Publications

Cohort reference publications

[National Precision Medicine] Wong E et al. The Singapore National Precision Medicine Strategy. Nat Genet. 2023 Feb;55(2):178-186.

[CHS_T1] Chan TK et al. Cancer Screening Knowledge and Behaviour in a Multi-Ethnic Asian Population: The Singapore Community Health Study. Front Oncol. 2021 Aug 12;11:684917.

[MEC2_T1] Whitton C et al. Longitudinal Associations of Marital, Parenting, and Employment Transitions with Weight Gain in a Multi-Ethnic Asian Population Aged 21 Years and Above. Int J Environ Res Public Health. 2021 Jul 31;18(15):8115.

[DC_T1] Luo M et al. Cohort profile: the Singapore diabetic cohort study. BMJ Open 2020;10:e036443.

[MEC1_T1] Tan KHX et al. Cohort Profile: The Singapore Multi-Ethnic Cohort (MEC) study. Int J Epidemiol. 2018 Jun 1;47(3):699-699j.

[SH2_T1] Vaingankar J et al. Psychometric properties and population norms of the Positive Mental Health instrument in a representative multi-ethnic Asian population. BMC Med Res Methodol. 2018 Mar 15;18(1):29.

[SH2012_T1] Win AM et al. Patterns of physical activity and sedentary behavior in a representative sample of a multi-ethnic South-East Asian population: a cross-sectional study. BMC Public Health. 2015 Apr 1;15:318.

All publications

2024

267. Chia A et al. Complexity of consumer acceptance to alternative protein foods in a multiethnic Asian population: A comparison of plant-based meat alternatives, cultured meat, and insect-based products, Food Quality and Preference, Volume 114, May 2024.

266. Lee MY et al. Association between Marital Status and Cognitive Impairment in a Multi-Ethnic Asian Population. Neuroepidemiology. 2024 Mar 14.

265. Guirette M et al. Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. Hypertension. 2024 Mar;81(3):552-560.

264. Suzuki K et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024 Feb 19.

263. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024 Feb 29:S0140-6736(23)02750-2.

262. Scholz M et al. X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nat Commun. 2024 Jan 18;15(1):586.

2023

261. Lim SX et al. Development and validation of a lifestyle risk index to screen for metabolic syndrome and its components in two multi-ethnic cohorts. Prev Med. 2023 Dec 18:107821

260. Feng Z et al. Associations of childhood and current secondhand smoke exposure at home with current secondhand smoke exposure at work: A cross-sectional analysis of the Singapore multi-ethnic cohort. Tob Induc Dis. 2023 Dec 15;21:169.

259. Chan CMJ et al. Understanding knowledge, attitudes and behaviours related to dietary sodium intake in a multi-ethnic population in Singapore. Public Health Nutr. 2023 Dec;26(12):2802-2814.

258. Huang J et al. Association of diet quality with hand grip strength weakness and asymmetry in a multi-ethnic Asian cohort. Br J Nutr. 2023 Nov 22:1-8

257. de Las Fuentes L et al. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Front Genet. 2023 Nov 2;14:1235337.

256. Lim CGY et al. RECALIBRATED SINGAPORE-MODIFIED FRAMINGHAM RISK SCORE 2023 (SG-FRS-2023). [Report]

255. Ang IYH et al. Preferences and willingness-to-pay for a blood pressure telemonitoring program using a discrete choice experiment. NPJ Digit Med. 2023 Sep 25;6(1):176.

254. Seah JYH et al. Risk prediction models for type 2 diabetes using either fasting plasma glucose or HbA1c in Chinese, Malay, and Indians: Results from three multi-ethnic Singapore cohorts. Diabetes Res Clin Pract. 2023 Aug 15;203:110878.

253. Park SH et al. Acculturation as a Determinant of Obesity and Related Lifestyle Behaviors in a Multi-Ethnic Asian Population. Nutrients. 2023 Aug 17;15(16):3619.

252. Seah JYH et al. Differences in type 2 diabetes risk between East, South, and Southeast Asians living in Singapore: the multi-ethnic cohort. BMJ Open Diabetes Res Care. 2023 Jul;11(4):e003385.

251. Ge L et al. Association Between Domain-Specific Physical Activity and Cardiometabolic Factors in a Multiethnic Asian Population: A Longitudinal Study. J Phys Act Health. 2023 May 8:1-14.

250. Xu Y et al. An atlas of genetic scores to predict multi-omic traits. Nature. 2023 Apr;616(7955):123-131.

249. Huang X et al. Association between nutrition and cognition in a multi-ethnic cohort from Singapore. Eur J Nutr. 2023 Apr 27.

248. Lee et al. Isocaloric substitution of plant-based protein for animal-based protein and cardiometabolic risk factors in a multi-ethnic Asian Population. J Nutr. 2023 Mar 22.

