Publications

Primary, peer-reviewed research articles. (Reverse chronological)

  1. Seow WJ, Yanwen DL, Pan WC, Gunther SH, Sim X, Torta F, Herr DR, Kovalik JP, Jianhong C, Khoo CM, Wenk MR, Tai ES, van Dam RM. Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population. Mol Nutr Food Res. 2020 Oct 29:e2000527. doi: 10.1002/mnfr.202000527. Online ahead of print. [Pubmed]
  2. Chua XY, Chai YL, Chew WS, Chong JR, Ang HL, Xiang P, Camara K, Howell AR, Torta F, Wenk MR, Hilal S, Venketasubramanian N, Chen CP, Herr DR‡, Lai MKP‡. Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment. Alzheimer’s Research & Therapy. 2020 Sep 30;12(1):122. doi: 10.1186/s13195-020-00694-3. [Open access at BMC] [Pubmed]
  3. Seah JYH, Chew WS, Torta F, Khoo CM, Wenk MR, Herr DR, Choi H, Tai ES, van Dam RM. Plasma sphingolipids and risk of cardiovascular diseases: a large-scale lipidomic analysis. Metabolomics. 2020 Aug 20;16(9):89. doi: 10.1007/s11306-020-01709-8. [Pubmed]
  4. Wang W, Shanmugam MK, Xiang P, Yam TYA, Kumar V, Chew WS, Chang JK, Ali MZB, Reolo MJY, Peh YX, Karim SNBA, Tan AYY, Sanda T, Sethi G‡, Herr DR‡. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment. Cancers (Basel). 2020 Jan 15;12(1). pii: E211. doi: 10.3390/cancers12010211. [Open access at Cancers] [Pubmed]
  5. Herr DR‡, Yam TYA, Tan WSD, Koh SS, Wong WSF, Ong WY, Chayaburakul K‡. Ultrastructural Characteristics of DHA-Induced Pyroptosis. Neuromolecular Medicine. 2020 Jan 4. doi: 10.1007/s12017-019-08586-y. [Open access at NMM] [Pubmed]
  6. Wang W, Xiang P, Chew WS, Torta F, Bandla A, Lopez V, Seow WL, Lam BWS, Chang JK, Wong P, Chayaburakul K, Ong WY, Wenk MR, Sundar R‡, Herr DR‡. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. J Biol Chem. 2019 Dec 27. pii: jbc.RA119.011699. doi: 10.1074/jbc.RA119.011699. [Open access at JBC] [Pubmed]
  7. Chai JF, Raichur S, Khor IW, Torta F, Chew WS, Herr DR, Ching JH, Kovalik JP, Khoo CM, Wenk MR, Tai ES, Sim X. Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer’s and Parkinson’s diseases. Hum Mol Genet. 2019 Oct 19. pii: ddz246. doi: 10.1093/hmg/ddz246.
  8. Wee Siong Chew, Federico Torta, Shanshan Ji, Hyung Won Choi, Xueling Sim, Chin Meng Khoo, Eric Yin Hao Khoo, Wei Yi Ong, Rob Martinus Van Dam, Markus R. Wenk‡, E. Shyong Tai‡, Deron R. Herr‡. Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence. JCI Insight. 2019 Jun 4;5. pii: 126925. doi: 10.1172/jci.insight.126925. [Open access at JCI Insight] [PubMed]
  9. Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, Eliassen AH, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CM, Kivimäki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathé E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJ, Sesso HD, Shah SH, Shu XO, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W, Moore SC. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology. 2019 Jun 1;188(6):991-1012. doi: 10.1093/aje/kwz028. IF = 4.322. [PubMed]
  10. Wei Wang, Tatsuma Hind, Brenda Wan Shing Lam, and Deron R. Herr‡. Sphingosine 1-phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells. FASEB J. 2019 Mar 7:fj201801635R. doi: 10.1096/fj.201801635R. [PubMed]
  11. Srikanth M, Chew WS, Hind T, Lim SM, Hay NWJ, Lee JHM, Rivera R, Chun J, Ong WY, Herr DR‡. Lysophosphatidic acid and its receptor LPA1mediate carrageenan induced inflammatory pain in mice. Eur J Pharmacol. 2018 Oct 12. pii: S0014-2999(18)30582-X. doi: 10.1016/j.ejphar.2018.10.005. [PubMed]
  12. Srikanth M, Chandrasaharan K, Zhao X, Chayaburakul K, Ong WY, Herr DR‡. Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells. Neuromolecular Med. 2018 Sep 19. doi: 10.1007/s12017-018-8511-0. [PubMed]
  13. Heng HL, Chee CF, Thy CK, Tee JT, Chin SP, Herr DR, Buckle MJC, Paterson IC, Doughty SW, Abd Rahman N, Chung LY. In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2and α1 Chemical Biology and Drug Design. 2018 Sep 14. doi: 10.1111/cbdd.13390. IF = 2.328. [PubMed]
  14. Shao YM, Ma X, Paira P, Tan A, Herr DR, Lim KL, Ng CH, Venkatesan G, Klotz KN, Federico S, Spalluto G, Cheong SL, Chen YZ, Pastorin G. Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson’s disease treatment. PLoS One. 2018 Jan 5;13(1):e0188212. [PubMed]
