Publications

Merchant R et al. Singapore Healthy Older People Everyday (HOPE) Study: Prevalence of Frailty and Associated Factors in Older Adults. J Am Med Dir Assoc. 2017 Jun 13

Spracklen CN et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017 May 1;26(9):1770-1784

Han MR et al. 1. Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians. Carcinogenesis. 2017 May 1;38(5):511-518

Li C et al. Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians. Circ Cardiovasc Genet. 2017 Apr;10(2):e001527.

Shimelis H et al. BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. 2017 Mar 10.

Springelkamp H et al. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum Mol Genet. 2017 Jan 10. pii: ddw399.

Tan A et al. Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population. Sleep Breath. 2017 Jan 7

Khoo NKH et al. Comparative seroepidemiology of genital human papillomavirus infections in the general population in Singapore. Public Health 2017;142: 1-3.

Wen W et al. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Res. 2016 Dec 8;18(1):124

Liu J et al. rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk. Sci Rep. 2016 Nov 15;6:36874

Tan A et al. Using Berlin Questionnaire to Predict Obstructive Sleep Apnea in the General Population. J Clin Sleep Med. 2016 Nov 14

Ghoussaini M et al. Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. Am J Hum Genet. 2016 Oct 6;99(4):903-911

Tan A et al. Predicting obstructive sleep apnea using the STOP-Bang questionnaire in the general population. Sleep Med. 2016 Oct; 27(10): 66-71

Sia CH et al. Awareness and knowledge of obstructive sleep apnea in the general population. Sleep Med. Aug 2017; 36:10-17

Shi J et al. 6. Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int J Cancer.2016 Sep15; 139(6):1303-17

Lawrenson K et al. 7. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Comm. 2016 Sep 7;7:12675

Darabi H et al. 8. Fine scale mapping of the 17q22 breast cancer locus using de nse SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). Sci Rep. 2016 Sep 7;6:32512

Wyszynski A et al. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet. 2016 Sep 1;25(17):3863-3876

Horne HN et al. Fine-mapping of the 1p11.2 breast cancer susceptibility locus. PLoS One. 2016 Aug 24;11(8):e0160316

Fuchsberger C. et al. The genetic architecture of type 2 diabetes. Nature. 2016 Jul 11

Venkataraman K et al. Determinants of individuals’ participation in integrated chronic disease screening in Singapore. J Epidemiol Community Health 2016;70:1242-1250

Zeng C et al. Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res. 2016 Jun 21;18(1):64

Whitton C et al. Evaluation of Equations for Predicting 24-Hour Urinary Sodium Excretion from Casual Urine Samples in Asian Adults. J Nutr. 2016 Jun 29. pii: jn232108.

Cima I et al. Tumor-derived circulating endothelial cell clusters in colorectal cancer. Sci Transl Med. 2016 Jun 29;8(345):345ra89.

Zhao Z et al. Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control. 2016 Apr 6.

Dunning AM et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016 Apr;48(4):374-86.

Tan A et al. Prevalence of Sleep-Disordered Breathing in a Multiethnic Asian Population in Singapore: a Community-Based Study. Respirology. 2016 Feb 29.

Easton DF et al. No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. J Med Genet. 2016 Feb 26. pii: jmedgenet-2015-103529.

Horikoshi M et al. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet. 2016 Feb 23. pii: ddw048.

Wen W et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20;6:17958

Begum H et al. Discovering and validating between-subject variations in plasma lipids in healthy subjects. Sci Rep. 2016 Jan 8;6:19139

Lim CC et al. Chronic kidney disease, cardiovascular disease and mortality: A prospective cohort study in a multi-ethnic Asian population. Eur J Prev Cardiol. 2015 Aug;22(8):1018-26.

He M et al. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 Mar 15;24(6):1791-800.

Hwang JY et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. Diabetes. 2015 Jan;64(1):291-8.

Mahajan A et al. Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus. PLoS Genet. 2015 Jan 27;11(1):e1004876.

Koh HW et al. The Pittsburgh Sleep Quality Index in a multi-ethnic Asian population contains a three-factor structure. Sleep Breath. 2015 Dec;19(4):1147-54

Kato N et al. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov;47(11):1282-93.

Tan NC et al. 5-Year longitudinal study of determinants of glycemic control for multi-ethnic Asian patients with type 2 diabetes mellitus managed in primary care. Diabetes Res Clin Pract. 2015 Nov;110(2):218-23

Guo X et al. Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1680-91.