247. Goh AT et al. Associations between oral processing, saliva, and bolus properties on daily glucose excursions amongst people at risk of type-2 diabetes. Food Funct. 2023 Feb 21;14(4):2260-2269.

246. Wong E et al. The Singapore National Precision Medicine Strategy. Nat Genet. 2023 Feb;55(2):178-186.

245. Rooney MR et al. Proteomic Predictors of Incident Diabetes: Results From the Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. 2023 Jan 27:dc221830.

244. Diocom AR et al. Association between Shift Work Schedules and Cardiovascular Events in a Multi-Ethnic Cohort. Int J Environ Res Public Health. 2023 Jan 22;20(3):2047.

2022

243. Yin X et al. Dietary factors and the risk of lung cancer by epidermal growth factor receptor mutation status and histological subtypes. Front Public Health. 2022 Dec 2;10:1079543.

242. Wang LY et al. Factors Associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the Association of These Biomarkers with Cardiovascular Disease in a Multi-Ethnic Population. J Clin Med. 2022 Dec 8;11(24):7281.

241. Kanoni S et al. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol. 2022 Dec 27;23(1):268.

240. Zhong S et al. Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans. J Clin Invest. 2022 Nov 1;132(21):e152961.

239. Feng Z et al. Determinants of Hardcore Smoking in a MULTI-ETHNIC Study of Cigarette Smokers in Singapore. J Psychoactive Drugs. 2022 Nov 14:1-11.

238. Chan et al. Analysis of clinically relevant variants from ancestrally diverse Asian genomes. Nat Commun. 2022 Nov 5;13(1):6694.

237. Yengo L et al. A saturated map of common genetic variants associated with human height. Nature. 2022 Oct;610(7933):704-712.

236. JS Gounot et al. Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians. Nat Commun. 2022 Oct 13;13(1):6044

235. Wang et al. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nat Genet. 2022 Sep;54(9):1332-1344.

234. Lee et al. Dietary patterns and predicted 10-year cardiovascular disease risk in a multiethnic Asian population. Nutr Metab Cardiovasc Dis. 2022 Sep;32(9):2093-2104.

233. Ramdas et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet. 2022 Aug 4;109(8):1366-1387.

232. Betzler et al. Impact of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) GFR Estimating Equations on CKD Prevalence and Classification Among Asians. Front Med (Lausanne). 2022 Jul 14;9:957437.

231. Winkler et al. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Commun Biol. 2022 Jun 13;5(1):580.

230. Voo TC et al. Public acceptability of COVID-19 control measures in Singapore, Hong Kong, and Malaysia: A cross-sectional survey. Int J Infect Dis. 2022 Jul;120:51-58.

229. Seah JYH et al. Circulating Metabolic Biomarkers Are Consistently Associated With Type 2 Diabetes Risk in Asian and European Populations. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e2751-e2761

228. Low A et al. Mutual exclusion of Methanobrevibacter species in the human gut microbiota facilitates directed cultivation of a Candidatus Methanobrevibacter intestini representative. Microbiol Spectr. 2022 Jun 14;e0084922.

227. Edney SM et al. Advancing understanding of dietary and movement behaviours in an Asian population through real-time monitoring: Protocol of the Continuous Observations of Behavioural Risk Factors in Asia study (COBRA). Digit Health, 2022 Jun 30

226. Boey et al. Secondhand smoke in the densely populated urban setting: A cross-sectional survey of exposure, knowledge, attitudes, and respiratory symptoms. Indoor Air. 2022 Jun;32(6):e13069.

225. Petrunoff N et al. Associations of park features with park use and park-based physical activity in an urban environment in Asia: A cross-sectional study. Health & Place, Volume 75, May 2022, 102790

224. Ng PS et al. Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore. J Med Genet. 2022.

223. Lu et al. A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. Eur Heart J. 2022 May 7;43(18):1702-1711.

222. Dorling et al. Breast cancer risks associated with missense variants in breast cancer susceptibility genes. Genome Med. 2022 May 18;14(1):51.

221. Peh JH et al. Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification. BMC Medicine volume 20, Article number: 150 (2022)

220. Park SH et al. Daily park use, physical activity, and psychological stress: A study using smartphone-based ecological momentary assessment amongst a multi-ethnic Asian cohort. Ment Health Phys Act. 2022;22:100440.

219. Lim CGY et al. Replacing dietary carbohydrates and refined grains with different alternatives and risk of cardiovascular diseases in a multi-ethnic Asian population. Am J Clin Nutr. 2022 Mar 4;115(3):854-863.

218. Breast Cancer Association Consortium. Pathology of Tumors Associated with Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes. JAMA Oncol. 2022 Mar 1;8(3):e216744.

217. Park SH et al. Diet and Physical Activity as Determinants of Continuously Measured Glucose Levels in Persons at High Risk of Type 2 Diabetes. Nutrients. 2022 Jan 15;14(2):366.

