Click here for the full publications
Shen, Z.-A.; Guo, J.; Lu, Y. “Facile Enantioselective Synthesis of Multi-Substituted Norbornanes/Norbornenes Using a Latent Synthon Strategy”, Nat. Commun. 2024, 15, 8351.
Qi, L.-W.; Rogge, T.; Houk, K. N.; Lu, Y. “Iridium-nitrenoid enabled arene C-H functionalization”, Nat. Catal. 2024, 7, 934.
Zheng, W., Tan, B. B., Ge, S., & Lu, Y. Enantioselective Copper-Catalyzed Ring-Opening Diboration of Arylidenecyclopropanes to Access Chiral Skipped 1, 4-and 1, 3-Diboronates. J. Am. Chem. Soc. 2024, 146, 5366-5374.
Zhou, X.; Huang, Q.; Guo, J.; Dai, L.; Lu, Y., “Enantioselective De Novo Synthesis of α,α-Diaryl Ketones from Alkynes”, Angew. Chem. Int. Ed. 2023, 62, e202310078.
Zhou, X.; Huang, Q.; Guo, J.; Dai, L.; Lu, Y., Molecular editing of pyrroles via a skeletal recasting strategy. ACS Cent. Sci. 2023, 9, 1758-1767. 
Dai L.; Zhou, X.; Guo, J.; Dai, X.; Huang, Q.; Lu, Y. “Diastereo- and atroposelective synthesis of N-Arylpyrroles enabled by light-induced phosphoric acid catalysis”, Nat. Commun. 2023, 14, 4813.
Wu, Z.; Wu, M.; Zhu, K.; Wu, J.; Lu, Y. “Photocatalytic coupling of electron-deficient alkenes using oxalic acid as a traceless linchpin”, Chem 2023, 9, 978.
Tan, C. X. A.; Li, R.; Zhang, F.; Dai, L.; Ullah, N.; Lu, Y. “Synthesis of axially chiral CF3-substituted 2-arylpyrroles by sequential phosphine-catalysed asymmetric [3+2] annulation and oxidative central-to-axial chirality transfer”, Angew. Chem. Int. Ed. 2022, 134, e202209494.
Huang, Q.; Chen, Y.; Zhou, X.; Dai, L.; Lu, Y. “Nickel-hydride-catalyzed diastereo- and enantioselective hydroalkylation of cyclopropenes”, Angew. Chem. Int. Ed. 2022, 61, e202210560.
Dai, L.; Guo, J.; Huang, Q.; Lu, Y., Asymmetric multifunctionalization of alkynes via photo-irradiated organocatalysis. Sci. Adv. 2022, 8, eadd2574.
Mei, G.-J.; Koay, W. L.; Guan, C.Y.; Lu, Y., Atropisomers beyond the C–C axial chirality: Advances in catalytic asymmetric synthesis. Chem 2022, 8, 1855.
Zhang, F.; Dai, X.; Dai, L.; Zheng, W.; Chan, W.-L.; Tang, X.; Zhang, X.; Lu, Y., Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines. Angew. Chem. Int. Ed. 2022, 61, e202203212.
Chen Y.; Zhu, K.; Huang, Q.; Lu, Y. “Regiodivergent Sulfonylarylation of 1,3-Enynes via Nickel/Photoredox Dual Catalysis”, Chem. Sci. 2021, 12, 13564.
Mei, G.-J.; Wong, J. J.; Zheng, W.; Nangia, A. A.; Houk, K. N.; Lu, Y. “Rational Design and Atroposelective Synthesis of N–N Axially Chiral Compounds”, Chem 2021, 7, 2743.
Chen Y.; Wang, J.; Lu, Y. “Decarboxylative 1,4-Carbocyanation of 1,3-Enynes to Access Tetra-substituted Allenes via Copper/Photoredox Dual Catalysis”, Chem. Sci. 2021, 12, 11316.
Wang, N.; Wu, Z.; Wang, J.; Ullah, N.; Lu, Y. “Recent Applications of Asymmetric Organocatalytic Annulation Reactions in Natural Products Synthesis”, Chem. Soc. Rev. 2021, 50, 9766.
Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X. “Concise, scalable and enantioselective total synthesis of prostaglandins‘, Nat. Chem. 2021, 13, 692.
Mei, G.-J.; Koay, W. L.; Tan, C. X. A.; Lu, Y. “Catalytic asymmetric preparation of pyrroloindolines: strategies and applications to total synthesis”, Chem. Soc. Rev. 2021, 50, 5985.
Tang, X.; Tan, C. X. A.; Chan, W.-L.; Zhang, F.; Zheng, W.; Lu, Y. “Dielectrophilic Allenic Ketone-Enabled [4 + 2] Annulation with 3,3’-Bisoxindoles: Enantioselective Creation of Two Contiguous Quaternary Stereogenic Centers”, ACS Catal. 2021, 11, 1361.
Bai, X.; Wu, C.; Ge, S.; Lu, Y. “Pd/Cu-Catalyzed Enantioselective Sequential Heck-Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers Centers”, Angew. Chem. Int. Ed., 2020, 59, 2764. DOI: 10.1002/anie.201913148.
Mei, G.-J.; Tang, X.; Tasdan, Y.; Lu, Y. “ Enantioselective Dearomatization of Indoles via an Azoalkene-enabled (3+2) Reaction: Facile Access to Pyrroloindolines”, Angew. Chem. Int. Ed. 2020, 59, 648.
Wu, M.; Han, Z.; Li, K.; Wu, J.; Ding, K. Lu, Y. “Cyclohexyl-Fused, Spirobiindane-derived, Phosphine-catalyzed Synthesis of Tricyclic γ-Lactams and Kinetic Resolution of γ-Substituted Allenoates”, J. Am. Chem. Soc., 2019, 141, 16362.
Chan, W.-L.; Tang, X.; Zhang, F.; Quek, G.; Mei, G.-J.; Lu, Y. “Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers”, Angew. Chem. Int. Ed. 2019, 58, 6260 (a VIP paper).
Li, K.; Gonçalves, T. P.; Huang, K.-W.; Lu, Y. “Dearomatization of 3-Nitroindoles by a Phosphine-catalyzed Enantioselective [3+2] Annulation Reaction”, Angew. Chem. Int. Ed. 2019, 58, 5427.
Ni, H.; Chan, W.-L.; Lu, Y. “Phosphine-catalyzed Asymmetric Organic Reactions”, Chem. Rev. 2018, 118, 9344. (One of the top 3 most read articles in Chemical Reviews in September/October 2018).
Ni, H.; Tang, X.; Zheng, W.; Yao, W.; Ullah, N.; Lu, Y. “Enantioselective Phosphine-Catalyzed Formal [4+4] Annulation of a,b-Unsaturated Imines and Allene Ketones: Construction of Eight-membered Rings”, Angew. Chem. Int. Ed. 2017, 56, 14222 (highlighted in SYNFACTS 2018, 89).
Wang, T.; Han, X.; Zhong, F.; Yao, W.; Lu, Y. “Amino Acid-derived Bifunctional Phosphines for Enantioselective Transformations”, Acc. Chem. Res. 2016, 49, 1369. (one of the Most Read Articles in July/August 2016).
Dou, X.; Lu, Y.; Hayashi, T. “Base Free Conditions for Rhodium-Catalyzed Asymmetric Arylation to Produce Stereochemically Labile α-Aryl Ketones”, Angew. Chem. Int. Ed. 2016, 55, 6739 (highlighted in SYNFACTS 2016, 831).
Han, X.; Chan, W.-L.; Yao, W., Wang, Y.; Lu, Y. “Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates”, Angew. Chem. Int. Ed. 2016, 55, 6492.
Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.; Lu, Y. “Regiodivergent Enantioselective g-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of a,a-Disubstituted a-Amino Acids and N,O-Acetal Derivatives”, J. Am. Chem. Soc. 2016, 138, 265 (highlighted in SYNFACTS 2016, 309).
Yao, W.; Dou, X.; Wen, S.; Wu, J.; Vittal, J. J.; Lu, Y. “Enantioselective Desymmetrization of Cyclohexadienones via an Intramolecular Rauhut–Currier Reaction of Allenoates”, Nat. Commun. 2016, 7, 13024.