Nang EEK et al. Association of Television Viewing Time with Body Composition and Calcified Subclinical Atherosclerosis in Singapore Chinese. Maeda N, ed. PLoS ONE. 2015;10(7):e0132161.

Darabi H et al. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. Am J Hum Genet. 2015 Jul 2;97(1):22-34.

Jiang L et al AR. Performance of case definitions for influenza surveillance. Euro Surveill. 2015 Jun 4; 20(22):21145

Orr N et al. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum Mol Genet. 2015 May 15;24(10):2966-84.

Win AM et al. Patterns of physical activity and sedentary behavior in a representative sample of a multi-ethnic South-East Asian population: a cross-sectional study. BMC Public Health. 2015 Apr 1;15:318.

Michailidou K et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015 Apr;47(4):373-80.

Glubb DM et al. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet. 2015 Jan 8;96(1):5-20.

Lin WY et al. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet. 2015 Jan 1;24(1):285-98.

Hsu JP et al. Insights into T-cell mediated immunity to influenza infection from a population-based cohort study.

Qi Q et al. FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet. 2014 Dec 20;23(25):6961-72.

Brunham LR et al. Pharmacogenomic diversity in Singaporean populations and Europeans. Pharmacogenomics J. 2014 Dec;14(6):555-63.

Venkataraman K et al. Associations between disease awareness and health-related quality of life in a multi-ethnic Asian population. PLoS One. 2014 Nov 26;9(11):e113802.

Sabanayagam C et al. Is chronic kidney disease associated with diabetic retinopathy in Asian adults? J Diabetes. 2014 Nov;6(6):556-63.

Milne RL et al. Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum Mol Genet. 2014 Nov 15;23(22):6096-111.

Wen W et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014 Oct 15;23(20):5492-504.

Ghoussaini M et al. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun. 2014 Sep 23;4:4999.

Pillai NE et al. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum Mol Genet. 2014 Aug 15;23(16):4443-51.

Cai Q et al. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nat Genet. 2014 Aug;46(8):886-90.

Chen P et al. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes. 2014 Jul;63(7):2551-62.

Hsu JP et al. Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore. BMC Infect Dis. 2014 Jul 28;14:414.

Phan TP et al. Forecasting the burden of type 2 diabetes in Singapore using a demographic epidemiological model of Singapore. BMJ Open Diabetes Res Care. 2014 Jun 11;2(1):e000012.

Wong LP et al. Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing. PLoS Genet. 2014 May 15;10(5):e1004377.

Johnson N et al. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study. Breast Cancer Res. 2014 May 26;16(3):R51.

Zuñiga YL et al. Rice and noodle consumption is associated with insulin resistance and hyperglycaemia in an Asian population. Br J Nutr. 2014 Mar 28;111(6):1118-28.

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44.

Wu Y et al. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Human molecular genetics. Hum Mol Genet. 2014 Feb 15;23(4):1108-19.

Gao H et al. Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations. Diabetes. 2013 Dec;62(12):4277-83.

Kelly TN et al. Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension. 2013 Nov;62(5):853-9.

Chen P et al. A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. PLoS One. 2013 Nov 7;8(11):e79767.

Chen MI et al. Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore. Influenza Other Respir Viruses. 2013 Nov;7(6):1380-9.

Sng CC et al. Retinal vascular fractal and blood pressure in a multiethnic population. J Hypertens. 2013 Oct;31(10):2036-42.

Nang EEK et al. Television screen time, but not computer use and reading time, is associated with cardio-metabolic biomarkers in a multiethnic Asian population: a cross-sectional study. The International Journal of Behavioral Nutrition and Physical Activity. 2013;10:70

Leow MK-S et al. Determinants of Health-Related Quality of Life (HRQoL) in the Multiethnic Singapore Population – A National Cohort Study. Schooling CM, ed. PLoS ONE. 2013;8(6):e67138.

Dorajoo R et al. Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? PLoS One. 2013 Jul 2;8(7):e67650.

Tan ML et al. The Short Form 36 English and Chinese versions were equivalent in a multiethnic Asian population. J Clin Epidemiol. 2013 Jul;66(7):759-67

Venkataraman K et al. Associations between complications and health-related quality of life in individuals with diabetes. Clin Endocrinol (Oxf). 2013 Jun;78(6):865-73.

Lam VK et al. Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One. 2013 Jun 11;8(6):e62378.

Ma RC et al. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia. 2013 Jun;56(6):1291-305.

Zheng W et al. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15;22(12):2539-50.