216. Lim JT et al. Impact of Subsidy on the Use of Personalized Medicine in Breast Cancer. Value Health Reg Issues. 2022 Jan 29;29:108-115.

2021

215. Hindy G et al. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2021 Dec 16:S0002-9297(21)00452-3.

214. Graham SE et al. The power of genetic diversity in genome-wide association studies of lipids. Nature 600, 675–679 (2021).

213. Clapham HE et al. Contrasting SARS-CoV-2 epidemics in Singapore: cohort studies in migrant workers and the general population. Int J Infect Dis. 2021 Dec 2;115:72-78.

212. Betzler BK et al. Association between Body Mass Index and Chronic Kidney Disease in Asian Populations: A Participant-level Meta-Analysis. 2021 Dec;154:46-54.

211. Peo PS et al. Taste of Modern Diets: The Impact of Food Processing on Nutrient Sensing and Dietary Energy Intake. J Nutr . 2021 Oct 12;nxab318.

210. Chen Y et al. Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals. Clin Epigenet 13, 195 (2021).

209. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021 Sep 11;398(10304):957-980.

208. Goyal S et al. APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups. Lipids Health Dis. 2021 Sep 21;20(1):113.

207. Goh AT et al. Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test. Eur J Nutr 2021 Aug;60(5):2719-2733

206. Ding Y et al. Comparative Genomic Analysis of Extended-spectrum β-lactamase and mcr-1 Positive Escherichia coli from Gut Microbiota of Healthy Singaporean. Appl Environ Microbiol. 2021 Aug 4;AEM0048821

205. Chan TK et al. Cancer Screening Knowledge and Behaviour in a Multi-Ethnic Asian Population: the Singapore Community Health Study. Front. Oncol. 12 August 2021

204. Whitton C et al. Longitudinal Associations of Marital, Parenting, and Employment Transitions with Weight Gain in a Multi-Ethnic Asian Population Aged 21 Years and Above. Int. J. Environ. Res. Public Health 2021, 18(15), 8115

203. Petrunoff NA et al. Associations of park access, park use and physical activity in parks with wellbeing in an Asian urban environment: a cross-sectional study. Int J Behav Nutr Phys Act. 2021 Jul 2;18(1):87

202. ven der Eijk et al. Cross-sectional survey of flavored cigarette use among adult smokers in Singapore. Tob Induc Dis. 2021 Jun 3;19:42.

201. JK Goodrich et al. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9;12(1):3505

200. J Chen et al. The trans-ancestral genomic architecture of glycemic traits. Nat Genet. 2021 Jun;53(6):840-860

199. Lim CGY et al. Diet Quality and Lower Refined Grain Consumption are Associated With Less Weight Gain in a Multi-Ethnic Asian Adult Population. J Nutr. 2021 May 12;nxab110

198. Ho PJ et al. Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers. PLoS One. 2021 Apr 26;16(4):e0250102.

197. NCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife. 2021 Mar 9;10:e60060

196. Seah JYH et al. Dietary Fat and Protein Intake in Relation to Plasma Sphingolipids as Determined by a Large-Scale Lipidomic Analysis. Metabolites. 2021 Feb 8;11(2):93

195. Kassam I et al. Genome-wide identification of cis DNA methylation quantitative trait loci in three Southeast Asian populations. Hum Mol Genet 2021 Feb 6;ddab038

194. Breast Cancer Association Consortium et al. Breast Cancer Risk Genes – Association Analysis in More than 113,000 Women. N Engl J Med. 2021 Feb 4;384(5):428-439

193. Park SH et al. Adaptation and Validation of a Short Acculturation Scale in a Multi-Ethnic Asian Population. Psych 2021, 3(1), 25-38

2020

192. Surendran P et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020 Dec;52(12):1314-1332.

191. Park SH et al. Ethnicity, Neighborhood and Individual Socioeconomic Status, and Obesity: The Singapore Multiethnic Cohort. Obesity (Silver Spring). 2020 Dec;28(12):2405-2413

190. Müller-Riemenschneider F et al. The Association of Different Types of Leisure Time Physical Activities with Cardiometabolic Outcomes in Singapore-Findings from the Multi-Ethnic Cohort Study. Int J Environ Res Public Health. 2020 Dec 3;17(23):9030

189. Vaingankar et al. Sleep duration, sleep quality and physical activity, but not sedentary behaviour, are associated with positive mental health in a multi-ethnic Asian. Int J Environ Res Public Health. 2020 Nov 16;17(22):8489

188. Teo PS et al. Consumption of Foods with Higher Energy Intake Rates is Associated with Greater Energy Intake, Adiposity, and Cardiovascular Risk Factors in Adults. J Nutr. 2020 Nov 26;nxaa344

187. Ying L et al. Development of a serum miRNA panel for detection of early stage non-small cell lung cancer. Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25036-25042

186. Teo PS, van Dam RM, Forde CG. Combined Impact of a Faster Self-Reported Eating Rate and Higher Dietary Energy Intake Rate on Energy Intake and Adiposity. Nutrients. 2020 Oct 25;12(11):3264

185. Seow WJ et al. Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population. Mol Nutr Food Res. 2020 Oct 29:e2000527

184. Gunther SH et al. Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population. BMJ Open Diabetes Res Care. 2020 Oct;8(1):e001315.