Xu, L.-W.; Chen, Y.; Lu, Y. “Catalytic Silylations of Alcohols: Turning Simple Protecting-Group Strategies into Powerful Enantioselective Synthetic Methods”, Angew. Chem. Int. Ed. 2015, 54, 9456.
Yao, W.; Dou, X.; Lu, Y. “Highly Enantioselective Synthesis of 3,4-Dihydropyrans through a Phosphine-Catalyzed [4 + 2] Annulation of Allenones and b,g-Unsaturated a-Keto Esters”, J. Am. Chem. Soc. 2015, 137, 54 (highlighted in SYNFACTS 2015, 201).
Jiang, C.; Lu, Y.; Hayashi, T. “High Performance of a Palladium-Phosphinooxazoline Catalyst in Asymmetric Arylation of Cyclic N-Sulfonyl Ketimines”, Angew. Chem. Int. Ed. 2014, 53, 9936 (highlighted in SYNFACTS 2014, 1203).
Han, X.; Yao, W.; Wang, T.; Tan, Y. R.; Yan, Z.; Kwistkowski, J.; Lu, Y. “Asymmetric Synthesis of Spiropyrazolones via Phosphine-Catalyzed [4+1] Annulations”, Angew. Chem. Int. Ed. 2014, 53, 5643.
Wang, T.; Yao, W.; Zhong, F.; Pang, G. H.; Lu, Y. “Phosphine Catalyzed Enantioselective g-Addition of 3-Substituted Oxindoles to 2,3-Butadienoates and 2-Butynoates: Use of Prochiral Nucleophiles”, Angew. Chem. Int. Ed. 2014, 53, 2964.
Zhong, F.; Dou, X.; Han, X.; Yao, W.; Zhu, Q.; Meng, Y.; Lu, Y. “Chiral Phosphine-Catalyzed Asymmetric Michael Addition of Oxindoles”, Angew. Chem. Int. Ed. 2013, 52, 943 (highlighted in SYNFACTS 2013, 216).
Zhong, F.; Luo, J.; Chen, G.-Y.; Dou, X.; Lu, Y. “Highly enantioselective regiodivergent allylic alkylation of MBH carbonates with phthalides”, J. Am. Chem. Soc. 2012, 134, 10222 (highlighted in SYNFACTS 2012, 906).
Han, X.; Zhong, F.; Wang, Y.; Lu, Y. “Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”, Angew. Chem. Int. Ed. 2012, 51, 767.
Zhong, F.; Han, X.; Wang, Y.; Lu, Y. “Highly Enantioselective [3 + 2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindole having Two Contiguous Quaternary Centers”, Angew. Chem. Int. Ed. 2011, 50, 7837 (highlighted in SYNFACTS 2011, 1020; one of the most cited Angew. Chem. Communications published in 2011/2012).
Han, X.; Wang, Y.; Zhong, F.; Lu, Y. “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-derived Novel Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”, J. Am. Chem. Soc. 2011, 133, 1726. (No. 1 JACS most-read article in January/February 2011; highlighted in SYNFACTS 2011, 442, highlighted by Organic Chemistry Portal; link: http://www.organic-chemistry.org/Highlights/2011/12December.shtm).
Luo, J.; Wang, H.; Han, X.; Xu, L.-W.; Kwiatkowski, J.; Huang, K.-W.; Lu, Y. “The Direct Asymmetric Vinylogous Aldol Reaction of Furanones with a-Ketoesters: Access to Chiral g-butenolides and Glycerol Derivatives”, Angew. Chem. Int. Ed. 2011, 50, 1861. (highlighted in SYNFACTS 2011, 445).
Zhu, Q.; Lu, Y. “Stereocontrolled Creation of All-Carbon Quaternary Stereocenters by Organocatalytic Conjugate Addition of Oxindoles to Vinyl Sulfone”, Angew. Chem. Int. Ed. 2010, 49, 7753. (highlighted in SYNFACTS 2010, 1305).
Han, X.; Kwiatkowski, J.; Xue, F.; Huang, K.-W.; Lu, Y. “Asymmetric Mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst”, Angew. Chem. Int. Ed. 2009, 48, 7604. (highlighted in SYNFACTS 2010, 102).