Our lab is delighted to announce the successful graduation of Dr. Xu Simin. We take immense pride in sharing her achievements and future endeavors with our community.
Simin’s research focused on understanding cellular senescence and its implications in pulmonary fibrosis. Cellular senescence is a state of permanent cell cycle arrest characterized by profound changes in cell behavior, chromatin structure, and the secretion of molecules that influence tumor suppression. In the lungs, senescent epithelial cells and fibroblasts significantly contribute to the development of pulmonary fibrosis. Simin’s study centered on isthmin1 (ISM1), a protein previously identified for its anti-inflammatory properties. Her research provided new insights into the role of ISM1 in cellular senescence of lung epithelial cells, suggesting a protective role of ISM1 against aging related lung diseases.
Simin successfully defended her dissertation on November 22, 2023, and officially graduated on April 30, 2024. Her pioneering work paves the way for potential therapeutic strategies targeting cellular senescence in pulmonary fibrosis and other age-related lung diseases.
Simin will continue her scientific journey as a Post-doctoral Research Fellow in the laboratory of Professor Ge at the National University of Singapore. Her future research will delve deeper into the mechanisms of senescence and innate immunology, promising further advancements in our understanding of lung health and disease. 
Stay tuned for more exciting updates on the remarkable achievements and future contributions of Dr. Xu Simin. We are immensely proud of her accomplishments and eagerly anticipate her continued impact on the scientific community.