183. Lim JM. et al. Population anxiety and positive behaviour change during the COVID-19 epidemic: Cross-sectional surveys in Singapore, China and Italy. Influenza and Other Respiratory Viruses. 2020 Sep 05.

182. Chai JF et al. Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia. J Clin Endocrinol Metab. 2020 Sep 16:dgaa658.

181. Seah JYH et al. Plasma sphingolipids and risk of cardiovascular diseases: a large-scale lipidomic analysis. Metabolomics. 2020 Aug 20;16(9):89.

180. Gunther SH et al. Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population. Nutrients. 2020 Aug 27;12(9):E2603.

179. Ding Y et al. Emergence of Tigecycline- and Eravacycline-resistant Tet(X4)-producing Enterobacteriaceae in the gut microbiota of healthy Singaporeans. J Antimicrob Chemoth. 2020 Aug 27: dkaa372

178. Zheng Y et al. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. Eur J Epidemiol (2020)

177. Ho WK et al. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nat Commun. 2020 Jul 31;11(1):3833

176. Spracklen CN etal. Identification of Type 2 Diabetes Loci in 433,540 East Asian Individuals. Nature. 2020 Jun;582(7811):240-245.

175. NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the Global Epicentre of Non-Optimal Cholesterol. Nature. 2020 Jun;582(7810):73-77.

174. Jones M et al. Exploring Factors Underlying Ethnic Difference in Age-related Macular Degeneration Prevalence. Ophthalmic Epidemiol. 2020 Jun 8;1-10

173. Fuentes LDL et al. Gene-educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci. Mol Psychiatry. 2020 May 5.

172. Dou J et al. Using off-target data from whole-exome sequencing to improve genotyping accuracy, association analysis and polygenic risk prediction. Brief Bioinform. 2020 Jun 17:bbaa084.

171. Luo M et al. Cohort profile: the Singapore diabetic cohort study. BMJ Open 2020;10:e036443.

170. Vaingankar et al. Development and validation of the Rapid Positive Mental Health Instrument (R-PMHI) for measuring mental health outcomes in the population. BMC Public Health. 20, 471 (2020)

169. Teo PS et al. Association between self-reported eating rate, energy intake, and cardiovascular risk factors in a multi-ethnic Asian population. Nutrients 2020, 12(4), 1080

168. Zheng FH et al. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia. Acta Ophthalmol. 2020 Jun 29.

167. Lee JK et al. Social Capital and Health Communication in Singapore: An Examination of the Relationships between Community Participation, Perceived Neighborliness and Health Communication Behaviors. J Health Commun. 00: 1–10, 2020

166. Ding Q et al. Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. J Hum Genet. 2020 Apr;65(4):411-420.

165. Leong A et al. Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals. BMJ Open Diabetes Res Care. 2020 Mar;8(1). pii: e001091

164. Chu AHY et al. Accelerometer Profile of Physical Activity and Sedentary Behavior in a Multi-Ethnic Urban Asian Population. Res Q Exerc Sport. 2020 Mar 10:1-8

163. Sumner J et al. Volume and Intensity of Stepping Activity and Cardiometabolic Risk Factors in a Multi-ethnic Asian Population. Int J Environ Res Public Health. 2020 Jan 30;17(3). pii: E863

2019

162. Cheong KW etal. Sun Exposure and Sun Safety Habits Among Adults in Singapore: A Cross-Sectional Study. Ann Acad Med Singapore. 2019 Dec;48(12):412-428.

161. Clark D et al. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 2019 Oct 31;10(1):4957.

160. Chai JF et al. Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer’s and Parkinson’s diseases. Hum Mol Genet. 2019 Oct 19.

159. Teumer A et al. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nat Commun. 2019 Sep 11;10(1):4130

158. Lim CGY and van Dam RM. Attitudes and beliefs regarding food in a multi-ethnic Asian population and their association with socio-demographic variables and healthy eating intentions. Appetite. 2019 Sep 17;144:104461.

157. BIRTH-GENE (BIG) Study Working Group et al. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study. JAMA Netw Open. 2019 Sep 4;2(9):e1910915

156. Wuttke M et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet. 2019 Jun;51(6):957-972

155. Müller AM et al. Associations between psychological factors and accelerometer-measured physical activity in urban Asian adults. Int J Public Health. 2019 Jun;64(5):659-668.

154. Flannick J et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun;570(7759):71-76

153. Hoong JSY et al. Plasma Sphingolipids and Subclinical Atherosclerosis – Novel Associations Uncovered by a Large-scale Lipidomic Analysis (P18-129-19). Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz039.P18-129-19.

