapoptotic Cyclic Peptide BC71 Targets Cell Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine doi.org/10.1016/j.ebiom.2018.06.004 (2018). PubMed Link

4. Venugopal S, Kao C, Chandna R, Sulochana KN, Subramanian V, Chen M, Kini RM, Ge R. Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability. Angiogenesis doi: 10.1007/s10456-018-9616-7 (2018). PubMed Link

5. Chen M, Qiu T, Wu J, Yang Y, Wright GD, Wu M, Ge R. Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs. Cell Death Differ. doi: 10.1038/s41418-018-0092-9 (2018). PubMed Link

6. Tan E, Asada HH, Ge R. Extracellular vesicle-carried Jagged-1 inhibits HUVEC sprouting in a 3D microenvironment. Angiogenesis doi: 10.1007/s10456-018-9609-6 (2018). PubMed Link

2017

1. M Yin, YZ Zhu, Z Chen, M Wei, S Liu, R Ge. Pharmacology, 药理学（英文版）(2017) ISBN 978-7-117-24120-5/R·24121

2016

1. Kumar S, Chen M, Li Y, Wong FH, Thiam CW, Hossain MZ, Poh KK, Hirohata S, Ogawa H, Angeli V, Ge R. Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE−/− mice. Sci. Rep. 6, 31130; doi: 10.1038/srep31130 (2016). PubMed Link

2. Luo S, Gu X, Ma F, Liu C, Shen Y, R Ge, Zhu Y.  Loss of ZYZ451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing MnSOD and STAT3 interaction. Free Radic Biol Med  92:1-14;(2016). PubMed Link

3. Han, S X, S Kwong, R Ge, P Kolatkar, A Woods, G Blanchet and R M Kini.  Regulation of expression of snake venom toxins: silencing of prothrombin activator trocarin D by AG-rich motifs. FASEB J  30(6):2411-25;(2016). PubMed Link

4. Qian X, Li X, Ma F, Luo S, R Ge, Zhu Y.  Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy. Biochem Biophys Res Commun  473(4):931-8;(2016). PubMed Link

2015

1. Venugopal S, Chen M, Liao W, Er SY, Wong WS & Ge R. (2015). Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation. Cardiovascular Res, doi:10.1093/cvr/cvv142 PubMed Link

2. Liu Q, Wang Y, Lin F, Zheng  L, Li Y, Ge R, Hong Y. (2015) Gene transfer and genome-wide insertional mutagenesis by retroviral transduction in fish stem cells. PLoS One,  doi: 10.1371/journal.pone.0127961 PubMed Link

3. Rao N, Lee YF, Ge R (2015). Novel endogenous angiogenesis inhibitors and their therapeutic potential. Acta Pharmacol Sin, doi: 10.1038/aps.2015.73 PubMed Link

2014

1. Sharghi-Namini, S., Tan, E., Ong, L.-L. S., Ge, R., & Asada, H. H. (2014). Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment. Scientific Reports, 4. doi:10.1038/srep04031 PubMed Link

2. Chen M, Zhang Y, Yu V C, Chong Y-S, Yoshioka T & Ge R. (2014) Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ, doi: 10.1038/cdd.2014.3 PubMed Link

3. Ebrahim Attia AB, Oh P, Yang C, Tan JP, Rao N, Hedrick JL, Yang YY, Ge R. (2014) Insights into EPR effect versus lectin-mediated targeted delivery: biodegradable polycarbonate micellar nanoparticles with and without galactose surface decoration. Small, doi:10.1002/smll.201401295. PubMed Link

2013

1. Rao N, Ke Z, Liu H, Ho CJ, Kumar S, Xiang W, Zhu Y, Ge R. ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. Int J Cancer. 133(2):294-306, 2013. PubMed Link

2012

1.   Kumar S, Rao N, Ge R. Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers. 4(4) : 1252-1299, 2012. Journal Link

2. Wood LB, Ge R, Kamm RD, Asada HH. Nascent vessel elongation rate is inversely related to diameter in in vitro angiogenesis. Integr Biol (Camb). 4(9) : 1081-9, 2012. PubMed Link

3. Kumar S, Sharghi-Namini S, Rao N, Ge R. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am J Pathol. 181(3):1056-68, 2012. PubMed Link 
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4.  Ge R, Tan E, Sharghi-Namini S, Asada HH. Exosomes in Cancer Microenvironment and Beyond: have we Overlooked these Extracellular Messengers? Cancer Microenviron.  5(3):323-32, 2012. PubMed Link

5.  Li Y, Farooq M, Sheng D, Chandramouli C, Lan T, Mahajan NK, Kini RM, Hong Y, Lisowsky T, Ge R. Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis. PLoS One. 7(1):e30835, 2012. PubMed Link

6.  Hong N, Chen S, Ge R, Song J, Yi M, Hong Y. Interordinal chimera formation between medaka and zebrafish for  analyzing stem cell differentiation. Stem Cells  Dev. 21(12):2333-41, 2012. PubMed Link

7.  Zhao H, Li M, Purwanti YI, Liu R, Chen T, Li Z, Hong N, Guan G, Yin A, Xiao L, Ge R, Song J, Hong Y. Mitf is a transcriptional activator of medaka germ genes in culture. Biochimie. 94(3):759-67, 2012. PubMed Link

2011

1.  Zhang Y, Chen M, Venugopal S, Zhou Y, Xiang W, Li YH, Lin Q, Kini RM, ChongYS, Ge R. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis. 2:e153, 2011. PubMed Link

2.  Li Z, Bhat N, Manali D, Wang D, Hong N, Yi M, Ge R, Hong Y. Medaka cleavage embryos are capable of generating ES-like cell cultures. Int J Biol Sci. 7(4):418-25, 2011. PubMed Link

3.  Xiang W, Ke Z, Zhang Y, Cheng GH, Irwan ID, Sulochana KN, Potturi P, Wang Z, Yang H, Wang J, Zhuo L, Kini RM, Ge R. Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice. J Cell Mol Med. 15(2):359-74, 2011. PubMed Link

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