Undergraduate Studies: BEng (Hons) Chemical and Process Engineering (2000), University of Newcastle Upon Tyne, UK
Masters: MSc in Process Systems Engineering, Diploma of Imperial College (2001), Imperial College of Science, Medicine and Technology, London
M. Eng. in Chemical and Biomolecular Engineering, National University of Singapore (2007)
Contact Engineer, ExxonMobil Chemical (2002)
Process Engineer, Singapore Refining Company (2003)
Research Intern, Animal Cell Culture and Bioreactors, Bioprocessing Technology Institute, Singapore (2004)
The controlled release of chemotherapeutic agents holds promise for treatments of solid tumors by prolonged cytotoxicity to tumor cells while minimizing chemotherapeutic associated side effects in patients. Often, such drug delivery systems allow the use of potential drugs with low therapeutic indexes previously administered only by continuous IV.
My work looks at optimizing the efficacy of controlled release treatment into tumors within the brain through in vivo animal models as well as computational modeling of the extravasation of drug into the tumor mass. Of special interest is the complimentary effect of irradiation on drug transport from implants (surgically inserted post tumor debulking surgery) within the brain.
Integration of process systems engineering into this problem is used to optimize the overall drug delivery system design using gams-Baron optimization complier
Previous research work at Imperial College involved modeling of supply chain dynamics in response to dynamic pricing and model predictive control forecasting.
P. K. Naraharisetti, B. Y. S. Ong, J. Xie, T. Lee, N. Sahinidis, C. H. Wang, Paclitaxel-loaded biodegradable discs and microspheres for treatment of Glioma: Subcutaneous study, Biometerials, 28, 886-894, 2007.
B.Y.S. Ong, S.H. Ranganath, LY Lee, F. Lu, H.S. Lee, N.V. Sahinidis, C.H. Wang, “Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme”, Biomaterials, 30, 3189-3196, 2009.