152. de Vries PS et al. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Am J Epidemiol. 2019 Jun 1;188(6):1033-1054

151. Chew WS et al. Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence. JCI Insight. 2019 Jun 4;5. pii: 126925.

150. Liew SJ et al. Sociodemographic factors in relation to hypertension prevalence, awareness, treatment and control in a multi-ethnic Asian population: a cross-sectional study. BMJ Open. 2019 May 19;9(5):e025869.

149. Ho VWT et al. Cumulative Effect of Visual Impairment, Multimorbidity, and Frailty on Intrinsic Capacity in Community-Dwelling Older Adults. J Aging Health. 2019 May 8:898264319847818.

148. Sung YJ et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Apr 10. pii: ddz070.

147. Bentley AR et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 Apr;51(4):636-648

146. Saw SM et al. Prevention and Management of Myopia and Myopic Pathology. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):488-499

145. Luo M et al. Association of diabetes treatment with long-term glycemic patterns in patients with type 2 diabetes mellitus: A prospective cohort study. Diabetes Metab Res Rev. 2019 Jan 2:e3122.

144. Kilpeläinen TO et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. 2019 Jan 22;10(1):376.

2018

143. Takeuchi F et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nat Commun. 2018 Nov 28;9(1):5052

142. Merchant RA et al. Vitamin D Binding Protein and Vitamin D Levels in Multi-Ethnic Population. J Nutr Health Aging. 2018;22(9):1060-1065.

141. van Zuydam NR et al. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1414-1427

140. Feitosa MF et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018; 13(6): e0198166.

139. Yap P et al. Prevalence of and risk factors associated with latent tuberculosis in Singapore: a cross-sectional survey. Int J Infect Dis. 2018 May 11. pii: S1201-9712(18)34412-6

138. Whitton C et al. A Healthy Asian A Posteriori Dietary Pattern Correlates with A Priori Dietary Patterns and Is Associated with Cardiovascular Disease Risk Factors in a Multiethnic Asian Population. J Nutr. 2018 Apr 1;148(4):616-623.

137. Sumner J et al. Stepping volume and intensity patterns in a multi-ethnic urban Asian population. BMC Public Health. 2018 Apr 23;18(1):539.

136. Khaing EE et al. Epicardial and visceral adipose tissue in relation to subclinical atherosclerosis in a Chinese population. PLoS One. 2018 Apr 25;13(4):e0196328

135. Hou Y et al. Adequacy of public health communications on H7N9 and MERS in Singapore: insights from a community based cross-sectional study. BMC Public Health. Apr 2018; 18:436

134. Chu AHY et al. Self-reported domain-specific and accelerometer-based physical activity and sedentary behaviour in relation to psychological distress among an urban Asian population. Int J Behav Nutr Phys Act. 2018; 15:36

133. Vaingankar J et al. Psychometric properties and population norms of the Positive Mental Health instrument in a representative multi-ethnic Asian population. BMC Med Res Methodol. (2018) 18:29

132. Tan KHX et al. Cohort Profile: The Singapore Multi-Ethnic Cohort (MEC) study. Int J Epidemiol. 2018 Feb 13

131. Sung YJ et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400.

130. Chang X et al. Gene-diet interaction effects on BMI levels in the Singapore Chinese population. Nutr J. 2018 Feb 24;17(1):31.

2017

129. Uijtdewilligen et al. Correlates of occupational, leisure and total sitting time in working adults: results from the Singapore multi-ethnic cohort. Int J Behav Nutr Phys Act. 2017; 14: 169

128. Tan A et al. Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population. Sleep Breath. 2017 Dec;21(4):1033-1038.

127. Han Y et al. Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. Sci Rep. 2017 Dec 20;7(1):17921.

126. Jiang L et al. Comparison of self-reported contacts between hospital-based healthcare workers and working adults from the general population and its implications for infectious disease transmission. J Hosp Infect. 2017 Oct 30. pii: S0195-6701(17)30587-X.

125. Saw WY et al. Establishing multiple omics baselines for three Southeast Asian ethnic groups in the Singapore Integrative Omics Cohort. Nat Comm. 2017 Sep 21; 8:653

124. Goh EH et al. Epidemiology and relative severity of influenza subtypes in Singapore in the post-pandemic period from 2009 to 2010. Clin Infect Dis. 2017 Sep 23.

123. Sia CH et al. Awareness and knowledge of obstructive sleep apnea in the general population. Sleep Med. Aug 2017; 36:10-17

122. Merchant R et al. Singapore Healthy Older People Everyday (HOPE) Study: Prevalence of Frailty and Associated Factors in Older Adults. J Am Med Dir Assoc. 2017 Jun 13

121. Luo Ma et al. Longitudinal trends in HbA1c and associations with comorbidity and all-cause mortality in Asian patients with type 2 diabetes: A cohort study. Diabetes Res Clin Pract. 2017 Aug 24;133:69-77.