French JD et al. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet. 2013 Apr 4;92(4):489-503.

Garcia-Closas M et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr;45(4):392-8, 398e1-2.

Bojesen SE et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013 Apr;45(4):371-84, 384e1-2.

Michailidou K et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2.

Wong LP et al. Deep whole-genome sequencing of 100 southeast Asian Malays. Am J Hum Genet. 2013 Jan 10;92(1):52-66.

Lim XL et al. KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes. Diabetologia. 2012 Sep;55(9):2402-6.

Gao H et al. Can body fat distribution, adiponectin levels and inflammation explain differences in insulin resistance between ethnic Chinese, Malays and Asian Indians? Int J Obes (Lond). 2012 Aug;36(8):1086-93.

Okada Y et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet. 2012 Jul 15;44(8):904-9.

Ng, D.P.K. et al. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia (2012) 55: 499.

Wang X et al. A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations. Eur J Hum Genet. 2012 Apr; 20(4): 469–475.

Wen W et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012 Feb 19;44(3):307-11.

Dorajoo R et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 2012 Jan;36(1):159-63.

Cho YS et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67-72.

Fan Q et al. Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genet. 2011 Dec;7(12):e1002402.

Nang EEK et al. Validity of the international physical activity questionnaire and the Singapore prospective study program physical activity questionnaire in a multiethnic urban Asian population. BMC Medical Research Methodology. 2011;11:141

Rebello SA et al. Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study. Nutr J. 2011; 10: 61.

Han S et al. Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore. Hum Mol Genet. 2011 Sep 15;20(18):3693-8.

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9.

Anuradha S et al. Associations of physical activity and television viewing time with retinal vascular caliber in a multiethnic Asian population. Invest Ophthalmol Vis Sci. 2011 Aug 17;52(9):6522-8.

Ng DP et al. Nephrinuria associates with multiple renal traits in type 2 diabetes. Nephrol Dial Transplant. 2011 Aug;26(8):2508-14

Lim WY et al. Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009. Emerg Infect Dis. 2011 Aug;17(8):1455-62.

Kato N et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011 Jun;43(6):531-8.

Subramaniam T et al. Distribution of ankle–brachial index and the risk factors of peripheral artery disease in a multi-ethnic Asian population. Vasc Med. 2011 Apr;16(2):87-95.

Sim X et al. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet. 2011 Apr;7(4):e1001363.

Li YJ et al. Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. Ophthalmology. 2011 Feb;118(2):368-75.

Shu XO et al. Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010 Sep 16;6(9):e1001127.

Khaing Nang EE et al. Patterns of physical activity in different domains and implications for intervention in a multi-ethnic Asian population: a cross-sectional study. BMC Public Health. 2010;10:644.

Teslovich TM et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 5;466(7307):707-13.

Chen MI et al. 2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. JAMA. 2010 Apr 14;303(14):1383-91.

Sabanayagam C et al. C-reactive protein and microalbuminuria in a multi-ethnic Asian population. Nephrol Dial Transplant. 2010 Apr;25(4):1167-72.

Tan JT et al. Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab. 2010 Jan;95(1):390-7

Teo YY et al. Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations. Genome Res. 2009 Nov;19(11):2154-62.

Lee J et al. Influence of pre-hypertension on all-cause and cardiovascular mortality: The Singapore Cardiovascular Cohort Study. Int J Cardiol. 2009 Jul 10;135(3):331-7

Nang EE et al. Is there a clear threshold for fasting plasma glucose that differentiates between those with and without neuropathy and chronic kidney disease?: the Singapore Prospective Study Program. Am J Epidemiol. 2009 Jun 15;169(12):1454-62.

Ng DP et al. Reduced GFR and albuminuria in Chinese type 2 diabetes mellitus patients are both independently associated with activation of the TNF-alpha system. Diabetologia. 2008 Dec;51(12):2318-24.

Lee J et al. The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study. Clin Endocrinol (Oxf). 2008 Aug;69(2):225-30

Unoki H et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008;40:1098-1102.

Lee J et al. Should central obesity be an optional or essential component of the metabolic syndrome? Ischemic heart disease risk in the Singapore Cardiovascular Cohort Study. Diabetes Care. 2007 Feb;30(2):343-7.

Yeo KK et al. Ethnicity modifies the association between diabetes mellitus and ischaemic heart disease in Chinese, Malays and Asian Indians living in Singapore. Diabetologia (2006) 49:2866–2873

Last updated on 31 July 2017