  15. Heng, H.L., Chee, C.F., Chin, S.P., Ouyang, Y., Wang, H., Buckle, M.J.C., Herr, D.R., Paterson, I.C., Doughty, S.W., Abd Rahman, N., Chung, L.Y. Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists. MedChemComm. Volume 9, Issue 3, 2018, Pages 576-582.
  16. Ho CF, Bon CP, Ng YK, Herr DR, Wu JS, Lin TN, Ong WY. Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochem Res. 2017 Dec 12. [PubMed]
  17. Thirunavukkarasan M, Wang C, Rao A, Hind T, Teo YR, Siddiquee AA, Goghari MAI, Kumar AP, Herr DR‡. Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. PLoS One. 2017 Oct 19;12(10):e0186334. [PubMed] [Full text, open access]
  18. Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY. Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Mol Neurobiol. 2017 Oct 17. [PubMed]
  19. Rao A, Herr DR‡ . G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. BBA Molecular Cell Research. 2017 Jul;1864(7):1318-1327. Epub 2017 May 2. [PubMed] [Full text, open access]
  20. Shalini SM, Ho CF, Ng YK, Tong JX, Ong ES, Herr DR, Dawe GS, Ong WY. Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory. Molecular Neurobiology. 2017 Feb 8. [PubMed]
  21. Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY. Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline. Neuroscience. 2016 Oct 24;340:91-100. doi: 10.1016/j.neuroscience.2016.10.037. [PubMed]
  22. Shalini SM, Herr DR, Ong WY. The Analgesic and Anxiolytic Effect of Souvenaid, a Novel Nutraceutical, Is Mediated by Alox15 Activity in the Prefrontal Cortex. Molecular Neurobiology. 2017 Oct; 54(8):6032-6045. [PubMed]
  23. Wong SY, Tan MG, Wong PT, Herr DR, Lai MK. (2016) Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK. J Neuroinflammation. 2016 Sep 23;13(1):251. [PubMed]
  24. Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. (2016) Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity. Peptides. 2016 Aug 3. pii: S0196-9781(16)30146. [PubMed]
  25. Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B.Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. J Am Heart Assoc. 2016 May 20;5(5). pii: e003393. doi: 10.1161/JAHA.116.003393. [PubMed] [Full text, open access]
  26. Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC. (2016) Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Nature Scientific Reports. 2016 May 10;6:25650. doi: 10.1038/srep25650. [PubMed]
  27. Deron R. Herr‡, Marie J. Y. Reolo, Peh Yee Xin, Wei Wang, Chang-Wook Lee, Rich Rivera, Ian C. Paterson, Jerold Chun. (2016) Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Nature Scientific Reports. 2016 Apr 15;6:24541. doi: 10.1038/srep24541. [PubMed] [Full text, open access]
  28. Korpi ER, Linden AM, Hytönen HR, Paasikoski N, Vashchinkina E, Dudek M, Herr DR, Hyytiä P. (2016) Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors. Addiction Biology. 2016 Mar 15. doi: 10.1111/adb.12393. [PubMed]
  29. Yang Y, Torta F, Arai K, Wenk MR, Herr DR, Wong PT, Lai MK. (2016) Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. Neurochemistry International. 2016 Mar;94:90-7. doi: 10.1016/j.neuint.2016.02.012. [PubMed]
  30. Godfrey J, Jeanguenin L, Castro N, Olney JJ, Dudley J, Pipkin J, Walls SM, Wang W, Herr DR, Harris GL, Brasser SM. (2015) Chronic Voluntary Ethanol Consumption Induces Favorable Ceramide Profiles in Selectively Bred Alcohol-Preferring (P) Rats. PLoS One. 2015 Sep 25;10(9):e0139012. [PubMed]
  31. Ratliff EP, Mauntz RE, Kotzebue RW, Gonzalez A, Achal M, Barekat A, Finley KA, Sparhawk JM, Robinson JE, Herr DR, Harris GL, Joiner WJ, Finley KD. (2015) Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS One. 2015 Jul 16;10(7):e0132768. [PubMed]
  32. Walls SM Jr, Attle SJ, Brulte GB, Walls ML, Finley KD, Chatfield DA, Herr DR, Harris GL. (2013) Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila. PLoS Genetics. 2013 Dec;9(12):e1003970. [PubMed]
  33. Herr DR, Lee CW, Wang W, Ware A, Rivera R, Chun J. (2013) Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. Journal of Biological Chemistry. 2013 Oct 11;288(41):29882-9. [PubMed] [Full text, open access]