120. Spracklen CN et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017 May 1;26(9):1770-1784

119. Han MR et al. Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians. Carcinogenesis. 2017 May 1;38(5):511-518

118. Li C et al. Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians. Circ Cardiovasc Genet. 2017 Apr;10(2):e001527.

117. Shimelis H et al. BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. 2017 Mar 10.

116. Jiang L et al. Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore. Sci Rep. 2017 Feb 20;7:42963.

115. Springelkamp H et al. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum Mol Genet. 2017 Jan 10. pii: ddw399.

114. Khoo NKH et al. Comparative seroepidemiology of genital human papillomavirus infections in the general population in Singapore. Public Health 2017;142: 1-3.

2016

113. Wen W et al. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Res. 2016 Dec 8;18(1):124

112. Venkataraman K et al. Determinants of individuals’ participation in integrated chronic disease screening in Singapore. J Epidemiol Community Health. 2016 Dec;70(12):1242-1250.

111. Tan A et al. Using Berlin Questionnaire to Predict Obstructive Sleep Apnea in the General Population. J Clin Sleep Med. 2016 Nov 14

110. Liu J et al. rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk. Sci Rep. 2016 Nov 15;6:36874

109. Tan A et al. Predicting obstructive sleep apnea using the STOP-Bang questionnaire in the general population. Sleep Med. 2016 Oct; 27(10): 66-71

108. Ghoussaini M et al. Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. Am J Hum Genet. 2016 Oct 6;99(4):903-911

107. Wyszynski A et al. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet. 2016 Sep 1;25(17):3863-3876

106. Shi J et al. 6. Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int J Cancer.2016 Sep15; 139(6):1303-17

105. Lawrenson K et al. 7. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Comm. 2016 Sep 7;7:12675

104. Darabi H et al. 8. Fine scale mapping of the 17q22 breast cancer locus using de nse SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). Sci Rep. 2016 Sep 7;6:32512

103. Horne HN et al. Fine-mapping of the 1p11.2 breast cancer susceptibility locus. PLoS One. 2016 Aug 24;11(8):e0160316

102. NCD Risk Factor Collaboration (NCD-RisC). A century of trends in adult human height. eLife. 2016; 5: e13410.

101. Fuchsberger C. et al. The genetic architecture of type 2 diabetes. Nature. 2016 Jul 11

100. Zeng C et al. Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res. 2016 Jun 21;18(1):64

99. Whitton C et al. Evaluation of Equations for Predicting 24-Hour Urinary Sodium Excretion from Casual Urine Samples in Asian Adults. J Nutr. 2016 Jun 29. pii: jn232108.

98. Cima I et al. Tumor-derived circulating endothelial cell clusters in colorectal cancer. Sci Transl Med. 2016 Jun 29;8(345):345ra89.

97. Zhao Z et al. Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control. 2016 Apr 6.

96. Dunning AM et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016 Apr;48(4):374-86.

95. Tan A et al. Prevalence of Sleep-Disordered Breathing in a Multiethnic Asian Population in Singapore: a Community-Based Study. Respirology. 2016 Feb 29.

94. Horikoshi M et al. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet. 2016 Feb 23. pii: ddw048.

93. Easton DF et al. No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. J Med Genet. 2016 Feb 26. pii: jmedgenet-2015-103529.

92. Wen W et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20;6:17958

91. Begum H et al. Discovering and validating between-subject variations in plasma lipids in healthy subjects. Sci Rep. 2016 Jan 8;6:19139

2015

90. Koh HW et al. The Pittsburgh Sleep Quality Index in a multi-ethnic Asian population contains a three-factor structure. Sleep Breath. 2015 Dec;19(4):1147-54

89. Tan NC et al. 5-Year longitudinal study of determinants of glycemic control for multi-ethnic Asian patients with type 2 diabetes mellitus managed in primary care. Diabetes Res Clin Pract. 2015 Nov;110(2):218-23

88. Kato N et al. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov;47(11):1282-93.
87. Guo X et al. Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1680-91.

86. Nang EEK et al. Association of Television Viewing Time with Body Composition and Calcified Subclinical Atherosclerosis in Singapore Chinese. Maeda N, ed. PLoS ONE. 2015;10(7):e0132161.

85. Lim RB et a. Anthropometrics indices of obesity, and all-cause and cardiovascular disease-related mortality, in an Asian cohort with type 2 diabetes mellitus. Diabetes Metab. 2015 Sep;41(4):291-300.

84. NCD Risk Factor Collaboration (NCD-RisC). Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants.. Lancet Diabetes Endocrinol. 2015 Aug;3(8):624-37

83. Lim CC et al. Chronic kidney disease, cardiovascular disease and mortality: A prospective cohort study in a multi-ethnic Asian population. Eur J Prev Cardiol. 2015 Aug;22(8):1018-26.

