Quantitative Approaches in Medicine

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About

Name: TAN Chuen Seng
Contact Information

Email:
ephtcs@nus.edu.sg

Address:
Saw Swee Hock School of Public Health
National University of Singapore
MD3, 16 Medical Drive
Singapore 117597

Telephone:
65-6516 6357

Fax:
65-6779 1489

Research Objectives

  • To conduct inter-disciplinary research, integrating knowledge across Biostatistics, Epidemiology and Medicine, and improving human health
  • To conduct data-centric research, translating data into knowledge and understanding the world around us

Research Interests

  • Biostatistics
  • Clinical Genomics
  • Epidemiology

Education

Ph.D. in Medical Science under the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden, 2008
Thesis: Statistical methods for biomarker discovery in proteomics.

M.Sc. by Research under the Department of Statistics and Applied Probability, National University of Singapore, Singapore, 2002
Thesis: Modeling buying behavior.

B.Sc. with Honors in Mathematics, Science Faculty, National University of Singapore, Singapore, 2001

B.Sc. with Merit in Economics and Mathematics, Science Faculty, National University of Singapore, Singapore, 2000

Experience

  • Research Fellow at the Saw Swee Hock School of Public Health, National University of Singapore (Aug 2011 – present)
  • Postdoctoral Research Associate and Co-Instructor at the John Storey Laboratory, Lewis-Sigler Institute for Integrative Genomics, Princeton University (Nov 2008 – Aug 2011)
  • Research Assistant at the Center for Molecular Epidemiology, National University of Singapore-Genome Institute of Singapore (Sept 2002 – Oct 2008)

Scholarships, Awards and Travel Grants

  • Awarded Karolinska Institutet travel grant for a poster presentation at “Conference on Design and Analysis Issues in Genomic Studies in Population Sciences,” October 11-12, 2007, Boston, USA.
  • Awarded travel grant from the organizers of “Statistics for Biomolecular Data Integration and Modeling Workshop,” June 10-15, 2007 in Ascona, Switzerland.
  • Awarded National University of Singapore Research Scholarship in 2001/2002 when pursing the Masters of Science under the Accelerated Masters Programme by Research.
  • Awarded National University of Singapore, Science Faculty Dean’s List in 1997/98 Semester I and 1998/99 Semester II.

Publications

Methods:

  • Tan CS*, Desai KH*, Leek JT, Maier RW, Tompkins RG, Storey JD, and the Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program. “Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.” PLoS Med 2011, 8:e1001093. *Equal contributors
  • Tan CS, Salim A, Ploner A, Lehtiö J, Chia KS, Pawitan Y. “Correlating gene and protein expression data using Correlated Factor Analysis.” BMC Bioinformatics 2009, 10:272.
  • Forshed J, Pernemalm M, Tan CS, Lindberg M, Kanter L, Pawitan Y, Lewensohn R, Stenke L, Lehtiö J. “Proteomic data analysis workflow for discovery of candidate biomarker peaks predictive of clinical outcome for patients with acute myeloid leukemia.” J Proteome Res. 2008; 7(6):2332-41.
  • Tan CS, Ploner A, Quandt A, Lehtiö J,  Pernemalm M, Lewensohn R, Pawitan Y. “Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biomarkers.” Proteomics. 2006 Dec; 6(23):6124-33.
  • Tan CS, Ploner A, Quandt A, Lehtiö J, Pawitan Y. “Finding regions of significance in SELDI measurements for identifying protein biomarkers.” Bioinformatics. 2006 Jun; 22(12):1515–23.
  • Quandt A, Ploner A, Tan CS, Lehtiö J, Pawitan Y. “ProSpect: An R Package for Analyzing SELDI Measurements Identifying Protein Biomarkers.” Lecture Notes in Computer Science. 2005 Sep; 3695:140-150.

Applications:

  • Chia SE, Tan CS, Lim GH, Sim XL, Safiyya MA, Lau W, Chia KS. “Incidence, Mortality and 5-year Relative Survival Rate of Prostate Cancer among Chinese Residents in Singapore from 1968 to 2002 by Metastatic Staging.”  Ann Acad Med Singapore. 2010; 39:466-71.
  • Lee J, Tan CS, Chia KS. “A Practical Guide for Multivariate Analysis of Dichotomous Outcomes.” Ann Acad Med Singapore. 2009; 38:714-9.
  • Tan MH, Tan CS, Lim WY. “Race to report: are vascular endothelial growth factor genetic polymorphisms associated with outcome in advanced breast cancer patients treated with Paclitaxel plus bevacizumab?” J Clin Oncol. 2008 Oct 1; 26(28):4672-8.
  • Chia SE, Tan CS, Lim GH, Sim X, Pawitan Y, Reilly M, Mohamed Ali S, Lau W, Chia KS. “Incidence, Mortality Patterns and 5-year Relative Survival Ratio of Prostate Cancer among Residents in Singapore from 1968 to 2002.” BMC Cancer. 2008; 8(1):368.
  • de Kok IM, Wong CS, Chia KS, Sim X, Tan CS, Kiemeney LA, Verkooijen HM. “Gender differences in the trend of colorectal cancer incidence in Singapore, 1968-2002.” Int J Colorectal Dis. 2008; 23(5):461-7.
  • Luo J, Chia KS, Chia SE, Reilly M, Tan CS, Ye W. “Secular trends of nasopharyngeal carcinoma incidence in Singapore, Hong Kong and Los Angeles Chinese populations, 1973-1997.” Eur J Epidemiol. 2007; 22(8):513-21.
  • Mok BW, Ribacke U, Winter G, Yip BH, Tan CS, Fernandez V, Chen Q, Nilsson P, Wahlgren M, “Comparative transcriptomal analysis of isogenic Plasmodium falciparum clones of distinct antigenic and adhesive phenotypes.” Mol Biochem Parasitol. 2007; 151(2):184-92.
  • Sim X, Ali RA, Wedren S, Goh DLG, Tan CS, Reilly M, Hall P and Chia KS. “Ethnic Differences in the Time Trend of Female Breast Cancer Incidence: Singapore, 1968-2002.” BMC Cancer. 2006; 6:261.
  • Chan E, Tan CS, Deurenberg-Yap M, Chia KS, Chew SK, Tai ES. “The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women.” Atherosclerosis. 2006 Aug; 187(2), 309-15.
  • Chia KS, Reilly M, Tan CS, Mow B, Lee J, Pawitan Y, Adami HO, Hall P. “Profound changes in breast cancer incidence may reflect changes into a westernised lifestyle: a comparative population-based study in Singapore and Sweden.” Int J Cancer. 2005; 113(2):302-6.
  • Lee J, Tan CS, Chia KS, Tan CE, Chew SK, Ordovas JM, Tai ES. “The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption.” J Lipid Res. 2004; 45(6):1132-9.
  • Tan CE, Tai ES, Tan CS, Chia KS, Lee J, Chew SK, Ordovas JM. “APOE polymorphism and lipid profile in three ethnic groups in the Singapore population.” Atherosclerosis. 2003; 170(2):253-60.