Peer-reviewed review articles. (Reverse chronological)

  1. Chua XY, Ho LTY, Xiang P, Chew WS, Lam BWS, Chen CP, Ong WY, Lai MKP‡, Herr DR‡. Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromolecular Med. 2020 Nov 12. doi: 10.1007/s12017-020-08632-0. [Open access text] [PubMed] [Publisher]
  2. Ong WY‡, Stohler CS, Herr DR‡. Role of the Prefrontal Cortex in Pain Processing. Mol Neurobiol. 2018 Jun 6. [PubMed] [Full text, open access]
  3. Chew WS, Seow WL, Chong JR, Lai MKP, Torta F, Wenk MR, Herr DR‡. Sphingolipidomics analysis of large clinical cohorts. Part 1: Technical notes and practical considerations. (Invited Review.) Biochem Biophys Res Commun. 2018 Apr 11. [PubMed] [Publisher]
  4. Chong JR, Xiang P, Wang W, Hind T, Chew WS, Ong WY, Lai MKP, Herr DR‡. Sphingolipidomics analysis of large clinical cohorts. Part 2: Potential impact and applications. (Invited Review.) Biochem Biophys Res Commun. 2018 Apr 11. [PubMed] [Publisher]
  5. Herr DR‡, Ong JH, Ong WY. Potential Therapeutic Applications for Inhibitors of Autotaxin, a Bioactive Lipid-Producing Lysophospholipase D, in Disorders Affecting the Nervous System. ACS Chem Neurosci. 2018 Mar 21;9(3):398-400. [PubMed] [Full text, open access]
  6. Patmanathan SN, Wang W, Yap LF, Herr DR, Paterson IC. Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. Cellular Signalling. 2017 Mar 13. pii: S0898-6568(17)30071-2. [PubMed]
  7. Chew WS, Wang W, Herr DR‡. (2016) To fingolimod and beyond: the rich pipeline of drug candidates that target S1P signaling. (Invited Review.) Pharmacol Res. 2016 Sep 20. pii: S1043-6618(16)30877-5. doi: 10.1016/j.phrs.2016.09.025. [PubMed] [Publisher]
  8. Lai MK, Chew WS, Torta F, Rao A, Harris GL, Chun J, Herr DR‡. (2016) Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs. (Invited Review.) Neuromolecular Med. 2016 Jul 8. [PubMed] [Publisher]
  9. Ong WY, Herr DR, Farooqui T, Ling EA, Farooqui AA. (2015) Role of sphingomyelinases in neurological disorders. Expert Opin Ther Targets. 2015 Aug 4:1-18. [PubMed]
  10. Herr DR‡. (2012) Potential use of G protein-coupled receptor-blocking monoclonal antibodies as therapeutic agents for cancers. (Invited Review.) International Review of Cell & Molecular Biology. 297:45-81. [PubMed] [Publisher]

Book Chapters.

  1. Autophagy in Health and Disease. (2012) Deron Herr & Kim D. Finley, Molecular Machinery and Genetics of the Autophagy Pathway. Chapter 2, pg.11-30. Roberta Gottlieb, Editor, Elsevier Inc. Copyright © 2013. ISBN:978-0-12-386101-7.

DRH lab members

* Authors contributed equally.

‡ Corresponding author.