82. Darabi H et al. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. Am J Hum Genet. 2015 Jul 2;97(1):22-34.

81. Jiang L et al AR. Performance of case definitions for influenza surveillance. Euro Surveill. 2015 Jun 4; 20(22):21145

80. Michailidou K et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015 Apr;47(4):373-80.

79. Orr N et al. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum Mol Genet. 2015 May 15;24(10):2966-84.

78. Win AM et al. Patterns of physical activity and sedentary behavior in a representative sample of a multi-ethnic South-East Asian population: a cross-sectional study. BMC Public Health. 2015 Apr 1;15:318.

77. He M et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 Mar 15;24(6):1791-800.

76. Sabanayagam C et al. Diagnosis of Diabetes Mellitus Using HbA1c in Asians: Relationship Between HbA1c and Retinopathy in a Multiethnic Asian Population. J Clin Endocrinol Metab. 2015 Feb;100(2):689-96

75. Mahajan A et al. Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus. PLoS Genet. 2015 Jan 27;11(1):e1004876.

74. Lin WY et al. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet. 2015 Jan 1;24(1):285-98.

73. Hwang JY et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. Diabetes. 2015 Jan;64(1):291-8.

72. Glubb DM et al. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet. 2015 Jan 8;96(1):5-20.

2014

71. Qi Q et al. FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet. 2014 Dec 20;23(25):6961-72.

70. Brunham LR et al. Pharmacogenomic diversity in Singaporean populations and Europeans. Pharmacogenomics J. 2014 Dec;14(6):555-63.

69. Venkataraman K et al. Associations between disease awareness and health-related quality of life in a multi-ethnic Asian population. PLoS One. 2014 Nov 26;9(11):e113802

68. Sabanayagam C et al. Is chronic kidney disease associated with diabetic retinopathy in Asian adults? J Diabetes. 2014 Nov;6(6):556-63.

67. Milne RL et al. Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum Mol Genet. 2014 Nov 15;23(22):6096-111.

66. Wen W et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014 Oct 15;23(20):5492-504.

65. Ghoussaini M et al. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun. 2014 Sep 23;4:4999.

64. Pillai NE et al. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum Mol Genet. 2014 Aug 15;23(16):4443-51.

63. Cai Q et al. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nat Genet. 2014 Aug;46(8):886-90.

62. Hsu JP et al. Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore. BMC Infect Dis. 2014 Jul 28;14:414.

61. Chen P et al. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes. 2014 Jul;63(7):2551-62.

60. Phan TP et al. Forecasting the burden of type 2 diabetes in Singapore using a demographic epidemiological model of Singapore. BMJ Open Diabetes Res Care. 2014 Jun 11;2(1):e000012.

59. Wong LP et al. Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing. PLoS Genet. 2014 May 15;10(5):e1004377.

58. Johnson N et al. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study. Breast Cancer Res. 2014 May 26;16(3):R51.

57. Zuñiga YL et al. Rice and noodle consumption is associated with insulin resistance and hyperglycaemia in an Asian population. Br J Nutr. 2014 Mar 28;111(6):1118-28.

56. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44.

55. Wu Y et al. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Human molecular genetics. Hum Mol Genet. 2014 Feb 15;23(4):1108-19.

2013

54. Gao H et al. Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations. Diabetes. 2013 Dec;62(12):4277-83.

53. Kelly TN et al. Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension. 2013 Nov;62(5):853-9.

52. Chen P et al. A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. PLoS One. 2013 Nov 7;8(11):e79767.

51. Chen MI et al. Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore. Influenza Other Respir Viruses. 2013 Nov;7(6):1380-9.

50. Sng CC et al. Retinal vascular fractal and blood pressure in a multiethnic population. J Hypertens. 2013 Oct;31(10):2036-42.

49. Tan ML et al. The Short Form 36 English and Chinese versions were equivalent in a multiethnic Asian population. J Clin Epidemiol. 2013 Jul;66(7):759-67

48. Dorajoo R et al. Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? PLoS One. 2013 Jul 2;8(7):e67650.

47. Zheng W et al. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15;22(12):2539-50.

46. Venkataraman K et al. Associations between complications and health-related quality of life in individuals with diabetes. Clin Endocrinol (Oxf). 2013 Jun;78(6):865-73.

45. Ma RC et al. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia. 2013 Jun;56(6):1291-305.

44. Leow MK-S et al. Determinants of Health-Related Quality of Life (HRQoL) in the Multiethnic Singapore Population – A National Cohort Study. Schooling CM, ed. PLoS ONE. 2013;8(6):e67138.

43. Lam VK et al. Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One. 2013 Jun 11;8(6):e62378.

42. Nang EEK et al. Television screen time, but not computer use and reading time, is associated with cardio-metabolic biomarkers in a multiethnic Asian population: a cross-sectional study. The International Journal of Behavioral Nutrition and Physical Activity. 2013;10:70

41. Michailidou K et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2.

40. Garcia-Closas M et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr;45(4):392-8, 398e1-2.

39. French JD et al. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet. 2013 Apr 4;92(4):489-503.

38. Bojesen SE et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013 Apr;45(4):371-84, 384e1-2.

37. Wong LP et al. Deep whole-genome sequencing of 100 southeast Asian Malays. Am J Hum Genet. 2013 Jan 10;92(1):52-66. www.ncbi.nlm.nih.gov

2012

36. Lim XL et al. KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes. Diabetologia. 2012 Sep;55(9):2402-6.

35. Gao H et al. Can body fat distribution, adiponectin levels and inflammation explain differences in insulin resistance between ethnic Chinese, Malays and Asian Indians? Int J Obes (Lond). 2012 Aug;36(8):1086-93.

34. Venkataraman K et al. Ethnicity modifies the relation between fasting plasma glucose and HbA1c in Indians, Malays and Chinese. Diabet Med. 2012 Jul; 29(7): 911–917.

33. Okada Y et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet. 2012 Jul 15;44(8):904-9.

32. Lim XL et al. Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract. Diabetes Metab Syndr Obes. 2012;5:155-64.

31. Wang X et al. A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations. Eur J Hum Genet. 2012 Apr; 20(4): 469–475.

30. Wen W et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012 Feb 19;44(3):307-11.

29. Ng, D.P.K. et al. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia (2012) 55: 499.

28. Dorajoo R et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 2012 Jan;36(1):159-63.

2011

27. Fan Q et al. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genet. 2011 Dec;7(12):e1002402.

26. Cho YS et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67-72.

25. Nang EEK et al. Validity of the international physical activity questionnaire and the Singapore prospective study program physical activity questionnaire in a multiethnic urban Asian population. BMC Medical Research Methodology. 2011;11:141

24. International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9.

23. Han S et al. Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore. Hum Mol Genet. 2011 Sep 15;20(18):3693-8.

22. Ng DP et al. Nephrinuria associates with multiple renal traits in type 2 diabetes. Nephrol Dial Transplant. 2011 Aug;26(8):2508-14

21. Lim WY et al. Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009. Emerg Infect Dis. 2011 Aug;17(8):1455-62.

20. Anuradha S et al. Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic Asian population. Invest Ophthalmol Vis Sci. 2011 Aug 17;52(9):6522-8.

19. Rebello SA et al. Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study. Nutr J. 2011; 10: 61.

18. Sim X et al. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet. 2011 Apr;7(4):e1001363.

17. Kato N et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011 Jun;43(6):531-8.

16. Subramaniam T et al. Distribution of ankle–brachial index and the risk factors of peripheral artery disease in a multi-ethnic Asian population. Vasc Med. 2011 Apr;16(2):87-95.

15. Li YJ et al. Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. Ophthalmology. 2011 Feb;118(2):368-75.

2010

14. Khaing Nang EE et al. Patterns of physical activity in different domains and implications for intervention in a multi-ethnic Asian population: a cross-sectional study. BMC Public Health. 2010;10:644.

13. Shu XO et al. Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010 Sep 16;6(9):e1001127.

12. Teslovich TM et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 5;466(7307):707-13.

11. Sabanayagam C et al. C-reactive protein and microalbuminuria in a multi-ethnic Asian population. Nephrol Dial Transplant. 2010 Apr;25(4):1167-72.

10. Chen MI et al. 2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. JAMA. 2010 Apr 14;303(14):1383-91.

9. Tan JT et al. Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab. 2010 Jan;95(1):390-7

2009

8. Teo YY et al. Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations. Genome Res. 2009 Nov;19(11):2154-62.

7. Lee J et al. Influence of pre-hypertension on all-cause and cardiovascular mortality: The Singapore Cardiovascular Cohort Study. Int J Cardiol. 2009 Jul 10;135(3):331-7

6. Nang EE et al. Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program. Am J Epidemiol. 2009 Jun 15;169(12):1454-62.

2008

5. Ng DP et al. Reduced GFR and albuminuria in Chinese type 2 diabetes mellitus patients are both independently associated with activation of the TNF-alpha system. Diabetologia. 2008 Dec;51(12):2318-24.

4. Unoki H et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008;40:1098-1102.

3. Lee J et al. The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study. Clin Endocrinol (Oxf). 2008 Aug;69(2):225-30

2007

2. Lee J et al. Should central obesity be an optional or essential component of the metabolic syndrome? Ischemic heart disease risk in the Singapore Cardiovascular Cohort Study. Diabetes Care. 2007 Feb;30(2):343-7.

2006

1. Yeo KK et al. Ethnicity modifies the association between diabetes mellitus and ischaemic heart disease in Chinese, Malays and Asian Indians living in Singapore. Diabetologia. 2006 Dec;49(12):2866–2873